PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
11689424-1	2001	Uroporphyrinogen III synthase, U3S, the fourth enzyme in the porphyrin biosynthetic pathway, catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrino gen III, which is used in several different pathways to form heme, siroheme, chlorophyll, F(430) and vitamin B(12).	Tetrapyrroles	129-141	uroporphyrinogen III synthase	Homo sapiens	0-29	
19021769-2	2008	Hydroxymethylbilane synthase (HMBS) and uroporphyrinogen III synthase (UROS) catalyze two consecutive reactions in the heme biosynthetic pathway, generating the first linear and the first cyclic tetrapyrroles, respectively.	Tetrapyrroles	195-208	uroporphyrinogen III synthase	Homo sapiens	40-69	
19021769-2	2008	Hydroxymethylbilane synthase (HMBS) and uroporphyrinogen III synthase (UROS) catalyze two consecutive reactions in the heme biosynthetic pathway, generating the first linear and the first cyclic tetrapyrroles, respectively.	Tetrapyrroles	195-208	uroporphyrinogen III synthase	Homo sapiens	71-75	
12196144-6	2002	The final common biosynthetic step in tetrapyrrole biosynthesis is the generation of uroporphyrinogen by uroporphyrinogen III synthase, whereby the D ring of hydroxymethylbilane is flipped during ring closure to generate the asymmetrical structure of uroporphyrinogen III.	Tetrapyrroles	38-50	uroporphyrinogen III synthase	Homo sapiens	105-134	
32457103-0	2020	The uroporphyrinogen-III synthase (uroS) and the magnesium chelatase class of AAA+ ATPase (yifB) genes conserved among tetrapyrrole synthesizing-deficient Bacteroidales are involved in Bacteroides fragilis heme assimilation and survival in experimental intra-abdominal infection and intestinal colonization.	Tetrapyrroles	119-131	uroporphyrinogen III synthase	Homo sapiens	4-33	
3174619-1	1988	Uroporphyrinogen III synthase [URO-synthase; hydroxymethylbilane hydro-lyase (cyclizing), EC 4.2.1.75], the fourth enzyme in the heme biosynthetic pathway, is responsible for conversion of the linear tetrapyrrole, hydroxymethylbilane, to the cyclic tetrapyrrole, uroporphyrinogen III.	Tetrapyrroles	200-212	uroporphyrinogen III synthase	Homo sapiens	0-29	
3174619-1	1988	Uroporphyrinogen III synthase [URO-synthase; hydroxymethylbilane hydro-lyase (cyclizing), EC 4.2.1.75], the fourth enzyme in the heme biosynthetic pathway, is responsible for conversion of the linear tetrapyrrole, hydroxymethylbilane, to the cyclic tetrapyrrole, uroporphyrinogen III.	Tetrapyrroles	200-212	uroporphyrinogen III synthase	Homo sapiens	45-76	
32457103-0	2020	The uroporphyrinogen-III synthase (uroS) and the magnesium chelatase class of AAA+ ATPase (yifB) genes conserved among tetrapyrrole synthesizing-deficient Bacteroidales are involved in Bacteroides fragilis heme assimilation and survival in experimental intra-abdominal infection and intestinal colonization.	Tetrapyrroles	119-131	uroporphyrinogen III synthase	Homo sapiens	35-39