PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 23056499-0 2012 AZD1480 blocks growth and tumorigenesis of RET- activated thyroid cancer cell lines. AZD 1480 0-7 ret proto-oncogene Homo sapiens 43-46 23056499-3 2012 Here, we tested the efficacy of a JAK1/2- inhibitor, AZD1480, in the in vitro and in vivo growth of thyroid cancer cell lines expressing oncogenic RET. AZD 1480 53-60 ret proto-oncogene Homo sapiens 147-150 23056499-9 2012 In conclusion, AZD1480 effectively blocks proliferation and tumor growth of activated RET- thyroid cancer cell lines, likely through direct RET inhibition in cancer cells as well as by modulation of the microenvironment (e.g. via JAK/phospho-STAT3 inhibition in endothelial cells). AZD 1480 15-22 ret proto-oncogene Homo sapiens 86-89 23056499-9 2012 In conclusion, AZD1480 effectively blocks proliferation and tumor growth of activated RET- thyroid cancer cell lines, likely through direct RET inhibition in cancer cells as well as by modulation of the microenvironment (e.g. via JAK/phospho-STAT3 inhibition in endothelial cells). AZD 1480 15-22 ret proto-oncogene Homo sapiens 140-143 23056499-10 2012 Thus, AZD1480 should be considered as a therapeutic agent for the treatment of RET- activated thyroid cancers. AZD 1480 6-13 ret proto-oncogene Homo sapiens 79-82 29312610-0 2017 Inhibitor repurposing reveals ALK, LTK, FGFR, RET and TRK kinases as the targets of AZD1480. AZD 1480 84-91 ret proto-oncogene Homo sapiens 46-49 29312610-5 2017 We demonstrate that AZD1480 inhibits ALK, LTK, FGFR1-3, RET and TRKA-C kinases and uncover a physical basis of this specificity. AZD 1480 20-27 ret proto-oncogene Homo sapiens 56-59