PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 16792571-10 2006 Intracerebellar pretreatment with hexamethonium, a nicotinic receptor (nAChR) antagonist, significantly blocked nicotine-induced attenuation of ethanol ataxia suggesting participation of nAChRs. Ethanol 144-151 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 71-76 16799162-1 2006 AIMS: The stimulatory, rewarding, and dopamine (DA)-enhancing effects of ethanol may involve central nicotinic acetylcholine receptors (nAChR), especially those located in the ventral tegmental area (VTA). Ethanol 73-80 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 136-141 15653713-7 2005 However, ethanol was able to induce fibronectin mRNA and protein in primary lung fibroblasts isolated from alpha(7) nAChR knockout mice. Ethanol 9-16 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 107-121 18826434-0 2009 The alpha 3 subunit gene of the nicotinic acetylcholine receptor is a candidate gene for ethanol stimulation. Ethanol 89-96 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 32-64 15770102-2 2005 Data collected in vitro indicate that physiologically relevant concentrations of ethanol inhibit the functional activation of homomeric alpha7 nAChRs, which are one of the most abundant nAChR subtypes expressed in the mammalian brain. Ethanol 81-88 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 136-142 15770102-3 2005 The studies outlined here used alpha7 gene knockout (null mutant) mice to evaluate the potential role of alpha7 nAChRs in modulating selected behavioral and physiological effects produced by ethanol. Ethanol 191-198 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 105-111 15770102-8 2005 RESULTS: Relative to alpha7(+/+) mice, alpha7(-/-) mice were more sensitive to the activating effects of ethanol on open-field activity, ethanol-induced hypothermia, and duration of loss of the righting response. Ethanol 105-112 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 39-45 15770102-8 2005 RESULTS: Relative to alpha7(+/+) mice, alpha7(-/-) mice were more sensitive to the activating effects of ethanol on open-field activity, ethanol-induced hypothermia, and duration of loss of the righting response. Ethanol 137-144 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 39-45 15770102-11 2005 CONCLUSIONS: These results indicate that some but not all of the behavioral effects of ethanol are mediated in part by effects on nAChRs that include the alpha7 subunit and may help to explain the robust association between alcohol consumption and the use of tobacco. Ethanol 87-94 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 154-160 14610221-2 2004 In vitro studies indicate that nicotinic acetylcholine receptor (nAChR) function is enhanced by ethanol. Ethanol 96-103 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 31-63 14610221-2 2004 In vitro studies indicate that nicotinic acetylcholine receptor (nAChR) function is enhanced by ethanol. Ethanol 96-103 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 65-70 14610221-3 2004 Furthermore, some ethanol-related behaviors are associated with a region of mouse chromosome 2 that contains the gene encoding the alpha4 subunit of the nAChR (Chrna4). Ethanol 18-25 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 153-158 15555774-1 2005 The alpha7 subtype of nicotinic acetylcholine receptor (nAChR) has been implicated as a potential site of action for two neurotoxins, ethanol and the Alzheimer"s disease related peptide, beta-amyloid. Ethanol 134-141 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 56-61 15555774-3 2005 Knockout of the alpha7 nAChR gene selectively enhanced ethanol-induced neurotoxicity in a gene dosage-related fashion. Ethanol 55-62 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 16-28 15555774-6 2005 On the other hand, in studies in Xenopus oocytes ethanol efficaciously inhibited alpha7 nAChR function. Ethanol 49-56 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 88-93 14691373-1 2003 BACKGROUND: Ethanol modulates the functional activity of alpha4beta2 neuronal nicotinic cholinergic receptors (nAChR) when measured in vitro, but the potential role of alpha4beta2 nAChRs in regulating behavioral effects of ethanol is unknown. Ethanol 12-19 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 69-109 14691373-1 2003 BACKGROUND: Ethanol modulates the functional activity of alpha4beta2 neuronal nicotinic cholinergic receptors (nAChR) when measured in vitro, but the potential role of alpha4beta2 nAChRs in regulating behavioral effects of ethanol is unknown. Ethanol 12-19 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 111-116 12766617-1 2003 BACKGROUND: Several studies indicate that ethanol enhances the activity of alpha4beta2 nicotinic acetylcholine receptors (nAChR). Ethanol 42-49 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 122-127 12766617-5 2003 METHODS: We have used the 86Rb+ efflux method to study the acute effects of ethanol on the function of the alpha4beta2 