PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
15381398-1	2004	Porphobilinogen synthase (PBGS) catalyzes the first common reaction in the biosynthesis of the tetrapyrroles, the asymmetric condensation of two molecules of delta-aminolevulinic acid to form porphobilinogen.	Tetrapyrroles	95-108	aminolevulinate dehydratase	Homo sapiens	0-24	
15381398-1	2004	Porphobilinogen synthase (PBGS) catalyzes the first common reaction in the biosynthesis of the tetrapyrroles, the asymmetric condensation of two molecules of delta-aminolevulinic acid to form porphobilinogen.	Tetrapyrroles	95-108	aminolevulinate dehydratase	Homo sapiens	26-30	
11444968-2	2001	PBGS catalyzes the first common step in the biosynthesis of the tetrapyrrole cofactors such as heme, vitamin B(12), and chlorophyll.	Tetrapyrroles	64-76	aminolevulinate dehydratase	Homo sapiens	0-4	
12897770-0	2003	Control of tetrapyrrole biosynthesis by alternate quaternary forms of porphobilinogen synthase.	Tetrapyrroles	11-23	aminolevulinate dehydratase	Homo sapiens	70-94	
12897770-1	2003	Porphobilinogen synthase (PBGS) catalyzes the first common step in the biosynthesis of tetrapyrroles (such as heme and chlorophyll).	Tetrapyrroles	87-100	aminolevulinate dehydratase	Homo sapiens	0-24	
12897770-1	2003	Porphobilinogen synthase (PBGS) catalyzes the first common step in the biosynthesis of tetrapyrroles (such as heme and chlorophyll).	Tetrapyrroles	87-100	aminolevulinate dehydratase	Homo sapiens	26-30	
12897770-6	2003	The unprecedented structural rearrangement reported here relates to the allosteric regulation of PBGS and suggests that alternative PBGS oligomers may function in a magnesium-dependent regulation of tetrapyrrole biosynthesis in plants and some bacteria.	Tetrapyrroles	199-211	aminolevulinate dehydratase	Homo sapiens	97-101	
12897770-6	2003	The unprecedented structural rearrangement reported here relates to the allosteric regulation of PBGS and suggests that alternative PBGS oligomers may function in a magnesium-dependent regulation of tetrapyrrole biosynthesis in plants and some bacteria.	Tetrapyrroles	199-211	aminolevulinate dehydratase	Homo sapiens	132-136	
12573695-1	2003	Porphobilinogen synthase (PBGS), which catalyzes the first common step in tetrapyrrole biosynthesis, contains a unique phylogenetic variation in the use of metal ions.	Tetrapyrroles	74-86	aminolevulinate dehydratase	Homo sapiens	0-24	
12573695-1	2003	Porphobilinogen synthase (PBGS), which catalyzes the first common step in tetrapyrrole biosynthesis, contains a unique phylogenetic variation in the use of metal ions.	Tetrapyrroles	74-86	aminolevulinate dehydratase	Homo sapiens	26-30	
12459913-1	2003	Porphobilinogen synthase (PBGS) is an ancient and highly conserved protein that functions in the first common step in tetrapyrrole biosynthesis.	Tetrapyrroles	118-130	aminolevulinate dehydratase	Homo sapiens	0-24	
12459913-1	2003	Porphobilinogen synthase (PBGS) is an ancient and highly conserved protein that functions in the first common step in tetrapyrrole biosynthesis.	Tetrapyrroles	118-130	aminolevulinate dehydratase	Homo sapiens	26-30	
11909869-1	2002	Porphobilinogen synthase (PBGS) catalyzes the condensation of two molecules of 5-aminolevulinic acid (ALA), an essential step in tetrapyrrole biosynthesis.	Tetrapyrroles	129-141	aminolevulinate dehydratase	Homo sapiens	26-30	
10666591-1	2000	The porphobilinogen synthase (PBGS) family of enzymes catalyzes the first common step in the biosynthesis of the essential tetrapyrroles such as chlorophyll and porphyrin.	Tetrapyrroles	123-136	aminolevulinate dehydratase	Homo sapiens	4-28	
