PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 31283708-2 2019 Tryptophan hydroxylase-2 (TPH2) is the rate-limiting enzyme of central serotonin (5-hydroxytryptamine) synthesis which converts l-tryptophan to 5-hydroxytryptophan. 5-Hydroxytryptophan 144-163 tryptophan hydroxylase 2 Mus musculus 0-24 31283708-2 2019 Tryptophan hydroxylase-2 (TPH2) is the rate-limiting enzyme of central serotonin (5-hydroxytryptamine) synthesis which converts l-tryptophan to 5-hydroxytryptophan. 5-Hydroxytryptophan 144-163 tryptophan hydroxylase 2 Mus musculus 26-30 27302625-3 2016 The tryptophan hydroxylase-2 (TPH2) enzyme converts L-tryptophan to 5-hydroxytryptophan (5-HTP), a precursor for central nervous system (CNS) serotonin (5-HT) synthesis; and DBA/1 mice have a polymorphism that decreases TPH2 activity. 5-Hydroxytryptophan 68-87 tryptophan hydroxylase 2 Mus musculus 4-28 29935278-6 2019 Tryptophan hydroxylase 2 (TPH2) activity was measured following injection of the aromatic amino acid decarboxylase (AADC)-inhibitor, NSD-1015, and subsequent HPLC detection of 5-hydroxytryptophan (5-HTP) within subregions of the dorsal raphe nucleus (DR) and median raphe nucleus (MnR). 5-Hydroxytryptophan 176-195 tryptophan hydroxylase 2 Mus musculus 0-24 29935278-6 2019 Tryptophan hydroxylase 2 (TPH2) activity was measured following injection of the aromatic amino acid decarboxylase (AADC)-inhibitor, NSD-1015, and subsequent HPLC detection of 5-hydroxytryptophan (5-HTP) within subregions of the dorsal raphe nucleus (DR) and median raphe nucleus (MnR). 5-Hydroxytryptophan 176-195 tryptophan hydroxylase 2 Mus musculus 26-30 29935278-6 2019 Tryptophan hydroxylase 2 (TPH2) activity was measured following injection of the aromatic amino acid decarboxylase (AADC)-inhibitor, NSD-1015, and subsequent HPLC detection of 5-hydroxytryptophan (5-HTP) within subregions of the dorsal raphe nucleus (DR) and median raphe nucleus (MnR). 5-Hydroxytryptophan 197-202 tryptophan hydroxylase 2 Mus musculus 0-24 29935278-6 2019 Tryptophan hydroxylase 2 (TPH2) activity was measured following injection of the aromatic amino acid decarboxylase (AADC)-inhibitor, NSD-1015, and subsequent HPLC detection of 5-hydroxytryptophan (5-HTP) within subregions of the dorsal raphe nucleus (DR) and median raphe nucleus (MnR). 5-Hydroxytryptophan 197-202 tryptophan hydroxylase 2 Mus musculus 26-30 27302625-3 2016 The tryptophan hydroxylase-2 (TPH2) enzyme converts L-tryptophan to 5-hydroxytryptophan (5-HTP), a precursor for central nervous system (CNS) serotonin (5-HT) synthesis; and DBA/1 mice have a polymorphism that decreases TPH2 activity. 5-Hydroxytryptophan 68-87 tryptophan hydroxylase 2 Mus musculus 30-34 27302625-3 2016 The tryptophan hydroxylase-2 (TPH2) enzyme converts L-tryptophan to 5-hydroxytryptophan (5-HTP), a precursor for central nervous system (CNS) serotonin (5-HT) synthesis; and DBA/1 mice have a polymorphism that decreases TPH2 activity. 5-Hydroxytryptophan 68-87 tryptophan hydroxylase 2 Mus musculus 220-224 27302625-3 2016 The tryptophan hydroxylase-2 (TPH2) enzyme converts L-tryptophan to 5-hydroxytryptophan (5-HTP), a precursor for central nervous system (CNS) serotonin (5-HT) synthesis; and DBA/1 mice have a polymorphism that decreases TPH2 activity. 5-Hydroxytryptophan 89-94 tryptophan hydroxylase 2 Mus musculus 4-28 27302625-3 2016 The tryptophan hydroxylase-2 (TPH2) enzyme converts L-tryptophan to 5-hydroxytryptophan (5-HTP), a precursor for central nervous system (CNS) serotonin (5-HT) synthesis; and DBA/1 mice have a polymorphism that decreases TPH2 activity. 5-Hydroxytryptophan 89-94 tryptophan hydroxylase 2 Mus musculus 30-34 27302625-3 2016 The tryptophan hydroxylase-2 (TPH2) enzyme converts L-tryptophan to 5-hydroxytryptophan (5-HTP), a precursor for central nervous system (CNS) serotonin (5-HT) synthesis; and DBA/1 mice have a polymorphism that decreases TPH2 activity. 5-Hydroxytryptophan 89-94 tryptophan hydroxylase 2 Mus musculus 220-224 23935583-7 2013 When the Tph2-dependent 5-HT synthesis step was bypassed by application of 5-hydroxy-L-tryptophan (5-HTP), neurons from both Tph2-/- and Sert-/- mice decreased their firing rates at significantly lower concentrations of 5-HTP compared to wildtype controls. 