nAChR in the thalamus in six different mouse strains. Ethanol 76-83 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 119-124 12766617-10 2003 Experiments with the F2 hybrids demonstrated that one copy of the A polymorphism was sufficient to produce a significant enhancement of nAChR function by ethanol (50 mM) in animals that were also beta2 +/+. Ethanol 154-161 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 136-141 12766617-12 2003 CONCLUSIONS: The results suggest that the A/T polymorphism influences the initial sensitivity of the alpha4beta2 nAChR to ethanol. Ethanol 122-129 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 113-118 18826434-2 2009 A gene in a region of mouse chromosome 9 that includes a cluster of three nicotinic acetylcholine receptor (nAChR) subunit genes influences the locomotor stimulant response to ethanol. Ethanol 176-183 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 108-113 18826434-7 2009 Congenic data indicate that a gene on chromosome 9, within a 46 cM region that contains the cluster of nAChR subunit genes, accounts for 41% of the genetic variation in the stimulant response to ethanol. Ethanol 195-202 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 103-108 18826434-2 2009 A gene in a region of mouse chromosome 9 that includes a cluster of three nicotinic acetylcholine receptor (nAChR) subunit genes influences the locomotor stimulant response to ethanol. Ethanol 176-183 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 74-106 35189673-9 2022 CONCLUSION AND IMPLICATIONS: Inhibition of KMO reduces ethanol consumption and preference in both male and female mice subjected to CIE model by a mechanism involving alpha7nAChR. Ethanol 55-62 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 167-178 31580099-8 2019 Our results support the involvement of alpha3beta4 nAChR in the expression of ethanol-induced locomotor sensitization and suggest that 18-MC may be a therapeutic for AUD. Ethanol 78-85 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 51-56 30496781-3 2019 Growing research suggests that 18-Methoxycoronaridine (18-MC), an alpha3beta4 nicotinic acetylcholine receptor (nAChR) antagonist, may be effective at reducing ethanol consumption. Ethanol 160-167 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 112-117 29114204-3 2017 Effects of ethanol on specific brain nAChR subtypes within the mesolimbic dopaminergic (DA) pathway may be a key element in the comorbidity of ethanol and nicotine. Ethanol 11-18 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 37-42 29944862-2 2018 The alpha5 nAChR subunit has also recently been shown to modulate some of the acute response to ethanol in mice. Ethanol 96-103 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 11-16 29944862-7 2018 We found that deletion of the alpha5 nAChR subunit enhanced ethanol-induced hypothermia, hypnosis, and an anxiolytic-like response in comparison to wild-type controls. Ethanol 60-67 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 37-42 28778837-3 2018 Throughout adolescence, nAChR expression undergoes large-scale developmental changes which may alter behavioral responses to ethanol. Ethanol 125-132 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 24-29 29293602-5 2018 This indicates that a component of the bitter taste of ethanol is also nAChR-dependent. Ethanol 55-62 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 71-76 29293602-13 2018 We conclude that nAChR subunits are expressed in Trpm5-positive TRCs and their expression levels are differentially altered by chronic oral exposure to nicotine and ethanol. Ethanol 165-172 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 17-22 29114204-3 2017 Effects of ethanol on specific brain nAChR subtypes within the mesolimbic dopaminergic (DA) pathway may be a key element in the comorbidity of ethanol and nicotine. Ethanol 143-150 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 37-42 29114204-5 2017 In the present study, we measured the effect of acute binge ethanol on nAChR alpha4 subunit levels in the prefrontal cortex (PFC), nucleus accumbens (NAc), ventral tegmental area (VTA), and amygdala (Amg) by western blot analysis using a knock-in mouse line, generated with a normally functioning alpha4 nAChR subunit tagged with yellow fluorescent protein (YFP). Ethanol 60-67 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 71-76 27793544-3 2016 Recent evidence suggests that ethanol may potentiate ACh activation of these receptors as well, although whether alpha6* nAChR expression is necessary for behavioral effects of acute ethanol exposure is unknown. Ethanol 183-190 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 113-126 23811312-3 2013 Recent evidence indicates that nicotinic acetylcholine receptors (nAChRs), ligand-gated cation channels activated by ACh and nicotine, may contribute to ethanol-mediated activation of VTA DAergic neurons although the nAChR subtype(s) involved has not been fully elucidated. Ethanol 153-160 