PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 20022592-0 2010 A novel role for glyceraldehyde-3-phosphate dehydrogenase and monoamine oxidase B cascade in ethanol-induced cellular damage. Ethanol 93-100 monoamine oxidase B Homo sapiens 62-81 22890201-6 2012 Furthermore, KLF11 may influence MAO-B expression and augment glyceraldehyde-3 phosphate dehydrogenase (GAPDH) to upregulate MAO-B transcription upon exposure to ethanol. Ethanol 162-169 monoamine oxidase B Homo sapiens 125-130 20022592-11 2010 CONCLUSIONS: Ethanol-elicited nuclear GAPDH augments TIEG2-mediated MAO B, which might play a role in brain damage in subjects with alcoholism. Ethanol 13-20 monoamine oxidase B Homo sapiens 68-73 32753686-4 2021 Ethanol treatment resulted in decreased 5-HT concentrations in human induced pluripotent stem cell (iPSC)-derived neuron culture media, and the downregulation of gene expression of TSPAN5, DDC, MAOA, MAOB, TPH1, and TPH2 in those cells. Ethanol 0-7 monoamine oxidase B Homo sapiens 200-204 20022592-3 2010 Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) and monoamine oxidase B (MAO B) reportedly play a role in cellular dysfunction under stressful conditions and might contribute to EtOH-induced cell damage. Ethanol 179-183 monoamine oxidase B Homo sapiens 53-72 20022592-3 2010 Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) and monoamine oxidase B (MAO B) reportedly play a role in cellular dysfunction under stressful conditions and might contribute to EtOH-induced cell damage. Ethanol 179-183 monoamine oxidase B Homo sapiens 74-79 20022592-4 2010 METHODS: Expression of GAPDH and MAO B protein was studied in human glioblastoma and neuroblastoma cell lines exposed to physiological concentrations of EtOH. Ethanol 153-157 monoamine oxidase B Homo sapiens 33-38 20022592-8 2010 RESULTS: Ethanol significantly increases levels of GAPDH, especially nuclear GAPDH, and MAO B in neuronal cells as well as in human and rat brains. Ethanol 9-16 monoamine oxidase B Homo sapiens 88-93 20022592-9 2010 Nuclear GAPDH interacts with the transcriptional activator, transforming growth factor-beta-inducible early gene 2 (TIEG2), and augments TIEG2-mediated MAO B transactivation, which results in cell damage in neuronal cells exposed to EtOH. Ethanol 233-237 monoamine oxidase B Homo sapiens 152-157 19946577-3 2008 We previously reported that ethanol exposure lowered cell proliferation and increased cell apoptosis in all cell types, but affects brain cell lines the most, while ethanol and the anti-depressant drug deprenyl, an monoamine oxidase B (MAO B) inhibitor, exposure in unison increases cell viability. Ethanol 28-35 monoamine oxidase B Homo sapiens 215-234 19526291-0 2009 Glyceraldehyde-3-phosphate dehydrogenase-monoamine oxidase B-mediated cell death-induced by ethanol is prevented by rasagiline and 1-R-aminoindan. Ethanol 92-99 monoamine oxidase B Homo sapiens 41-60 19526291-3 2009 Here, we provide evidence that GAPDH potentiates the ethanol-induced activity of MAO B and brain cell toxicity. Ethanol 53-60 monoamine oxidase B Homo sapiens 81-86 19526291-4 2009 The levels of nuclear GAPDH and MAO B activity are significantly increased in brain-derived cell lines upon 75 mM ethanol-induced cell death. Ethanol 114-121 monoamine oxidase B Homo sapiens 32-37 19526291-5 2009 Over-expression of GAPDH in cells enhances ethanol-induced cell death, and also increases the ethanol-induced activation of MAO B. Ethanol 94-101 monoamine oxidase B Homo sapiens 124-129 19526291-6 2009 In contrast, the MAO B inhibitors rasagiline and selegiline (0.25 nM) and the rasagiline metabolite, 1-R-aminoindan (1 muM) decreases the ethanol-induced MAO B, prevents nuclear translocation of GAPDH and reduces cell death. Ethanol 138-145 monoamine oxidase B Homo sapiens 17-22 19526291-6 2009 In contrast, the MAO B inhibitors rasagiline and selegiline (0.25 nM) and the rasagiline metabolite, 1-R-aminoindan (1 muM) decreases the ethanol-induced MAO B, prevents nuclear translocation of GAPDH and reduces cell death. Ethanol 138-145 monoamine oxidase B Homo sapiens 154-159 19526291-9 2009 In summary, ethanol-induced cell death, attenuated by MAO B inhibitors, may result from disrupting the movement of GAPDH with the transcriptional activator into the nucleus and secondly