PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 32768575-10 2020 Inhibition of the IL-6/JAK/STAT3 pathway with the JAK1/2 specific inhibitor, AZD1480, reversed the associated increase of IL-6. AZD 1480 77-84 signal transducer and activator of transcription 3 Homo sapiens 27-32 19962667-0 2009 The JAK2 inhibitor AZD1480 potently blocks Stat3 signaling and oncogenesis in solid tumors. AZD 1480 19-26 signal transducer and activator of transcription 3 Homo sapiens 43-48 19962667-5 2009 The Jak2 inhibitor AZD1480 suppresses the growth of human solid tumor xenografts harboring persistent Stat3 activity. AZD 1480 19-26 signal transducer and activator of transcription 3 Homo sapiens 102-107 32783069-8 2021 RESULTS: Stimulation with IL-17A induced STAT3 phosphorylation, which was inhibited by the pretreatment with JAK2 inhibitor AZD1480 or JAK1/3 inhibitor tofacitinib. AZD 1480 124-131 signal transducer and activator of transcription 3 Homo sapiens 41-46 25216185-0 2014 AZD1480, a JAK inhibitor, inhibits cell growth and survival of colorectal cancer via modulating the JAK2/STAT3 signaling pathway. AZD 1480 0-7 signal transducer and activator of transcription 3 Homo sapiens 105-110 29722127-8 2018 Application of the JAK2 inhibitor AZD1480 and IL6 neutralizing antibody showed the CD90 and SHH/Gli-regulated liver cancer stem cell functions were mediated by the IL6/JAK2/STAT3 pathway. AZD 1480 34-41 signal transducer and activator of transcription 3 Homo sapiens 173-178 25704089-6 2015 Furthermore, AZD1480 inhibited the expression of phosphorylated-(Tyr-705)-signal transducer and activator of transcription 3 (STAT3) and La in Huh7 cells. AZD 1480 13-20 signal transducer and activator of transcription 3 Homo sapiens 74-124 25704089-6 2015 Furthermore, AZD1480 inhibited the expression of phosphorylated-(Tyr-705)-signal transducer and activator of transcription 3 (STAT3) and La in Huh7 cells. AZD 1480 13-20 signal transducer and activator of transcription 3 Homo sapiens 126-131 24953013-9 2014 The inhibition of JAK2 using JAK2-specific inhibitor AZD1480 or siRNA knockdown, in presence of AURKA overexpression, abrogated the AURKA-mediated STAT3 activation. AZD 1480 53-60 signal transducer and activator of transcription 3 Homo sapiens 147-152 32005799-5 2020 Interruption of IL-6/JAK/STAT3 pathway by a JAK inhibitor AZD1480 reverses the pro-metastatic effect of sevoflurane and the associated increase of both activated STAT3 and infiltrated CD11b+ cells in 4T1 model. AZD 1480 58-65 signal transducer and activator of transcription 3 Homo sapiens 25-30 32005799-5 2020 Interruption of IL-6/JAK/STAT3 pathway by a JAK inhibitor AZD1480 reverses the pro-metastatic effect of sevoflurane and the associated increase of both activated STAT3 and infiltrated CD11b+ cells in 4T1 model. AZD 1480 58-65 signal transducer and activator of transcription 3 Homo sapiens 162-167 30015925-8 2018 The use of the JAK2 inhibitor, AZD-1480, attenuated the suppressive effects of LKB1 overexpression on the growth, metastasis and self-renewal ability of the GBC cells, which further demonstrated that JAK/STAT3 was involved in the LKB1-induced suppression of GBC cell growth, metastasis and self-renewal ability. AZD 1480 31-39 signal transducer and activator of transcription 3 Homo sapiens 204-209 29102603-7 2017 Moreover, the expression levels of p-JAK2 and p-STAT3 were significantly increased in the cortex after SAH induction and were further increased by EPO treatment; in addition, the p-JAK2 inhibitor AZD1480 impaired the protective effect of EPO against SAH-induced EBI in vivo. AZD 1480 196-203 signal transducer and activator of transcription 3 Homo sapiens 48-53 25216185-2 2014 To develop novel therapies for CRC, we have explored the effects of a novel small-molecule JAK inhibitor (AZD1480) on IL-6/JAK/STAT3 pathway and its potential antitumor activity on the human CRC cell lines (HCT116, HT29 and SW480). AZD 1480 106-113 signal transducer and activator of transcription 3 Homo sapiens 127-132 25216185-3 2014 The results showed that, AZD1480 effectively prevents constitutive and IL-6-induced JAK2 and STAT-3 phosphorylation and exerted antitumor functional effects by a decrease in proliferation and an increase in apoptosis in CRC cells. AZD 1480 25-32 signal transducer and activator of transcription 3 Homo sapiens 93-99 24083752-4 2013 After treatment with AZD1480 plus cisplatin, the apoptosis rate increased significantly while the