PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 7476899-7 1995 Consistent with this hypothesis, ethanol significantly reduced glycine affinity at NR1/NR2A and NR1/NR2C receptors. Ethanol 33-40 glutamate ionotropic receptor NMDA type subunit 1 L homeolog Xenopus laevis 83-86 7476899-1 1995 Ethanol inhibits N-methyl-D-aspartate (NMDA) receptor-mediated responses at pharmacologically relevant concentrations, suggesting that inhibition of NMDA receptors may underlie some of the actions of ethanol in the central nervous system. Ethanol 0-7 glutamate ionotropic receptor NMDA type subunit 1 L homeolog Xenopus laevis 17-53 7476899-1 1995 Ethanol inhibits N-methyl-D-aspartate (NMDA) receptor-mediated responses at pharmacologically relevant concentrations, suggesting that inhibition of NMDA receptors may underlie some of the actions of ethanol in the central nervous system. Ethanol 200-207 glutamate ionotropic receptor NMDA type subunit 1 L homeolog Xenopus laevis 17-53 7476899-7 1995 Consistent with this hypothesis, ethanol significantly reduced glycine affinity at NR1/NR2A and NR1/NR2C receptors. Ethanol 33-40 glutamate ionotropic receptor NMDA type subunit 1 L homeolog Xenopus laevis 96-99 7476899-3 1995 Ethanol dose-response analysis revealed enhanced inhibitory efficacy of ethanol in the presence of subsaturating glycine concentrations at the NR1/NR2A, NR1/NR2C, and NR1/NR2D receptors. Ethanol 0-7 glutamate ionotropic receptor NMDA type subunit 1 L homeolog Xenopus laevis 143-146 7476899-3 1995 Ethanol dose-response analysis revealed enhanced inhibitory efficacy of ethanol in the presence of subsaturating glycine concentrations at the NR1/NR2A, NR1/NR2C, and NR1/NR2D receptors. Ethanol 0-7 glutamate ionotropic receptor NMDA type subunit 1 L homeolog Xenopus laevis 153-156 7476899-8 1995 Evaluation of the glycine-independent component of ethanol inhibition demonstrated that in the presence of saturating concentrations of glycine, the NR1/NR2A and NR1/NR2B receptors were more sensitive to ethanol than the NR1/NR2C and NR1/NR2D receptors. Ethanol 51-58 glutamate ionotropic receptor NMDA type subunit 1 L homeolog Xenopus laevis 149-152 7476899-3 1995 Ethanol dose-response analysis revealed enhanced inhibitory efficacy of ethanol in the presence of subsaturating glycine concentrations at the NR1/NR2A, NR1/NR2C, and NR1/NR2D receptors. Ethanol 0-7 glutamate ionotropic receptor NMDA type subunit 1 L homeolog Xenopus laevis 153-156 7476899-3 1995 Ethanol dose-response analysis revealed enhanced inhibitory efficacy of ethanol in the presence of subsaturating glycine concentrations at the NR1/NR2A, NR1/NR2C, and NR1/NR2D receptors. Ethanol 72-79 glutamate ionotropic receptor NMDA type subunit 1 L homeolog Xenopus laevis 143-146 7476899-3 1995 Ethanol dose-response analysis revealed enhanced inhibitory efficacy of ethanol in the presence of subsaturating glycine concentrations at the NR1/NR2A, NR1/NR2C, and NR1/NR2D receptors. Ethanol 72-79 glutamate ionotropic receptor NMDA type subunit 1 L homeolog Xenopus laevis 153-156 7476899-8 1995 Evaluation of the glycine-independent component of ethanol inhibition demonstrated that in the presence of saturating concentrations of glycine, the NR1/NR2A and NR1/NR2B receptors were more sensitive to ethanol than the NR1/NR2C and NR1/NR2D receptors. Ethanol 51-58 glutamate ionotropic receptor NMDA type subunit 1 L homeolog Xenopus laevis 162-165 7476899-3 1995 Ethanol dose-response analysis revealed enhanced inhibitory efficacy of ethanol in the presence of subsaturating glycine concentrations at the NR1/NR2A, NR1/NR2C, and NR1/NR2D