PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
33026572-7	2021	We have also found that both Memantine (5 microM) and Ibuprofen (200 muM) significantly prevented the STZ-induced change in CaMKIIalpha, CREB, Calpain, and Caspase 3 expressions in C6 astrocytoma cells.	Memantine	29-38	cAMP responsive element binding protein 1	Rattus norvegicus	137-141	
22442066-10	2012	Blocking NMDARs with memantine (30 mum) or GluN2B-containing receptors with ifenprodil (3 mum) prevents CREB shutoff effectively in CTX and MSNs, and also rescues both neuronal types from NMDA-mediated toxicity.	Memantine	21-30	cAMP responsive element binding protein 1	Rattus norvegicus	104-108	
33290797-0	2021	Memantine treatment exerts an antidepressant-like effect by preventing hippocampal mitochondrial dysfunction and memory impairment via upregulation of CREB/BDNF signaling in the rat model of chronic unpredictable stress-induced depression.	Memantine	0-9	cAMP responsive element binding protein 1	Rattus norvegicus	151-155	
33290797-9	2021	CUS also reduced the expression of cell survival genes, cyclic-AMP response element-binding protein (CREB), and brain-derived nerve growth factor (BDNF), which was reversed by treatment with Memantine.	Memantine	191-200	cAMP responsive element binding protein 1	Rattus norvegicus	56-99	
33290797-9	2021	CUS also reduced the expression of cell survival genes, cyclic-AMP response element-binding protein (CREB), and brain-derived nerve growth factor (BDNF), which was reversed by treatment with Memantine.	Memantine	191-200	cAMP responsive element binding protein 1	Rattus norvegicus	101-105	
33290797-11	2021	Thus, Memantine treatment exerts an antidepressant-like effect by preventing CUS induced excitotoxicity, oxidative stress, and enhancing CUS induced decrease in mitochondrial functioning and expression of cell survival genes via upregulation of stress-responsive CREB/BDNF signaling.	Memantine	6-15	cAMP responsive element binding protein 1	Rattus norvegicus	263-267	
30233298-9	2018	However, the declined cognitive ability were ameliorated by memantine treatment with increased GluN1, GluN2A, GluN2B, BDNF, pCREB/CREB, and pTrkB/TrkB expression in the hippocampus.	Memantine	60-69	cAMP responsive element binding protein 1	Rattus norvegicus	125-129