PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 28839280-5 2017 The objective of this study was to determine if the aqueous extract of HC (HCE) could prevent simvastatin-induced muscle toxicity in rats, and whether HCE could also exert beneficial effects on reducing high-fat diet-induced hypercholesterolemia and elevated liver cholesterol, thereby reducing the dose of simvastatin when used in combined therapy. Simvastatin 94-105 RNA guanylyltransferase and 5'-phosphatase Mus musculus 75-78 28839280-6 2017 From our results, HCE significantly restored simvastatin-induced reduction in muscle weights and reduced elevated plasma creatine kinase in rats. Simvastatin 45-56 RNA guanylyltransferase and 5'-phosphatase Mus musculus 18-21 28839280-7 2017 HCE also improved simvastatin-induced reduction in muscle glutathione levels, muscle mitochondrial membrane potential, and reduced simvastatin-induced muscle inflammation. Simvastatin 18-29 RNA guanylyltransferase and 5'-phosphatase Mus musculus 0-3 28839280-7 2017 HCE also improved simvastatin-induced reduction in muscle glutathione levels, muscle mitochondrial membrane potential, and reduced simvastatin-induced muscle inflammation. Simvastatin 131-142 RNA guanylyltransferase and 5'-phosphatase Mus musculus 0-3 28839280-9 2017 In conclusion, our study provided in vivo evidence that HCE has potential protective effect on simvastatin-induced toxicity in muscles, and also beneficial effects on diet-induced non-alcoholic fatty liver and hyperlipidemia when being used alone or in combination with simvastatin at a reduced dose. Simvastatin 95-106 RNA guanylyltransferase and 5'-phosphatase Mus musculus 56-59 28839280-9 2017 In conclusion, our study provided in vivo evidence that HCE has potential protective effect on simvastatin-induced toxicity in muscles, and also beneficial effects on diet-induced non-alcoholic fatty liver and hyperlipidemia when being used alone or in combination with simvastatin at a reduced dose. Simvastatin 270-281 RNA guanylyltransferase and 5'-phosphatase Mus musculus 56-59