PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 23895284-1 2013 BACKGROUND: Ethanol (EtOH) decreases muscle protein synthesis, and this is associated with reduced mammalian target of rapamycin complex (mTORC)1 and increased mTORC2 activities. Ethanol 12-19 CREB regulated transcription coactivator 1 Mus musculus 138-145 26955879-8 2016 Further studies on signaling pathway demonstrated that ethanol extract treatment might inhibit urinary bladder urothelial carcinoma cell proliferation through restriction of PTEN/AKT/mTORC1 pathway via profilin 1 up-regulation. Ethanol 55-62 CREB regulated transcription coactivator 1 Mus musculus 183-189 25849580-6 2015 RESULTS: Treatment of DLBCL cells with EtOH suppressed mTORC1 complex formation while increasing AKT phosphorylation and mTORC2 complex assembly. Ethanol 39-43 CREB regulated transcription coactivator 1 Mus musculus 55-61 25623400-9 2015 CONCLUSIONS: These data suggest that EtOH-induced decreases in protein synthesis in fasted mice may be independent of mTORC1 and MAPK signaling following muscle contraction and instead due to the antagonistic actions of EtOH on mRNA translation elongation. Ethanol 37-41 CREB regulated transcription coactivator 1 Mus musculus 118-124 28299793-2 2017 EtOH impairs protein synthesis in C2C12 myoblasts via a FoxO1-AMPK-TSC2-mTORC1 pathway and also induces protein degradation. Ethanol 0-4 CREB regulated transcription coactivator 1 Mus musculus 72-78 23895284-1 2013 BACKGROUND: Ethanol (EtOH) decreases muscle protein synthesis, and this is associated with reduced mammalian target of rapamycin complex (mTORC)1 and increased mTORC2 activities. Ethanol 21-25 CREB regulated transcription coactivator 1 Mus musculus 138-145 23895284-18 2013 EtOH and PA regulate mTORC1 via a PI3K/AMPK/TSC2/PLD signaling cascade. Ethanol 0-4 CREB regulated transcription coactivator 1 Mus musculus 21-27 22442136-14 2012 Collectively, our results indicate that EtOH inhibits the anabolic effects that Leu has on protein synthesis and mTORC1 activity by modulating both Rag GTPase function and AMPK/TSC2/Rheb signaling. Ethanol 40-44 CREB regulated transcription coactivator 1 Mus musculus 113-119 22451512-10 2012 CONCLUSION: In summary, these data suggest that ethanol exposure may trigger myocardial dysfunction through a mechanism associated with AMPK-mTORC1-ULK1-mediated autophagy. Ethanol 48-55 CREB regulated transcription coactivator 1 Mus musculus 141-147 20127721-3 2010 However, the mechanisms by which EtOH regulates mTORC1 activity have not been established. Ethanol 33-37 CREB regulated transcription coactivator 1 Mus musculus 48-54 21438886-2 2011 We reported that alcohol (EtOH) inhibits mTORC1 activity and protein synthesis in C2C12 myoblasts. Ethanol 26-30 CREB regulated transcription coactivator 1 Mus musculus 41-47 20127721-4 2010 Here, we investigated the effect of EtOH on the phosphorylation and interaction of components of mTORC1 in C2C12 myocytes. Ethanol 36-40 CREB regulated transcription coactivator 1 Mus musculus 97-103 20127721-8 2010 EtOH also caused changes in mTORC1 protein-protein interactions. Ethanol 0-4 CREB regulated transcription coactivator 1 Mus musculus 28-34 34267188-8 2021 The pathological effect of sustained mTORC1 activity in ALD may be attributed to the suppression of peroxisome proliferator activated receptor alpha (PPARalpha), the master regulator of fatty acid oxidation in hepatocytes, because fenofibrate (PPARalpha agonist) treatment reverses ethanol-induced liver steatosis and inflammation in Depdc5-LKO mice. Ethanol 282-289 CREB regulated transcription coactivator 1 Mus musculus 37-43 34439466-2 2021 Here, we found that an ethanol extract of tartary buckwheat (TBE) potently induced autophagy flux in HeLa cells by suppressing mTORC1 activity, as revealed by dephosphorylation of the mTORC1 substrates Ulk1, S6K, and 4EBP, as well as by the nuclear translocation of transcriptional factor EB. Ethanol 23-30 CREB regulated transcription coactivator 1 Mus musculus 127-133 34439466-2 2021 Here, we found that an ethanol extract of tartary buckwheat (TBE) potently induced autophagy flux in HeLa cells by suppressing mTORC1 activity, as revealed by dephosphorylation of the mTORC1 substrates Ulk1, S6K, and 4EBP, as well as by the nuclear translocation of transcriptional factor EB. Ethanol 23-30 CREB regulated transcription coactivator 1 Mus musculus 184-190 34267188-3 2021 In the current study, we found that aberrant activation of mTORC1 was likely