10666591-1	2000	The porphobilinogen synthase (PBGS) family of enzymes catalyzes the first common step in the biosynthesis of the essential tetrapyrroles such as chlorophyll and porphyrin.	Tetrapyrroles	123-136	aminolevulinate dehydratase	Homo sapiens	30-34	
10356331-1	1999	Common to the biosynthesis of all known tetrapyrroles is the condensation of two molecules of 5-aminolevulinic acid to the pyrrole porphobilinogen catalyzed by the enzyme porphobilinogen synthase (PBGS).	Tetrapyrroles	40-53	aminolevulinate dehydratase	Homo sapiens	171-195	
10644722-1	2000	Porphobilinogen synthase (PBGS) is an ancient enzyme essential to tetrapyrrole biosynthesis (e.g. heme, chlorophyll, and vitamin B(12)).	Tetrapyrroles	66-78	aminolevulinate dehydratase	Homo sapiens	0-24	
10644722-1	2000	Porphobilinogen synthase (PBGS) is an ancient enzyme essential to tetrapyrrole biosynthesis (e.g. heme, chlorophyll, and vitamin B(12)).	Tetrapyrroles	66-78	aminolevulinate dehydratase	Homo sapiens	26-30	
10356331-1	1999	Common to the biosynthesis of all known tetrapyrroles is the condensation of two molecules of 5-aminolevulinic acid to the pyrrole porphobilinogen catalyzed by the enzyme porphobilinogen synthase (PBGS).	Tetrapyrroles	40-53	aminolevulinate dehydratase	Homo sapiens	197-201	
34994280-1	2022	The delta-aminolevulinic acid dehydratase (ALAD) enzyme is an intermediate in the biosynthetic pathway of tetrapyrroles.	Tetrapyrroles	106-119	aminolevulinate dehydratase	Homo sapiens	4-41	
7592604-1	1995	Porphobilinogen synthase (PBGS) is a metalloenzyme that catalyzes the first common step of tetrapyrrole biosynthesis, the asymmetric condensation of two molecules of 5-aminolevulinic acid (ALA) to form porphobilinogen.	Tetrapyrroles	91-103	aminolevulinate dehydratase	Homo sapiens	26-30	
34994280-1	2022	The delta-aminolevulinic acid dehydratase (ALAD) enzyme is an intermediate in the biosynthetic pathway of tetrapyrroles.	Tetrapyrroles	106-119	aminolevulinate dehydratase	Homo sapiens	43-47	
27551436-8	2016	Gene expression arrays revealed that the expression of three tetrapyrrole biosynthesis enzymes, ALAD, ALAS and PBGD, was impaired upon Albino RNA interference.	Tetrapyrroles	61-73	aminolevulinate dehydratase	Homo sapiens	96-100	
31245736-1	2018	delta-aminolevulinic acid dehydratase (ALAD) is an important enzyme in tetrapyrrole synthesis.	Tetrapyrroles	71-83	aminolevulinate dehydratase	Homo sapiens	0-37	
31245736-1	2018	delta-aminolevulinic acid dehydratase (ALAD) is an important enzyme in tetrapyrrole synthesis.	Tetrapyrroles	71-83	aminolevulinate dehydratase	Homo sapiens	39-43	
27783504-1	2016	Porphobilinogen synthase (PBGS), also known as 5-aminolevulinate dehydratase, is an essential enzyme in the biosynthesis of all tetrapyrroles, which function in respiration, photosynthesis, and methanogenesis.	Tetrapyrroles	128-141	aminolevulinate dehydratase	Homo sapiens	0-24	
27783504-1	2016	Porphobilinogen synthase (PBGS), also known as 5-aminolevulinate dehydratase, is an essential enzyme in the biosynthesis of all tetrapyrroles, which function in respiration, photosynthesis, and methanogenesis.	Tetrapyrroles	128-141	aminolevulinate dehydratase	Homo sapiens	26-30	
19812033-1	2009	Porphobilinogen synthase (PBGS) catalyzes the first common step in tetrapyrrole (e.g. heme, chlorophyll) biosynthesis.	Tetrapyrroles	67-79	aminolevulinate dehydratase	Homo sapiens	0-24	
19812033-1	2009	Porphobilinogen synthase (PBGS) catalyzes the first common step in tetrapyrrole (e.g. heme, chlorophyll) biosynthesis.	Tetrapyrroles	67-79	aminolevulinate dehydratase	Homo sapiens	26-30