PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 26481537-0 2015 Chelidonine, a principal isoquinoline alkaloid of Chelidonium majus, attenuates eosinophilic airway inflammation by suppressing IL-4 and eotaxin-2 expression in asthmatic mice. chelidonine 0-11 chemokine (C-C motif) ligand 24 Mus musculus 137-146 26481537-4 2015 METHODS: The mice were sensitized to ovalbumin followed by aerosol allergen challenges and determination of chelidonine"s effect on enhanced pause (Penh), pulmonary eosinophilic infiltration, eotaxin-2, interleukin-4 (IL-4), IL-13, OVA-specific IgE production, and several transcription factors. chelidonine 108-119 chemokine (C-C motif) ligand 24 Mus musculus 192-201 26481537-5 2015 RESULT: Chelidonine strongly suppressed airway eosinophilia, expression of eotaxin-2, IL-4, and IL-13 cytokine production in bronchoalveolar lavage fluid (BALF). chelidonine 8-19 chemokine (C-C motif) ligand 24 Mus musculus 75-84 26481537-8 2015 CONCLUSIONS: Chelidonine has profound inhibitory effects on airway inflammation and this effect is caused by suppression of IL-4, eotaxin-2, and OVA-specific IgE production through the STAT6 and Foxp3 pathways. chelidonine 13-24 chemokine (C-C motif) ligand 24 Mus musculus 130-139