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 66-71 26428091-3 2016 Past studies report that nicotine and ethanol activate dopamine neurons in the reward pathway and may increase synaptic levels of dopamine in the nucleus accumbens through nicotinic acetylcholine receptor (nAChR) stimulation. Ethanol 38-45 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 172-204 26428091-3 2016 Past studies report that nicotine and ethanol activate dopamine neurons in the reward pathway and may increase synaptic levels of dopamine in the nucleus accumbens through nicotinic acetylcholine receptor (nAChR) stimulation. Ethanol 38-45 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 206-211 26428091-9 2016 Autoradiographic analysis of nAChR density revealed higher epibatidine binding in frontal cortical regions in mice exposed to nicotine and ethanol compared to mice exposed to ethanol only. Ethanol 139-146 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 29-34 24643637-7 2014 Furthermore, the nonspecific nAChR antagonist mecamylamine (2 mg/kg) blocked the effects of ethanol in the core in vivo. Ethanol 92-99 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 29-34 23811312-7 2013 Ethanol-induced activity in WT slices was also reduced by pre-application of the alpha6 subtype-selective nAChR antagonist, alpha-conotoxin MII[E11A]. Ethanol 0-7 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 106-111 23872372-2 2013 Pre-clinical and clinical studies have shown that neuronal nicotinic acetylcholine receptor (nAChR) partial agonists such as cytisine and its derivative, varenicline, reduce alcohol (ethanol) consumption and seeking behavior. Ethanol 183-190 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 59-91 23872372-2 2013 Pre-clinical and clinical studies have shown that neuronal nicotinic acetylcholine receptor (nAChR) partial agonists such as cytisine and its derivative, varenicline, reduce alcohol (ethanol) consumption and seeking behavior. Ethanol 183-190 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 93-98 23872372-9 2013 The results from this study indicate that nAChR partial agonists reduce the expression of ADE in mice and further suggest the involvement of nAChR mechanisms in ADE, a relapse-like ethanol drinking behavior. Ethanol 181-188 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 42-47 23872372-9 2013 The results from this study indicate that nAChR partial agonists reduce the expression of ADE in mice and further suggest the involvement of nAChR mechanisms in ADE, a relapse-like ethanol drinking behavior. Ethanol 181-188 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 141-146 21143250-0 2011 The role of nicotinic acetylcholine receptor (nAChR) alpha7 subtype in the functional interaction between nicotine and ethanol in mouse cerebellum. Ethanol 119-126 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 12-44 23601929-3 2013 Previously, we have shown that cytisine, a neuronal nicotinic acetylcholine receptor (nAChR) partial agonist, reduces various ethanol-drinking behaviors and ethanol-induced striatal dopamine function. Ethanol 126-133 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 86-91 23601929-3 2013 Previously, we have shown that cytisine, a neuronal nicotinic acetylcholine receptor (nAChR) partial agonist, reduces various ethanol-drinking behaviors and ethanol-induced striatal dopamine function. Ethanol 157-164 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 86-91 23419392-2 2013 The beta2* nAChR subtype serves as a potential interface for these interactions since they are the principle mediators of nicotine dependence and have recently been shown to modulate some acute responses to ethanol. Ethanol 207-214 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 11-16 23419392-4 2013 We conducted a battery of tests in mice lacking the beta2* coding gene (Chrnb2) or pretreated with a selective beta2* nAChR antagonist for a range of ethanol-induced behaviors including locomotor depression, hypothermia, hypnosis, and anxiolysis. Ethanol 150-157 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 118-123 22458409-4 2012 Here, we tested in fetal NSCs the extent to which EtOH and nicotine coregulated known EtOH-sensitive (miR-9, miR-21, miR-153, and miR-335), a nicotine-sensitive miRNA (miR-140-3p), and mRNAs for nicotinic acetylcholine receptor (nAChR) subunits. Ethanol 50-54 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 195-227 22458409-4 2012 Here, we tested in fetal NSCs the extent to which EtOH and nicotine coregulated known EtOH-sensitive (miR-9, miR-21, miR-153, and miR-335), a nicotine-sensitive miRNA (miR-140-3p), and mRNAs for nicotinic acetylcholine receptor (nAChR) subunits. Ethanol 50-54 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 229-234 22458409-4 2012 Here, we tested in fetal NSCs the extent to which EtOH and nicotine coregulated known EtOH-sensitive (miR-9, miR-21, miR-153, and miR-335), a nicotine-sensitive miRNA (miR-140-3p), and mRNAs for nicotinic