PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 15788899-9 2005 Both PNAs and TFOs were effective at binding the target sequence in naked genomic DNA, but only the TFO-alkylator (TFO2) and the more cationic PNA (PNA2) were detected at the endogenous HER-2/neu promoter in permeabilized cells. tfo 14-17 erb-b2 receptor tyrosine kinase 2 Homo sapiens 186-195 15788899-8 2005 The cpy-bis-PNAs and the TFO-alkylator conjugate prevented HER-2/neu transcription in a reporter gene assay (TFO2 = PNA1 > PNA2 >> TFO1). tfo 25-28 erb-b2 receptor tyrosine kinase 2 Homo sapiens 59-68 15546183-2 2004 To stabilize binding to a polypurine tract in the HER-2/neu promoter, a triplex forming oligonucleotide (TFO) was conjugated to a pyrrolo[1,4]benzodiazepine (PBD), desmethyltomaymycin, and site-specific DNA binding was evaluated. tfo 105-108 erb-b2 receptor tyrosine kinase 2 Homo sapiens 50-59 11691913-3 2001 This study uses a TFO-chlorambucil (chl) conjugate capable of forming site-specific covalent guanine adducts within the HER-2/neu promoter. tfo 18-21 erb-b2 receptor tyrosine kinase 2 Homo sapiens 120-129 34740907-1 2022 Triplex-forming oligonucleotides (TFO) were used to directly target amplified HER2 loci in breast tumors. tfo 34-37 erb-b2 receptor tyrosine kinase 2 Homo sapiens 78-82