receptors. Ethanol 72-79 glutamate ionotropic receptor NMDA type subunit 1 L homeolog Xenopus laevis 153-156 7476899-8 1995 Evaluation of the glycine-independent component of ethanol inhibition demonstrated that in the presence of saturating concentrations of glycine, the NR1/NR2A and NR1/NR2B receptors were more sensitive to ethanol than the NR1/NR2C and NR1/NR2D receptors. Ethanol 51-58 glutamate ionotropic receptor NMDA type subunit 1 L homeolog Xenopus laevis 162-165 7476899-6 1995 Glycine reversal of ethanol inhibition suggested that ethanol might lower the affinity of glycine for the NMDA receptor and thereby decrease response magnitude. Ethanol 20-27 glutamate ionotropic receptor NMDA type subunit 1 L homeolog Xenopus laevis 106-119 7476899-6 1995 Glycine reversal of ethanol inhibition suggested that ethanol might lower the affinity of glycine for the NMDA receptor and thereby decrease response magnitude. Ethanol 54-61 glutamate ionotropic receptor NMDA type subunit 1 L homeolog Xenopus laevis 106-119 7476899-8 1995 Evaluation of the glycine-independent component of ethanol inhibition demonstrated that in the presence of saturating concentrations of glycine, the NR1/NR2A and NR1/NR2B receptors were more sensitive to ethanol than the NR1/NR2C and NR1/NR2D receptors. Ethanol 51-58 glutamate ionotropic receptor NMDA type subunit 1 L homeolog Xenopus laevis 162-165 7476899-8 1995 Evaluation of the glycine-independent component of ethanol inhibition demonstrated that in the presence of saturating concentrations of glycine, the NR1/NR2A and NR1/NR2B receptors were more sensitive to ethanol than the NR1/NR2C and NR1/NR2D receptors. Ethanol 204-211 glutamate ionotropic receptor NMDA type subunit 1 L homeolog Xenopus laevis 149-152 7476899-8 1995 Evaluation of the glycine-independent component of ethanol inhibition demonstrated that in the presence of saturating concentrations of glycine, the NR1/NR2A and NR1/NR2B receptors were more sensitive to ethanol than the NR1/NR2C and NR1/NR2D receptors. Ethanol 204-211 glutamate ionotropic receptor NMDA type subunit 1 L homeolog Xenopus laevis 162-165 7476899-8 1995 Evaluation of the glycine-independent component of ethanol inhibition demonstrated that in the presence of saturating concentrations of glycine, the NR1/NR2A and NR1/NR2B receptors were more sensitive to ethanol than the NR1/NR2C and NR1/NR2D receptors. Ethanol 204-211 glutamate ionotropic receptor NMDA type subunit 1 L homeolog Xenopus laevis 162-165 7476899-8 1995 Evaluation of the glycine-independent component of ethanol inhibition demonstrated that in the presence of saturating concentrations of glycine, the NR1/NR2A and NR1/NR2B receptors were more sensitive to ethanol than the NR1/NR2C and NR1/NR2D receptors. Ethanol 204-211 glutamate ionotropic receptor NMDA type subunit 1 L homeolog Xenopus laevis 162-165 7476899-10 1995 In addition, nondesensitizing NR1/NR2B responses elicited in the presence of subsaturating concentrations of glycine were frequently converted into desensitizing responses by the addition of ethanol, an effect that was reversed with increasing glycine concentrations. Ethanol 191-198 glutamate ionotropic receptor NMDA type subunit 1 L homeolog Xenopus laevis 30-33 7476899-11 1995 The ability of ethanol to promote glycine-sensitive desensitization further suggests an interaction between glycine and ethanol inhibition of the NMDA receptor. Ethanol 15-22 glutamate ionotropic receptor NMDA type subunit 1 L homeolog Xenopus laevis 146-159 7476899-11 1995 The ability of ethanol to promote glycine-sensitive desensitization further suggests