PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 28369910-4 2018 In addition, we found that ethanol induced autophagy and cardiac injury largely via the sequential triggering of reactive oxygen species (ROS) accumulation, activation of c-Jun NH2-terminal kinase (JNK), phosphorylation of Bcl-2, and dissociation of the Beclin 1/Bcl-2 complex. Ethanol 27-34 beclin 1, autophagy related Mus musculus 254-262 31376498-10 2019 We determined that the mTOR/BECN1 (S14) pathway is involved in ethanol-induced autophagy in vivo. Ethanol 63-70 beclin 1, autophagy related Mus musculus 28-33 22819980-4 2012 Autophagy was impaired in ethanol-treated KI mice compared to KO mice as reflected by a decline in the LC3-II/LC3-I ratio and lower total LC-3 and Beclin-1 levels coupled to increases in P62, pAKT/AKT and mTOR. Ethanol 26-33 beclin 1, autophagy related Mus musculus 147-155 27070930-5 2016 Our results show that ethanol induces overexpression of several autophagy markers (ATG12, LC3-II, CTSB), and increases the number of lysosomes in WT astrocytes, effects accompanied by a basification of lysosomal pH and by lowered phosphorylation levels of autophagy inhibitor mTOR, along with activation of complexes beclin-1 and ULK1. Ethanol 22-29 beclin 1, autophagy related Mus musculus 317-325