PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
27976373-12	2017	As a result of TAM-induced activation of the STAT3 pathway, 5T33MM cells are sensitized to AZD1480 treatment.	AZD 1480	91-98	signal transducer and activator of transcription 3	Mus musculus	45-50	
29228586-7	2017	Hypoxia-induced p-STAT3 increased the mRNA transcription of ICAM-1, which we could inhibit with the STAT3 inhibitor AZD1480.	AZD 1480	116-123	signal transducer and activator of transcription 3	Mus musculus	18-23	
29228586-7	2017	Hypoxia-induced p-STAT3 increased the mRNA transcription of ICAM-1, which we could inhibit with the STAT3 inhibitor AZD1480.	AZD 1480	116-123	signal transducer and activator of transcription 3	Mus musculus	100-105	
25646015-8	2015	AZD1480 treatment inhibited STAT3 phosphorylation and DNA binding, and migration and adhesion of cultured ovarian carcinoma cells and ovarian tumor growth rate, volume, and ascites production in mice.	AZD 1480	0-7	signal transducer and activator of transcription 3	Mus musculus	28-33	
24398427-6	2014	We find that systemic administration of AZD1480 readily replicates this effect, which is associated with reduced Stat3 activation and correlates with diminished tumor cell proliferation and increased apoptosis.	AZD 1480	40-47	signal transducer and activator of transcription 3	Mus musculus	113-118	
25149535-1	2014	AZD1480 is a potent, competitive small-molecule inhibitor of JAK1/2 kinase which inhibits STAT3 phosphorylation and tumor growth.	AZD 1480	0-7	signal transducer and activator of transcription 3	Mus musculus	90-95	
23531921-0	2013	Inhibition of STAT3 with orally active JAK inhibitor, AZD1480, decreases tumor growth in Neuroblastoma and Pediatric Sarcomas In vitro and In vivo.	AZD 1480	54-61	signal transducer and activator of transcription 3	Mus musculus	14-19	
23531921-9	2013	Tumors from AZD1480-treated mice showed inhibition of activated STAT3 as well as decreased expression of STAT3 downstream targets.	AZD 1480	12-19	signal transducer and activator of transcription 3	Mus musculus	64-69	
23531921-9	2013	Tumors from AZD1480-treated mice showed inhibition of activated STAT3 as well as decreased expression of STAT3 downstream targets.	AZD 1480	12-19	signal transducer and activator of transcription 3	Mus musculus	105-110	
23531921-10	2013	Our study provides strong evidence of the anti-tumor growth potency of JAK inhibitor AZD1480 in pediatric solid tumors, providing proof-of principle that inhibition of the JAK/STAT3 signal transduction could be a promising therapeutic target for high-risk pediatric solid tumors.	AZD 1480	85-92	signal transducer and activator of transcription 3	Mus musculus	176-181	
23531921-5	2013	Our data indicate that AZD1480 blocks endogenous as well as IL-6 induced STAT3 activation.	AZD 1480	23-30	signal transducer and activator of transcription 3	Mus musculus	73-78	
23531921-7	2013	AZD1480 induces cell growth inhibition and caspase-dependent apoptosis in vitro and decreases expression of STAT3 target genes, including cell cycle regulators CyclinD1, 3 and CDC25A, anti-apoptotic genes Bcl-2 and survivin, the metastasis-related factor TIMP-1 and c-Myc.	AZD 1480	0-7	signal transducer and activator of transcription 3	Mus musculus	108-113	
22355274-3	2012	AZD1480 is a novel small molecule inhibitor of Jak1/2, which is a key mediator of STAT3 activation.	AZD 1480	0-7	signal transducer and activator of transcription 3	Mus musculus	82-87	
22027691-9	2011	In vivo, AZD1480 inhibits the growth of subcutaneous tumors and increases survival of mice bearing intracranial GBM tumors by inhibiting STAT-3 activity, indicating that pharmacologic inhibition of the JAK/STAT-3 pathway by AZD1480 should be considered for study in the treatment of patients with GBM tumors.	AZD 1480	9-16	signal transducer and activator of transcription 3	Mus musculus	137-143	
22027691-9	2011	In vivo, AZD1480 inhibits the growth of subcutaneous tumors and increases survival of mice bearing intracranial GBM tumors by inhibiting STAT-3 activity, indicating that pharmacologic inhibition of the JAK/STAT-3 pathway by AZD1480 should be considered for study in the treatment of patients with GBM tumors.	AZD 1480	9-16	signal transducer and activator of transcription 3	Mus musculus	206-212	
21164517-8	2011	Importantly, AZD1480 induces cell death of Kms.11 cells grown in the presence of HS-5 bone marrow (BM)-derived stromal cells and inhibits tumor growth in a Kms.11 xenograft mouse model, accompanied with inhibition of phospho-FGFR3, phospho-JAK2, phospho-STAT3 and Cyclin D2 levels.	AZD 1480	13-20	signal transducer and activator of transcription 3	Mus musculus	254-259