PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 19505368-0 2009 Hypercholesterolaemia induces early renal lesions characterized by upregulation of MMP-9 and iNOS and ET(A)R: alleviated by a dual endothelin receptor antagonist CPU0213 and simvastatin. Simvastatin 174-185 nitric oxide synthase 2 Rattus norvegicus 93-97 20452610-13 2011 Simvastatin treatment caused a decrease in epithelial iNOS levels, while MPO levels were not modulated. Simvastatin 0-11 nitric oxide synthase 2 Rattus norvegicus 54-58 22130356-9 2012 In addition, simvastatin raised nitric oxide synthase (NOS) activity and eNOS expression at basal condition; inhibited NOS activity and iNOS expression when treated with H(2)O(2). Simvastatin 13-24 nitric oxide synthase 2 Rattus norvegicus 136-140 22022327-8 2011 On day 5, gene expressions of ET-1, ERA, NOS2, NOS3, MMP and TIMP significantly decreased in the simvastatin group. Simvastatin 97-108 nitric oxide synthase 2 Rattus norvegicus 41-45 19100117-7 2008 The myocardial activities of iNOS and MPO, the contents of NO and MDA were significantly lower while eNOS activity was significantly higher in I/R plus sim group than those in I/R group (5.02 +/- 1.64 vs. 9.19 +/- 2.89, 586.21 +/- 126.97 vs. 744.49 +/- 137.53, 257.72 +/- 93.43 vs. 384.10 +/- 40.68, 72.10 +/- 18.56 vs. 111.84 +/- 38.58, 7.08 +/- 1.74 vs. 3.72 +/- 0.98, all P < 0.05). Simvastatin 152-155 nitric oxide synthase 2 Rattus norvegicus 29-33 15705589-0 2005 Simvastatin attenuates expression of cytokine-inducible nitric-oxide synthase in embryonic cardiac myoblasts. Simvastatin 0-11 nitric oxide synthase 2 Rattus norvegicus 46-77 18047562-4 2008 We evaluated TH positive neurons, astroglial, and microglial populations and found that simvastatin prevented the inflammatory processes, as the induction of interleukin-1beta, tumor necrosis factor-alpha, and iNOS and the consequent dopaminergic degeneration induced by LPS. Simvastatin 88-99 nitric oxide synthase 2 Rattus norvegicus 210-214 18619353-7 2008 RESULT: Data of the study demonstrated that compared with model group, the activity of NOS and the gene expression of eNOS were increased remarkably, and however the gene expression of iNOS was reduced markedly in simvastatin group and TSG 60, 120 mg x kg(-1) x d(-1) group. Simvastatin 214-225 nitric oxide synthase 2 Rattus norvegicus 185-189 15705589-3 2005 In this study, we examined the impact of inhibition of hydroxymethylglutaryl coenzyme A (HMG-CoA) reductase with simvastatin on the expression of inducible nitric-oxide synthase (iNOS) in embryonic cardiac myoblasts stimulated with the proinflammatory cytokines, interleukin-1 or tumor necrosis factor. Simvastatin 113-124 nitric oxide synthase 2 Rattus norvegicus 146-177 15705589-3 2005 In this study, we examined the impact of inhibition of hydroxymethylglutaryl coenzyme A (HMG-CoA) reductase with simvastatin on the expression of inducible nitric-oxide synthase (iNOS) in embryonic cardiac myoblasts stimulated with the proinflammatory cytokines, interleukin-1 or tumor necrosis factor. Simvastatin 113-124 nitric oxide synthase 2 Rattus norvegicus 179-183 15705589-4 2005 Treatment with simvastatin significantly reduced the levels of iNOS mRNA and protein in cytokine-treated rat H9c2 cardiac embryonic myoblasts. Simvastatin 15-26 nitric oxide synthase 2 Rattus norvegicus 63-67 15705589-8 2005 Hence, treatment with simvastatin can attenuate iNOS expression and NO synthesis in cytokine-stimulated embryonic cardiac myoblasts. Simvastatin 22-33 nitric oxide synthase 2 Rattus norvegicus 48-52 34147541-9 2021 Simvastatin increased levels of circulating EPCs and decreased iNOS, MMP-2, MMP-9 and VEGF mRNA levels, while increased eNOS mRNA in aneurysmal tissue. Simvastatin 0-11 nitric oxide synthase 2 Rattus norvegicus 63-67 11470468-7 2001 Simvastatin also significantly decreased iNOS mRNA and protein, as well as nitrite production after ischemia-reperfusion. Simvastatin 0-11 nitric oxide synthase 2 Rattus norvegicus 41-45 32945441-0 2020 Effects of simvastatin on iNOS and caspase-3 levels and oxidative stress following smoke inhalation injury. Simvastatin 11-22 nitric oxide synthase 2 Rattus norvegicus 26-30 32945441-12 2020 In rats with smoke inhalation injury, simvastatin inhibited iNOS and caspase-3 expression in lung tissues and mitigated oxidative