PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 15766244-4 2005 In this study, different attachment points of the TFO to CPT (including positions 7, 9, 10, and 12) were investigated and our findings confirmed and extended previous conclusions. tfo 50-53 choline phosphotransferase 1 Homo sapiens 57-60 15766244-7 2005 Finally, certain TFO-CPT conjugates were able to induce sequence-specific DNA cleavage with the topo I mutants R364H and N722S that are resistant to camptothecin. tfo 17-20 choline phosphotransferase 1 Homo sapiens 21-24 15766244-8 2005 The TFO-CPT conjugates are thus valuable tools to study the interactions involved in the formation of the ternary complex and also to enlarge the family of compounds that poison topo I. tfo 4-7 choline phosphotransferase 1 Homo sapiens 8-11 15766244-9 2005 The fact that an inactive CPT analogue can act as a topo I poison when appropriately coupled to a TFO provides a new perspective at the level of drug design. tfo 98-101 choline phosphotransferase 1 Homo sapiens 26-29