PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 20060890-0 2010 Simvastatin induces derepression of PTEN expression via NFkappaB to inhibit breast cancer cell growth. Simvastatin 0-11 phosphatase and tensin homolog Homo sapiens 36-40 20060890-10 2010 Importantly, simvastatin markedly prevented binding of NFkappaB to the two canonical recognition elements, NFRE-1 and NFRE-2 present in the PTEN promoter. Simvastatin 13-24 phosphatase and tensin homolog Homo sapiens 140-144 20060890-11 2010 Contrary to the transcriptional suppression of Bcl(XL), simvastatin significantly increased the transcription of PTEN. Simvastatin 56-67 phosphatase and tensin homolog Homo sapiens 113-117 20060890-13 2010 Taken together, our data present a novel bifaceted mechanism where simvastatin acts on a nodal transcription factor NFkappaB, which attenuates the expression of anti-apoptotic Bcl(XL) and simultaneously derepresses the expression of anti-proliferative/proapoptotic tumor suppressor PTEN to prevent breast cancer cell growth. Simvastatin 67-78 phosphatase and tensin homolog Homo sapiens 282-286 15776112-3 2005 Simvastatin, a cholesterol synthesis inhibitor, lowered raft cholesterol content, inhibited Akt1 serine-threonine kinase (protein kinase Balpha)/protein kinase B (Akt/PKB) pathway signaling, and induced apoptosis in caveolin- and PTEN-negative LNCaP PCa cells. Simvastatin 0-11 phosphatase and tensin homolog Homo sapiens 230-234 18065496-4 2008 In our current study, we show that simvastatin, pravastatin and fluvastatin can induce PTEN expression in a dose-dependent manner. Simvastatin 35-46 phosphatase and tensin homolog Homo sapiens 87-91 26565813-5 2016 Simvastatin markedly suppressed PI3K/Akt/mTOR signalling by activating PTEN (p = 0.005) and by dephosphorylating Akt (p = 0.002) and S6RP (p = 0.033); it also inhibited MAPK/ERK pathway by dephosphorylating c-Raf (p = 0.018) and ERK1/2 (p = 0.002). Simvastatin 0-11 phosphatase and tensin homolog Homo sapiens 71-75 29568880-2 2018 simvastatin has been demonstrated to exhibit antitumor effects, and so the aim of the present study was to assess the effects of simvastatin on the growth of human PTEN haploinsufficient lipoma cells. Simvastatin 0-11 phosphatase and tensin homolog Homo sapiens 164-168 29568880-2 2018 simvastatin has been demonstrated to exhibit antitumor effects, and so the aim of the present study was to assess the effects of simvastatin on the growth of human PTEN haploinsufficient lipoma cells. Simvastatin 129-140 phosphatase and tensin homolog Homo sapiens 164-168 29568880-5 2018 Furthermore, it was demonstrated that the expression of cellular PTEN mRNA and protein was increased following simvastatin stimulation. Simvastatin 111-122 phosphatase and tensin homolog Homo sapiens 65-69 29568880-7 2018 It was also demonstrated that simvastatin induced PTEN transcriptional upregulation by increasing peroxisome proliferator-activated receptor (PPAR)gamma expression. Simvastatin 30-41 phosphatase and tensin homolog Homo sapiens 50-54 29568880-8 2018 The small interfering RNA-mediated knockdown of PPARgamma abrogated the stimulatory effect of simvastatin on the PTEN protein, but did not influence apoptosis. Simvastatin 94-105 phosphatase and tensin homolog Homo sapiens 113-117 29568880-9 2018 The results of the present study suggest that simvastatin may be beneficial for patients with inoperable PTEN haploinsufficient lipomas. Simvastatin 46-57 phosphatase and tensin homolog Homo sapiens 105-109 29208461-0 2018 Simvastatin inhibits the development of radioresistant esophageal cancer cells by increasing the radiosensitivity and reversing EMT process via the PTEN-PI3K/AKT pathway. Simvastatin 0-11 phosphatase and tensin homolog Homo sapiens 148-152 29208461-10 2018 Further assay substantiated the PTEN suppression after irradiation, which was elevated following simvastatin pre-treatment. Simvastatin 97-108 phosphatase and tensin homolog Homo sapiens 32-36 29208461-11 2018 Moreover, PTEN cessation attenuated the inhibitory effect of simvastatin on PI3K/AKT activation, and subsequently antagonized simvastatin-induced radiosensitivity and EMT reversion. Simvastatin 61-72 phosphatase and tensin homolog Homo sapiens 10-14 29208461-11 2018 Moreover, PTEN cessation attenuated the inhibitory effect of simvastatin on PI3K/AKT activation, and subsequently antagonized simvastatin-induced radiosensitivity and EMT reversion. Simvastatin 126-137 phosphatase and tensin homolog Homo sapiens 10-14 29208461-13 2018 Together, simvastatin inhibits the development of Ec9706-R cells by increasing radiosensitivity and reversing EMT via PTEN-PI3K/AKT pathway, implying a promising strategy against EC radioresistance. Simvastatin 10-21 phosphatase and tensin homolog Homo sapiens 118-122 33742146-11 2021 Experiments in xenografts and in patients treated with Simvastatin confirm statin-mediated BMP pathway activation, activation of PTEN and downregulation of mTOR signalling. Simvastatin 55-66 phosphatase and tensin homolog Homo sapiens 129-133 29385181-0 2018 Simvastatin and metformin inhibit cell growth in hepatitis C virus infected cells via mTOR increasing PTEN and autophagy. Simvastatin 0-11 phosphatase and tensin homolog Homo sapiens 102-106 26565813-7 2016 Concordantly, simvastatin strongly suppressed PI3K/Akt/mTOR pathway by enhancing PTEN expression and by further sequentially dephosphorylating downstream cascades including Akt, mTOR, p70S6K, S6RP and 4E-BP1. Simvastatin 14-25 phosphatase and tensin homolog Homo sapiens 81-85 24535918-9 2014 Our results provide a molecular basis for the therapeutic application of simvastatin to reduce RhoA/PTEN activation, restore cytosolic levels of phosphorylated p21/p27, and induce angiogenic processes. Simvastatin 73-84 phosphatase and tensin homolog Homo sapiens 100-104 23973711-7 2013 Compared with PTEN wild-type TNBC cells, PTEN mutant-type TNBC cells showed a decreased response to simvastatin. Simvastatin 100-111 phosphatase and tensin homolog Homo sapiens 14-18 23973711-7 2013 Compared with PTEN wild-type TNBC cells, PTEN mutant-type TNBC cells showed a decreased response to simvastatin. Simvastatin 100-111 phosphatase and tensin homolog Homo sapiens 41-45 23973711-9 2013 The TNBC cell lines, which showed increased expression of p-Akt, appeared to attenuate the expression of p-Akt by PTEN loss in simvastatin-treated TNBC cells. Simvastatin 127-138 phosphatase and tensin homolog Homo sapiens 114-118 23973711-10 2013 The Akt inhibitor, LY294002, augmented the effect of simvastatin on PTEN wild-type TNBC cells. Simvastatin 53-64 phosphatase and tensin homolog Homo sapiens 68-72