inhibit MAO B gene expression. Ethanol 12-19 monoamine oxidase B Homo sapiens 54-59 19526291-9 2009 In summary, ethanol-induced cell death, attenuated by MAO B inhibitors, may result from disrupting the movement of GAPDH with the transcriptional activator into the nucleus and secondly inhibit MAO B gene expression. Ethanol 12-19 monoamine oxidase B Homo sapiens 194-199 19526291-10 2009 Thus, the neuroprotective effects of rasagiline or 1-R-aminoindan on ethanol-induced cell death mediated by a novel GAPDH-MAO B pathway may provide a new insight in the treatment of neurobiological diseases including alcohol-use disorders. Ethanol 69-76 monoamine oxidase B Homo sapiens 122-127 19946577-3 2008 We previously reported that ethanol exposure lowered cell proliferation and increased cell apoptosis in all cell types, but affects brain cell lines the most, while ethanol and the anti-depressant drug deprenyl, an monoamine oxidase B (MAO B) inhibitor, exposure in unison increases cell viability. Ethanol 28-35 monoamine oxidase B Homo sapiens 236-241 19946577-8 2008 We have found that ethanol exposure increases the levels of mRNA and protein/catalytic activity for both TIEG2 and MAO B, while ethanol and deprenyl exposure in unison reduce the expression of both TIEG2 and MAO B, however it increases cell viability. Ethanol 19-26 monoamine oxidase B Homo sapiens 115-120 19946577-8 2008 We have found that ethanol exposure increases the levels of mRNA and protein/catalytic activity for both TIEG2 and MAO B, while ethanol and deprenyl exposure in unison reduce the expression of both TIEG2 and MAO B, however it increases cell viability. Ethanol 19-26 monoamine oxidase B Homo sapiens 208-213 19946577-8 2008 We have found that ethanol exposure increases the levels of mRNA and protein/catalytic activity for both TIEG2 and MAO B, while ethanol and deprenyl exposure in unison reduce the expression of both TIEG2 and MAO B, however it increases cell viability. Ethanol 128-135 monoamine oxidase B Homo sapiens 208-213 8836930-5 1996 In contrast, increases (2-3-fold) in both reporter gene expression and enzyme activity were observed after ethanol treatment of cells transfected with MAO-B fragments. Ethanol 107-114 monoamine oxidase B Homo sapiens 151-156 11022024-2 2000 In the present study, the relationship between these two markers was investigated in a group of socially stable Caucasian middle-aged men with a mean (+/-SD) daily ethanol consumption of 85 +/- 57 g. The platelet MAO-B activity was significantly lower in individuals with the DRD2 A1 allele (n = 8), compared to those without it (n = 29). Ethanol 164-171 monoamine oxidase B Homo sapiens 213-218 10761214-0 1999 [Ethanol inhibits platelet monoamine oxidase type B activity in patients with alcoholism]. Ethanol 1-8 monoamine oxidase B Homo sapiens 27-51 10761214-1 1999 The influence of 400 mM ethanol on the activity of monoamine oxidase type B (MAO-B) of blood platelets has been studied in vitro in 30 alcoholic patients and 30 healthy volunteers. Ethanol 24-31 monoamine oxidase B Homo sapiens 51-75 10761214-1 1999 The influence of 400 mM ethanol on the activity of monoamine oxidase type B (MAO-B) of blood platelets has been studied in vitro in 30 alcoholic patients and 30 healthy volunteers. Ethanol 24-31 monoamine oxidase B Homo sapiens 77-82 10761214-3 1999 MAO-B inhibition by ethanol was higher in alcoholics compared to healthy volunteers. Ethanol 20-27 monoamine oxidase B Homo sapiens 0-5 10761214-4 1999 The higher vulnerability of MAO-B of alcoholics inhibiting action to of ethanol may be one of the mechanisms underlying some symptoms of alcoholism. Ethanol 72-79 monoamine oxidase B Homo sapiens 28-33 8836930-6 1996 Gel retardation analysis showed that ethanol caused changes in transcription factor binding to the MAO-B core promoter in both the SH-SY5Y and 1242 MG cell lines in a cell-type specific fashion. Ethanol 37-44 monoamine oxidase B Homo sapiens 99-104 7931267-2 1994 Ethanol (ETOH) in vitro displays a competitive inhibition of human platelet MAO-B with a Ki of 270 +/- 30 mM. Ethanol 0-7 monoamine oxidase B Homo sapiens 76-81 7931267-2 1994 Ethanol (ETOH) in vitro displays a competitive inhibition of human platelet MAO-B with a Ki of 270 +/- 30 mM. Ethanol 9-13 monoamine oxidase B Homo sapiens 76-81