acetylcholine receptor (nAChR) subunits. Ethanol 86-90 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 195-227 22458409-4 2012 Here, we tested in fetal NSCs the extent to which EtOH and nicotine coregulated known EtOH-sensitive (miR-9, miR-21, miR-153, and miR-335), a nicotine-sensitive miRNA (miR-140-3p), and mRNAs for nicotinic acetylcholine receptor (nAChR) subunits. Ethanol 86-90 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 229-234 22458409-10 2012 Finally, EtOH decreased the expression of nAChR subunit mRNAs and, like mecamylamine, prevented the nicotine-associated increase in alpha4 and beta2 nAChR transcripts. Ethanol 9-13 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 42-47 22458409-10 2012 Finally, EtOH decreased the expression of nAChR subunit mRNAs and, like mecamylamine, prevented the nicotine-associated increase in alpha4 and beta2 nAChR transcripts. Ethanol 9-13 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 149-154 22458409-11 2012 CONCLUSIONS: EtOH and nicotine exert mutually antagonistic, nAChR-mediated effects on teratogen-sensitive miRNAs in fetal NSCs. Ethanol 13-17 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 60-65 21239887-6 2011 Consistent with this result, here we show that a more efficacious nAChR agonist, nicotine, also decreased voluntary ethanol intake, and that alpha4* nAChRs are critical for this reduction. Ethanol 116-123 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 66-71 22741175-2 2012 The present study examined the efficacy of nAChR ligands with different pharmacological profiles such as cytisine, lobeline and dihydro-beta-erythroidine (DHbetaE) to modulate chronic nicotine-induced increase in ethanol intake by C57BL/6J mice, using a two-bottle choice procedure. Ethanol 213-220 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 43-48 20974182-0 2011 Role of mouse cerebellar nicotinic acetylcholine receptor (nAChR) alpha(4)beta(2)- and alpha(7) subtypes in the behavioral cross-tolerance between nicotine and ethanol-induced ataxia. Ethanol 160-167 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 25-57 20974182-0 2011 Role of mouse cerebellar nicotinic acetylcholine receptor (nAChR) alpha(4)beta(2)- and alpha(7) subtypes in the behavioral cross-tolerance between nicotine and ethanol-induced ataxia. Ethanol 160-167 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 59-64 20974182-1 2011 We have demonstrated that nicotine attenuated ethanol-induced ataxia via nicotinic-acetylcholine-receptor (nAChR) subtypes alpha(4)beta(2) and alpha(7). Ethanol 46-53 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 107-112 20974182-15 2011 Our results support a role for alpha(4)beta(2) and alpha(7) nAChR subtypes in the development of cross-tolerance between nicotine and ethanol with the NO signaling pathway as a potential mechanism. Ethanol 134-141 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 51-65 21143250-0 2011 The role of nicotinic acetylcholine receptor (nAChR) alpha7 subtype in the functional interaction between nicotine and ethanol in mouse cerebellum. Ethanol 119-126 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 46-51 21143250-4 2011 The intracerebellar (ICB) administration of nicotine significantly attenuates ethanol ataxia through nicotinic acetylcholine receptor (nAChR) alpha(4)beta(2) subtype. Ethanol 78-85 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 101-133 21143250-4 2011 The intracerebellar (ICB) administration of nicotine significantly attenuates ethanol ataxia through nicotinic acetylcholine receptor (nAChR) alpha(4)beta(2) subtype. Ethanol 78-85 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 135-140 21143250-5 2011 This study, an extension of earlier work, was intended to investigate the possible role of nAChR subtype alpha(7) in mitigating ethanol ataxia. Ethanol 128-135 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 91-96 21143250-14 2011 Overall, the results demonstrate the role of cerebellar nAChR alpha(7) subtype in nicotine-induced attenuation of ethanol-induced ataxia in cerebellar NO(x)-sensitive manner. Ethanol 114-121 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 56-61 21111768-7 2011 These findings provide evidence that nAChR-mediated signaling plays a critical role in ethanol drinking behavior in mice and nicotinic ligands have therapeutic potential for cessation of binge-like ethanol drinking and dependence in humans. Ethanol 87-94 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 37-42 21111768-7 2011 These findings provide evidence that nAChR-mediated signaling plays a critical role in ethanol drinking behavior in mice and nicotinic ligands have therapeutic potential for cessation of binge-like ethanol drinking and dependence in humans. Ethanol 198-205 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 37-42 20580908-1 2010 Several evidences have indicated the involvement of neuronal nicotinic acetylcholine receptors (nAChR) in behavioral effects of drugs of abuse, including