PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
16455059-2	2006	CYP19/aromatase is the major placental enzyme responsible for the metabolism of methadone to 2-ethylidine-1,5-dimethyl-3,3-diphenylpyrrolidine (EDDP) and BUP to norbuprenorphine (norBUP).	2-ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidine	144-148	cytochrome P450 family 19 subfamily A member 1	Homo sapiens	0-5	
15242824-7	2004	Aminoglutethimide and 4-hydroxyandrostenedione inhibited EDDP formation by 88 and 70%, respectively, suggesting that CYP19/aromatase is the enzyme catalyzing the reaction.	2-ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidine	57-61	cytochrome P450 family 19 subfamily A member 1	Homo sapiens	117-122	
15242824-9	2004	The apparent K(m) and V(max) values for the CYP19 catalyzed metabolism of methadone to EDDP were 424 +/- 92 microM and 420 +/- 89 pmol(mgprotein)(-1)min(-1), respectively.	2-ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidine	87-91	cytochrome P450 family 19 subfamily A member 1	Homo sapiens	44-49	
15242824-10	2004	Kinetic analysis of a cDNA-expressed CYP19 for the metabolism of methadone to EDDP was identical to that by placental microsomes.	2-ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidine	78-82	cytochrome P450 family 19 subfamily A member 1	Homo sapiens	37-42	
15242824-11	2004	Taken together, these data indicate that CYP19/aromatase is the major enzyme responsible for the metabolism of methadone to EDDP in term human placentas obtained from healthy pregnancies.	2-ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidine	124-128	cytochrome P450 family 19 subfamily A member 1	Homo sapiens	41-46	
20410453-7	2010	Preincubation of methadone, EDDP, or EMDP with CYP19 resulted in time- and concentration-dependent inhibition, indicating a mechanism-based reaction that destroys CYP19 activity.	2-ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidine	28-32	cytochrome P450 family 19 subfamily A member 1	Homo sapiens	47-52	
20410453-7	2010	Preincubation of methadone, EDDP, or EMDP with CYP19 resulted in time- and concentration-dependent inhibition, indicating a mechanism-based reaction that destroys CYP19 activity.	2-ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidine	28-32	cytochrome P450 family 19 subfamily A member 1	Homo sapiens	163-168