an interaction between glycine and ethanol inhibition of the NMDA receptor. Ethanol 120-127 glutamate ionotropic receptor NMDA type subunit 1 L homeolog Xenopus laevis 146-159 8114679-0 1994 Differential ethanol sensitivity of recombinant N-methyl-D-aspartate receptor subunits. Ethanol 13-20 glutamate ionotropic receptor NMDA type subunit 1 L homeolog Xenopus laevis 48-77 7630488-0 1995 Ethanol sensitivity of heteromeric NMDA receptors: effects of subunit assembly, glycine and NMDAR1 Mg(2+)-insensitive mutants. Ethanol 0-7 glutamate ionotropic receptor NMDA type subunit 1 L homeolog Xenopus laevis 92-98 7630488-1 1995 In the current study, dimeric and trimeric combinations of N-methyl-D-aspartate (NMDA) receptor subunits were expressed in Xenopus oocytes and their sensitivity to ethanol was examined using conventional two electrode voltage clamp methods. Ethanol 164-171 glutamate ionotropic receptor NMDA type subunit 1 L homeolog Xenopus laevis 59-95 7630488-2 1995 In oocytes expressing the NR1/2A subunits, ethanol (25, 50 and 100 mM) inhibited NMDA (100 microM)/glycine (10 microM) induced currents by 21, 31 and 47%; respectively. Ethanol 43-50 glutamate ionotropic receptor NMDA type subunit 1 L homeolog Xenopus laevis 26-32 7630488-4 1995 Ethanol inhibition of NMDA-stimulated currents in oocytes injected with NR1/2A/2B or NR1/2A/2C was not significantly different from that observed in NR1/2B or NR1/2C injected oocytes, respectively. Ethanol 0-7 glutamate ionotropic receptor NMDA type subunit 1 L homeolog Xenopus laevis 72-81 7630488-4 1995 Ethanol inhibition of NMDA-stimulated currents in oocytes injected with NR1/2A/2B or NR1/2A/2C was not significantly different from that observed in NR1/2B or NR1/2C injected oocytes, respectively. Ethanol 0-7 glutamate ionotropic receptor NMDA type subunit 1 L homeolog Xenopus laevis 85-94 7630488-4 1995 Ethanol inhibition of NMDA-stimulated currents in oocytes injected with NR1/2A/2B or NR1/2A/2C was not significantly different from that observed in NR1/2B or NR1/2C injected oocytes, respectively. Ethanol 0-7 glutamate ionotropic receptor NMDA type subunit 1 L homeolog Xenopus laevis 72-75 8114679-5 1994 Different NMDA receptor subunits and subunit combinations exhibited differences in the concentration-response curves for ethanol. Ethanol 121-128 glutamate ionotropic receptor NMDA type subunit 1 L homeolog Xenopus laevis 10-23 8114679-8 1994 Because NMDA receptor subunits are differentially distributed throughout the brain, the observations suggest that the differential sensitivity of NMDA receptor subunits to ethanol may contribute to the differences in ethanol sensitivity observed in different types of neurons. Ethanol 172-179 glutamate ionotropic receptor NMDA type subunit 1 L homeolog Xenopus laevis 8-21 8114679-8 1994 Because NMDA receptor subunits are differentially distributed throughout the brain, the observations suggest that the differential sensitivity of NMDA receptor subunits to ethanol may contribute to the differences in ethanol sensitivity observed in different types of neurons. Ethanol 172-179 glutamate ionotropic receptor NMDA type subunit 1 L homeolog Xenopus laevis 146-159 8114679-8 1994 Because NMDA receptor subunits are differentially distributed throughout the brain, the observations suggest that the differential sensitivity of NMDA receptor subunits to ethanol may contribute to the differences in ethanol sensitivity observed in different types of neurons. Ethanol 217-224 glutamate ionotropic receptor NMDA type subunit 1 L homeolog Xenopus laevis 8-21 8114679-8 1994 Because NMDA receptor subunits