PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 23538902-0 2013 Inhibition of Wee1, AKT, and CDK4 underlies the efficacy of the HSP90 inhibitor XL888 in an in vivo model of NRAS-mutant melanoma. XL 888 80-85 AKT serine/threonine kinase 1 Homo sapiens 20-23 23538902-9 2013 In vivo, XL888 treatment led to degradation of CDK4 and Wee1 and the inhibition of AKT/S6 signaling with little or no effect observed upon ARAF, CRAF, or MAPK. XL 888 9-14 AKT serine/threonine kinase 1 Homo sapiens 83-86