5-Hydroxytryptophan 75-97 tryptophan hydroxylase 2 Mus musculus 9-13 26259827-5 2015 The role of endogenous 5-HT in enhancing the effect of amphetamine was confirmed showing that treatment with the 5-HT precursor 5-hydroxytryptophan (10 mg/kg) restored tissue and extracellular levels of brain 5-HT and the effects of amphetamine on striatal NA release and motor activity in Tph2(-/-) mice. 5-Hydroxytryptophan 128-147 tryptophan hydroxylase 2 Mus musculus 290-294 23935583-7 2013 When the Tph2-dependent 5-HT synthesis step was bypassed by application of 5-hydroxy-L-tryptophan (5-HTP), neurons from both Tph2-/- and Sert-/- mice decreased their firing rates at significantly lower concentrations of 5-HTP compared to wildtype controls. 5-Hydroxytryptophan 75-97 tryptophan hydroxylase 2 Mus musculus 125-129 23935583-7 2013 When the Tph2-dependent 5-HT synthesis step was bypassed by application of 5-hydroxy-L-tryptophan (5-HTP), neurons from both Tph2-/- and Sert-/- mice decreased their firing rates at significantly lower concentrations of 5-HTP compared to wildtype controls. 5-Hydroxytryptophan 99-104 tryptophan hydroxylase 2 Mus musculus 9-13 23935583-7 2013 When the Tph2-dependent 5-HT synthesis step was bypassed by application of 5-hydroxy-L-tryptophan (5-HTP), neurons from both Tph2-/- and Sert-/- mice decreased their firing rates at significantly lower concentrations of 5-HTP compared to wildtype controls. 5-Hydroxytryptophan 99-104 tryptophan hydroxylase 2 Mus musculus 125-129 23935583-7 2013 When the Tph2-dependent 5-HT synthesis step was bypassed by application of 5-hydroxy-L-tryptophan (5-HTP), neurons from both Tph2-/- and Sert-/- mice decreased their firing rates at significantly lower concentrations of 5-HTP compared to wildtype controls. 5-Hydroxytryptophan 220-225 tryptophan hydroxylase 2 Mus musculus 9-13 23935583-7 2013 When the Tph2-dependent 5-HT synthesis step was bypassed by application of 5-hydroxy-L-tryptophan (5-HTP), neurons from both Tph2-/- and Sert-/- mice decreased their firing rates at significantly lower concentrations of 5-HTP compared to wildtype controls. 5-Hydroxytryptophan 220-225 tryptophan hydroxylase 2 Mus musculus 125-129 22443164-7 2012 Restoration of 5HT levels by treatment of Tph2-/- mice with its immediate precursor 5-hydroxytryptophan attenuated compulsive and impulsive-aggressive behaviors. 5-Hydroxytryptophan 84-103 tryptophan hydroxylase 2 Mus musculus 42-46 23558391-8 2013 Whereas 1-2 h of 5-HTP treatment improved the gasp latency and fB of P8-9 TPH2(-/-) pups, improved cardiorespiratory recovery and survival required 24 h of treatment. 5-Hydroxytryptophan 17-22 tryptophan hydroxylase 2 Mus musculus 74-78 21441904-5 2011 Thirty-five minutes after the injection of the intermediate 5-hydroxytryptophan (5-HTP), which circumvented Tph2 to restore 5-HT to the wild-type level, adult Tph2 knockout mice also preferred females over males. 5-Hydroxytryptophan 60-79 tryptophan hydroxylase 2 Mus musculus 108-112 21441904-5 2011 Thirty-five minutes after the injection of the intermediate 5-hydroxytryptophan (5-HTP), which circumvented Tph2 to restore 5-HT to the wild-type level, adult Tph2 knockout mice also preferred females over males. 5-Hydroxytryptophan 60-79 tryptophan hydroxylase 2 Mus musculus 159-163 21441904-5 2011 Thirty-five minutes after the injection of the intermediate 5-hydroxytryptophan (5-HTP), which circumvented Tph2 to restore 5-HT to the wild-type level, adult Tph2 knockout mice also preferred females over males. 5-Hydroxytryptophan 81-86 tryptophan hydroxylase 2 Mus musculus 108-112 21441904-5 2011 Thirty-five minutes after the injection of the intermediate 5-hydroxytryptophan (5-HTP), which circumvented Tph2 to restore 5-HT to the wild-type level, adult Tph2 knockout mice also preferred females over males. 5-Hydroxytryptophan 81-86 tryptophan hydroxylase 2 Mus musculus 159-163 17492791-1 2007 The recent discovery of TPH-2, a new isoform of tryptophan hydroxylase, the enzyme that catalyses the transformation of tryptophan into 5-hydroxytryptophan and the rate-limiting step in brain serotonin (5-HT) biosynthesis, has boosted new interest in the many functions of 5-HT in the brain and non-nervous tissues. 5-Hydroxytryptophan 136-155 tryptophan hydroxylase 2 Mus musculus 24-29