are differentially distributed throughout the brain, the observations suggest that the differential sensitivity of NMDA receptor subunits to ethanol may contribute to the differences in ethanol sensitivity observed in different types of neurons. Ethanol 217-224 glutamate ionotropic receptor NMDA type subunit 1 L homeolog Xenopus laevis 146-159 16622040-2 2006 Recently, it was shown that ethanol inhibition of NMDA receptors was reduced by mutation of residues in the transmembrane (TM) segment 3 of the NR1 subunit (F639A) or in TM4 of the NR2A subunit (A825W), suggesting putative ethanol binding sites. Ethanol 28-35 glutamate ionotropic receptor NMDA type subunit 1 L homeolog Xenopus laevis 144-147 7905294-0 1993 Ethanol inhibits glutamate-induced currents in heteromeric NMDA receptor subtypes. Ethanol 0-7 glutamate ionotropic receptor NMDA type subunit 1 L homeolog Xenopus laevis 59-72 7905294-1 1993 Maximal L-glutamate/glycine-evoked currents were inhibited by ethanol in Xenopus laevis oocytes expressing recombinant heteromeric NMDA receptors consisting of NR1-NR2A, NR1-NR2B, and NR1-NR2C subunit combinations. Ethanol 62-69 glutamate ionotropic receptor NMDA type subunit 1 L homeolog Xenopus laevis 160-163 7905294-1 1993 Maximal L-glutamate/glycine-evoked currents were inhibited by ethanol in Xenopus laevis oocytes expressing recombinant heteromeric NMDA receptors consisting of NR1-NR2A, NR1-NR2B, and NR1-NR2C subunit combinations. Ethanol 62-69 glutamate ionotropic receptor NMDA type subunit 1 L homeolog Xenopus laevis 170-173 7905294-1 1993 Maximal L-glutamate/glycine-evoked currents were inhibited by ethanol in Xenopus laevis oocytes expressing recombinant heteromeric NMDA receptors consisting of NR1-NR2A, NR1-NR2B, and NR1-NR2C subunit combinations. Ethanol 62-69 glutamate ionotropic receptor NMDA type subunit 1 L homeolog Xenopus laevis 170-173 7905294-3 1993 The NR1-NR2C channels were slightly less sensitive to ethanol inhibition than the other heteromeric channels in Ca(2+)-deficient, Ba(2+)-containing medium. Ethanol 54-61 glutamate ionotropic receptor NMDA type subunit 1 L homeolog Xenopus laevis 4-7 7905294-4 1993 The inhibition was unaffected by the clamping-voltage and by a mutation [NR1-NR2A(N595Q)] that prevents the Mg(2+)-blockade of the channels, indicating that the mechanism of action of ethanol differs from that of Mg2+. Ethanol 184-191 glutamate ionotropic receptor NMDA type subunit 1 L homeolog Xenopus laevis 73-76 7905294-5 1993 The results are consistent with the hypothesis that the NMDA receptor subtypes can mediate many behavioural actions of ethanol. Ethanol 119-126 glutamate ionotropic receptor NMDA type subunit 1 L homeolog Xenopus laevis 56-69 8515865-3 1993 We have expressed four splice variants of the NMDAR1 subunit in Xenopus oocytes, and find that homomeric assemblies of this subunit, in the absence of other subunits, exhibit ethanol sensitivity comparable to that seen in neurons. Ethanol 175-182 glutamate ionotropic receptor NMDA type subunit 1 L homeolog Xenopus laevis 46-52 18713898-9 2008 Six of seven surfactants, isoflurane, and ethanol inhibited NMDA receptor function. Ethanol 42-49 glutamate ionotropic receptor NMDA type subunit 1 L homeolog Xenopus laevis 60-73 16622040-2 2006 Recently, it was shown that ethanol inhibition of NMDA receptors was reduced by mutation of residues in the transmembrane (TM) segment 3 of the NR1 subunit (F639A) or in TM4 of the NR2A subunit (A825W), suggesting putative ethanol binding sites. Ethanol 223-230 glutamate ionotropic receptor NMDA type subunit 1 L homeolog Xenopus laevis 144-147