PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
25943301-0	2015	The natural yeast extract isolated by ethanol precipitation inhibits melanin synthesis by modulating tyrosinase activity and downregulating melanosome transfer.	Ethanol	38-45	tyrosinase	Mus musculus	101-111	
27084445-0	2016	Inhibitory effect of Cinnamomum osmophloeum Kanehira ethanol extracts on melanin synthesis via repression of tyrosinase expression.	Ethanol	53-60	tyrosinase	Mus musculus	109-119	
27084445-8	2016	In addition to the melanin content, greater than 20% of the tyrosinase activity was inhibited by these ethanol extracts.	Ethanol	103-110	tyrosinase	Mus musculus	60-70	
30297610-3	2018	The ethyl acetate fraction of the initial ethanol extract decreased the activity of tyrosinase, a key enzyme in the synthetic pathway of melanin.	Ethanol	42-49	tyrosinase	Mus musculus	84-94	
16946515-11	2006	Among them, water extract of Galla Chinensis and ethanol extract of Radix Clematidis exhibited higher depigmentation activity and caused lower tyrosinase activity in cell culture assays and are worthy to be further studied.	Ethanol	49-56	tyrosinase	Mus musculus	143-153	
21389613-3	2011	We also found that this 50% ethanol eluate reduced the intracellular tyrosinase activity and also had a direct inhibitory effect on tyrosinase obtained as a protein mixture from the melanoma cell lysate.	Ethanol	28-35	tyrosinase	Mus musculus	69-79	
21389613-3	2011	We also found that this 50% ethanol eluate reduced the intracellular tyrosinase activity and also had a direct inhibitory effect on tyrosinase obtained as a protein mixture from the melanoma cell lysate.	Ethanol	28-35	tyrosinase	Mus musculus	132-142