expression level of p-STAT3 protein was decreased. AZD 1480 21-28 signal transducer and activator of transcription 3 Homo sapiens 120-125 24083752-5 2013 CONCLUSION: AZD1480 can inhibit the proliferation, invasion, metastasis and clone formation of SKOV3 cells, induce cellulsar apoptosis, increase the chemotherapeutic sensitivity and reduce the expression level of p-STAT3 protein. AZD 1480 12-19 signal transducer and activator of transcription 3 Homo sapiens 215-220 23013619-4 2012 Administration of the JAK/STAT3 inhibitor AZD1480 alone and in combination with cediranib reduced tumor hypoxia and the infiltration of VEGF inhibitor-induced p-STAT3 macrophages. AZD 1480 42-49 signal transducer and activator of transcription 3 Homo sapiens 26-31 23013619-4 2012 Administration of the JAK/STAT3 inhibitor AZD1480 alone and in combination with cediranib reduced tumor hypoxia and the infiltration of VEGF inhibitor-induced p-STAT3 macrophages. AZD 1480 42-49 signal transducer and activator of transcription 3 Homo sapiens 161-166 23013619-5 2012 Thus, the combination of AZD1480 with cediranib markedly reduced tumor volume, and microvascular density, indicating that up regulation of the STAT3 pathway can mediate resistance to antiangiogenic therapy and combinational approaches may delay or overcome resistance. AZD 1480 25-32 signal transducer and activator of transcription 3 Homo sapiens 143-148 22027691-4 2011 AZD1480 treatment effectively blocks constitutive and stimulus-induced JAK1, JAK2, and STAT-3 phosphorylation in both human and murine glioma cells, and leads to a decrease in cell proliferation and induction of apoptosis. AZD 1480 0-7 signal transducer and activator of transcription 3 Homo sapiens 87-93 23056499-7 2012 However, AZD1480 repressed the growth of STAT3- deficient TPC-1 cells in vitro and in vivo, demonstrating that its effects in this cell line were independent of STAT3 in the tumor cells. AZD 1480 9-16 signal transducer and activator of transcription 3 Homo sapiens 41-46 23056499-9 2012 In conclusion, AZD1480 effectively blocks proliferation and tumor growth of activated RET- thyroid cancer cell lines, likely through direct RET inhibition in cancer cells as well as by modulation of the microenvironment (e.g. via JAK/phospho-STAT3 inhibition in endothelial cells). AZD 1480 15-22 signal transducer and activator of transcription 3 Homo sapiens 242-247 22027691-7 2011 AZD1480 inhibits constitutive and stimulus-induced phosphorylation of JAK2 and STAT-3 in these GBM xenograft tumors in vitro, downstream gene expression, and inhibits cell proliferation. AZD 1480 0-7 signal transducer and activator of transcription 3 Homo sapiens 79-85 22027691-8 2011 Furthermore, AZD1480 suppresses STAT-3 activation in the glioma-initiating cell population in GBM tumors. AZD 1480 13-20 signal transducer and activator of transcription 3 Homo sapiens 32-38 21164517-0 2011 The novel JAK inhibitor AZD1480 blocks STAT3 and FGFR3 signaling, resulting in suppression of human myeloma cell growth and survival. AZD 1480 24-31 signal transducer and activator of transcription 3 Homo sapiens 39-44 21920898-4 2011 In this study, we show that AZD1480 inhibits STAT3 in tumor-associated myeloid cells, reducing their number and inhibiting tumor metastasis. AZD 1480 28-35 signal transducer and activator of transcription 3 Homo sapiens 45-50 21920898-9 2011 Together, our results indicated that AZD1480 can effectively inhibit tumor angiogenesis and metastasis mediated by STAT3 in stromal cells as well as tumor cells. AZD 1480 37-44 signal transducer and activator of transcription 3 Homo sapiens 115-120 21751940-4 2011 We also review the rationale to use novel STAT3 inhibitors and list some of these inhibitors such as STA-21, IS3 295, S3I- M2001 and small molecule JAK2 inhibitors AZD1480 and AZ960 that have been found to be efficient against tumors. AZD 1480 164-171 signal transducer and activator of transcription 3 Homo sapiens 42-47 21164517-4 2011 These biological responses to AZD1480 are associated with concomitant inhibition of phosphorylation of JAK2, STAT3 and MAPK signaling proteins. AZD 1480 30-37 signal transducer and activator of transcription 3 Homo sapiens 109-114 21164517-9 2011 In sum, AZD1480 blocks proliferation, survival, FGFR3 and JAK/STAT3 signaling in myeloma cells cultured alone or cocultured with BM stromal cells, and in vivo. AZD 1480 8-15 signal transducer and activator of transcription 3 Homo sapiens 62-67