stress, thereby exerting a protective effect. Simvastatin 38-49 nitric oxide synthase 2 Rattus norvegicus 60-64 28915536-11 2017 Losartan with simvastatin produced similar effects on renal tissues oxidative stress, nitrite and inflammatory markers levels and on protein expressions of eNOS, iNOS, TNF-alpha, IL-6 and IL-1beta. Simvastatin 14-25 nitric oxide synthase 2 Rattus norvegicus 162-166 27665951-0 2017 Inhibition of inducible nitric oxide synthase (iNOS) by simvastatin attenuates cardiac hypertrophy in rats. Simvastatin 56-67 nitric oxide synthase 2 Rattus norvegicus 14-45 27665951-0 2017 Inhibition of inducible nitric oxide synthase (iNOS) by simvastatin attenuates cardiac hypertrophy in rats. Simvastatin 56-67 nitric oxide synthase 2 Rattus norvegicus 47-51 26823851-3 2015 The aim of the present study was to investigate the effects of simvastatin on iNOS expression based on a lipopolysaccharide (LPS)-induced septic rat model. Simvastatin 63-74 nitric oxide synthase 2 Rattus norvegicus 78-82 26000813-0 2016 Effects of simvastatin on the expression of inducible nitric oxide synthase and brain-derived neurotrophic factor in a lipopolysaccharide-induced rat model of Parkinson disease. Simvastatin 11-22 nitric oxide synthase 2 Rattus norvegicus 44-75 26000813-1 2016 OBJECTIVE: To investigate the effects of simvastatin on the expression of inducible nitric oxide synthase (iNOS) and brain-derived neurotrophic factor (BDNF) in the substantia nigra in a lipopolysaccharide (LPS)-induced rat model of Parkinson disease (PD), and to study the mechanisms underlying the neuroprotective effects of simvastatin in PD. Simvastatin 41-52 nitric oxide synthase 2 Rattus norvegicus 74-105 26000813-1 2016 OBJECTIVE: To investigate the effects of simvastatin on the expression of inducible nitric oxide synthase (iNOS) and brain-derived neurotrophic factor (BDNF) in the substantia nigra in a lipopolysaccharide (LPS)-induced rat model of Parkinson disease (PD), and to study the mechanisms underlying the neuroprotective effects of simvastatin in PD. Simvastatin 41-52 nitric oxide synthase 2 Rattus norvegicus 107-111 26535078-7 2015 Treatment of simvastatin reduced the LPS-accelerated infarct size by 73%, and decreased the ischemia/reperfusion-induced expressions of pro-inflammatory mediators such as iNOS, COX-2 and IL-1beta in LPS-injected rat brains. Simvastatin 13-24 nitric oxide synthase 2 Rattus norvegicus 171-175 26823851-9 2015 RESULTS: Compared with the septic group, significant decreases in the oxygenation index and expression level of iNOS were observed in the simvastatin group. Simvastatin 138-149 nitric oxide synthase 2 Rattus norvegicus 112-116 26823851-10 2015 Furthermore, simvastatin treatment resulted in a significant decrease in iNOS levels and the pathological integral of lung injury score in septic rats. Simvastatin 13-24 nitric oxide synthase 2 Rattus norvegicus 73-77 26823851-12 2015 Decreasing iNOS levels may contribute to the protective role of simvastatin in lung injury. Simvastatin 64-75 nitric oxide synthase 2 Rattus norvegicus 11-15 24098525-8 2013 Compared with model rats in 24(th) week group, rats in simvastatin group had less expressions of iNOS, alpha-SMA, and Collagen I and more expressions of eNOS. Simvastatin 55-66 nitric oxide synthase 2 Rattus norvegicus 97-101 25153633-7 2014 Furthermore, the increased expression of atrial iNOS, INCX and Rac1 activity were significantly decreased by the simvastatin. Simvastatin 113-124 nitric oxide synthase 2 Rattus norvegicus 48-52 32288932-6 2014 Simvastatin inhibited LPS-induced TLR4 expression at the mRNA and protein levels in a time-dependent manner (p<0.01), and alleviated inflammation in RPMVECs by inhibiting the release of inflammatory factors such as TNF-alpha and iNOS. Simvastatin 0-11 nitric oxide synthase 2 Rattus norvegicus 229-233 24098525-11 2013 CONCLUSIONS: Simvastatin improves the prognosis of NASH-related fibrosis by increasing the expression of eNOS, decreasing the expression of iNOS, and inhibiting the activation of HSC. Simvastatin 13-24 nitric oxide synthase 2 Rattus norvegicus 140-144 23181416-11 2013 Simvastatin reduced expression of iNOS, MMP-1 and -8, RANK, and RANKL and increased BMP-2 and OPG levels in the periodontal tissue. Simvastatin 0-11 nitric oxide synthase 2 Rattus norvegicus 34-38