attributed to the reduction of DEPDC5 in the livers of ethanol-fed mice or ALD patients. Ethanol 132-139 CREB regulated transcription coactivator 1 Mus musculus 59-65 32799332-2 2021 We determined the mechanisms of ethanol-induced impaired phosphorylation of mechanistic target of rapamycin complex 1 (mTORC1) and AMP kinase (AMPK) with consequent dysregulated skeletal muscle protein homeostasis (balance between protein synthesis and breakdown). Ethanol 32-39 CREB regulated transcription coactivator 1 Mus musculus 119-125 32799332-4 2021 Ethanol increases skeletal muscle autophagy by dephosphorylating mTORC1, circumventing the classical kinase regulation by protein kinase B (Akt). Ethanol 0-7 CREB regulated transcription coactivator 1 Mus musculus 65-71 32799332-5 2021 Concurrently and paradoxically, ethanol exposure results in dephosphorylation and inhibition of AMPK, an activator of autophagy and inhibitor of mTORC1 signaling. Ethanol 32-39 CREB regulated transcription coactivator 1 Mus musculus 145-151 32799332-8 2021 Ethanol impairs binding of endogenous inhibitor of PP2A (I2-PP2A) to PP2A resulting in methylation and targeting of PP2A to cause dephosphorylation of mTORC1 and AMPK. Ethanol 0-7 CREB regulated transcription coactivator 1 Mus musculus 151-157 33543862-6 2021 RESULTS: Multiomics analyses showed that ethanol impaired skeletal muscle mTORC1 signaling, mitochondrial oxidative pathways, including intermediary metabolite regulatory genes, interleukin-6, and amino acid degradation pathways are beta-hydroxymethyl-butyrate targets. Ethanol 41-48 CREB regulated transcription coactivator 1 Mus musculus 74-80 33673489-12 2021 This suggests the involvement of mTORC1 in the deleterious effect of ethanol on the developing brain. Ethanol 69-76 CREB regulated transcription coactivator 1 Mus musculus 33-39 33543862-7 2021 Ethanol decreased mTORC1 signaling, increased autophagy flux, impaired mitochondrial oxidative function with decreased tricarboxylic acid cycle intermediary metabolites, ATP synthesis, protein synthesis and myotube diameter that were reversed by HMB. Ethanol 0-7 CREB regulated transcription coactivator 1 Mus musculus 18-24 32966340-12 2020 Taken together, acute EtOH exposure leads to mitochondrial dysfunction and oxidative stress in esophageal keratinocytes, where the AMPK-mTORC1 axis may serve as a regulatory mechanism to activate autophagy to provide cytoprotection against EtOH-induced cell injury. Ethanol 22-26 CREB regulated transcription coactivator 1 Mus musculus 136-142 32966340-12 2020 Taken together, acute EtOH exposure leads to mitochondrial dysfunction and oxidative stress in esophageal keratinocytes, where the AMPK-mTORC1 axis may serve as a regulatory mechanism to activate autophagy to provide cytoprotection against EtOH-induced cell injury. Ethanol 240-244 CREB regulated transcription coactivator 1 Mus musculus 136-142 31377562-1 2019 BACKGROUND: Excessive consumption of ethanol is known to activate the mTORC1 pathway and to enhance the Collapsin Response Mediator Protein-2 (CRMP-2) levels in the limbic region of brain. Ethanol 37-44 CREB regulated transcription coactivator 1 Mus musculus 70-76 31637215-6 2019 Next, out of Cat-GS, we established two key regulators of alcohol metabolism, alcohol dehydrogenase 1A (ADH1A) and aldehyde dehydrogenase 2 (ALDH2), as being transcriptionally suppressed by histone deacetylase 1 (HDAC1) at the downstream of mTORC1 signaling. Ethanol 58-65 CREB regulated transcription coactivator 1 Mus musculus 241-247 30872403-8 2019 Simultaneous ethanol and ammonia treatment impaired protein synthesis and mTORC1 signaling and increased autophagy with a consequent decreased myotube diameter to a greater extent than either treatment alone. Ethanol 13-20 CREB regulated transcription coactivator 1 Mus musculus 74-80 29457836-4 2018 Chronic-plus-binge ethanol feeding led to hyperactivation of mTORC1, as evidenced by increased phosphorylation of mTOR and its downstream kinase S6 kinase 1 (S6K1) in hepatocytes. Ethanol 19-26 CREB regulated transcription coactivator 1 Mus musculus 61-67 29457836-5 2018 Aberrant activation of mTORC1 was likely attributed to the defects of the DEP domain-containing mTOR-interacting protein (DEPTOR) and the nicotinamide adenine dinucleotide-dependent deacetylase sirtuin 1 (SIRT1) in the liver of chronic-plus-binge ethanol-fed mice and in the liver of patients with ALD. Ethanol 247-254 CREB regulated transcription coactivator 1 Mus musculus 23-29