ethanol. Ethanol 154-161 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 61-94 20580908-1 2010 Several evidences have indicated the involvement of neuronal nicotinic acetylcholine receptors (nAChR) in behavioral effects of drugs of abuse, including ethanol. Ethanol 154-161 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 96-101 20072781-4 2010 OBJECTIVE: The aim of this study was to examine the role of nAChRs containing alpha7 or beta2 subunits in ethanol consumption. Ethanol 106-113 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 78-84 20168214-2 2010 Therefore, this study evaluated the effects of mecamylamine, a nAChR antagonist, on ethanol withdrawal signs. Ethanol 84-91 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 63-68 20168214-7 2010 In addition, chronic administration of mecamylamine into ethanol diet-fed mice markedly attenuated the ethanol withdrawal sign scores, thus supporting the contention that nAChR is involved in ethanol dependence. Ethanol 57-64 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 171-176 20168214-7 2010 In addition, chronic administration of mecamylamine into ethanol diet-fed mice markedly attenuated the ethanol withdrawal sign scores, thus supporting the contention that nAChR is involved in ethanol dependence. Ethanol 103-110 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 171-176 20168214-7 2010 In addition, chronic administration of mecamylamine into ethanol diet-fed mice markedly attenuated the ethanol withdrawal sign scores, thus supporting the contention that nAChR is involved in ethanol dependence. Ethanol 103-110 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 171-176 20168214-8 2010 In conclusion, our results suggest that mecamylamine exhibited inhibitory effects on ethanol withdrawal signs which could be mediated through nAChR. Ethanol 85-92 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 142-147 20072781-11 2010 CONCLUSIONS: This study provides evidence that alpha7 nAChRs are involved in ethanol consumption and supports the idea that pharmacological manipulation of nAChRs reduces ethanol intake. Ethanol 77-84 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 47-53 20072781-11 2010 CONCLUSIONS: This study provides evidence that alpha7 nAChRs are involved in ethanol consumption and supports the idea that pharmacological manipulation of nAChRs reduces ethanol intake. Ethanol 171-178 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 47-53 20072781-8 2010 In contrast, mice lacking the alpha7 nAChR receptor subunit consumed significantly less ethanol than wild-type mice but consumed comparable amounts of water, saccharin, and quinine. Ethanol 88-95 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 30-36 20072781-8 2010 In contrast, mice lacking the alpha7 nAChR receptor subunit consumed significantly less ethanol than wild-type mice but consumed comparable amounts of water, saccharin, and quinine. Ethanol 88-95 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 37-42 19501109-2 2009 However, discernment of nAChR contribution to ethanol reinforcement and consumption remains incomplete. Ethanol 46-53 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 24-29 19465085-9 2009 NIC and NIC+ETOH promoted nAChR upregulation during a short-term withdrawal. Ethanol 12-16 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 26-31 19501109-12 2009 Assessment of drinking topography within an operant self-administration procedure may provide useful insights regarding the role of nAChR function in the regulation of ethanol consumption. Ethanol 168-175 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 132-137 18411066-2 2008 Varenicline, an alpha4beta2 nicotinic receptor partial agonist and alpha7 nicotinic receptor full agonist prescribed for smoking cessation, has been shown to decrease ethanol consumption. Ethanol 167-174 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 67-92 18812210-0 2008 Attenuation of ethanol-induced ataxia by alpha(4)beta(2) nicotinic acetylcholine receptor subtype in mouse cerebellum: a functional interaction. Ethanol 15-22 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 57-89 18812210-3 2008 The present study was designed to determine the possible involvement of specific nicotinic acetylcholine receptor (nAChR) subtype alpha(4)beta(2) in nicotine-induced attenuation of ethanol ataxia. Ethanol 181-188 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 81-113 18812210-3 2008 The present study was designed to determine the possible involvement of specific nicotinic acetylcholine receptor (nAChR) subtype alpha(4)beta(2) in nicotine-induced attenuation of ethanol ataxia. Ethanol 181-188 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 115-120 18812210-11 2008 In conclusion, the results of the present investigation support an important role of alpha(4)beta(2) nAChR subtype in the expression of nicotine-induced attenuation of ethanol ataxia. Ethanol 168-175 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 101-106