PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 26677104-0 2016 Chelidonine induces mitotic slippage and apoptotic-like death in SGC-7901 human gastric carcinoma cells. chelidonine 0-11 sarcoglycan beta Homo sapiens 65-68 26677104-1 2016 The aim of the present study was to investigate the effect of chelidonine on mitotic slippage and apoptotic-like death in SGC-7901 human gastric cancer cells. chelidonine 62-73 sarcoglycan beta Homo sapiens 122-125 26677104-3 2016 Following treatment with chelidonine (10 micromol/l), the ultrastructure changes in SGC-7901, MCF-7 and HepG2 cells were observed by transmission electron microscopy. chelidonine 25-36 sarcoglycan beta Homo sapiens 84-87 26677104-4 2016 The effects of chelidonine on G2/M phase arrest and apoptosis of SGC-7901 cells were determined by flow cytometry. chelidonine 15-26 sarcoglycan beta Homo sapiens 65-68 26677104-7 2016 The phosphorylation of histone H3 at Ser10 was significantly increased following treatment with chelidonine for 24 h, indicating that chelidonine arrested the SGC-7901 cells in the M phase. chelidonine 96-107 sarcoglycan beta Homo sapiens 159-162 26677104-7 2016 The phosphorylation of histone H3 at Ser10 was significantly increased following treatment with chelidonine for 24 h, indicating that chelidonine arrested the SGC-7901 cells in the M phase. chelidonine 134-145 sarcoglycan beta Homo sapiens 159-162 26677104-11 2016 In addition, apoptotic morphological changes in multinucleated cells were observed, the apoptosis rates increased gradually with administration of chelidonine in a time-dependent manner and the protein levels of caspase-3 increased significantly between 24 and 72 h. Thus, chelidonine induces mitotic slippage, and apoptotic-like death occurs in SGC-7901 cells undergoing mitotic catastrophe. chelidonine 273-284 sarcoglycan beta Homo sapiens 346-349 26677104-13 2016 The present study demonstrated that chelidonine induces M phase arrest and mitotic slippage of SGC-7901 human gastric carcinoma cells via downregulating the expression of BubR1, Cdk1 and cyclin B1 proteins. chelidonine 36-47 sarcoglycan beta Homo sapiens 95-98 26677104-16 2016 The current study proposes that chelidonine induces mitotic slippage and apoptotic-like death of SGC-7901 cells. chelidonine 32-43 sarcoglycan beta Homo sapiens 97-100