PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
33330868-0	2021	Binding of SARS-CoV-2 spike protein to ACE2 is disabled by thiol-based drugs; evidence from in vitro SARS-CoV-2 infection studies.	Sulfhydryl Compounds	59-64	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	22-27	
33330868-4	2021	We found that thiol-based drugs, cysteamine and WR-1065 (the active metabolite of amifostine) in particular, decrease binding of SARS-CoV-2 spike protein to its receptor, decrease the entry efficiency of SARS-CoV-2 spike pseudotyped virus, and inhibit SARS-CoV-2 live virus infection.	Sulfhydryl Compounds	14-19	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	140-145	
33330868-4	2021	We found that thiol-based drugs, cysteamine and WR-1065 (the active metabolite of amifostine) in particular, decrease binding of SARS-CoV-2 spike protein to its receptor, decrease the entry efficiency of SARS-CoV-2 spike pseudotyped virus, and inhibit SARS-CoV-2 live virus infection.	Sulfhydryl Compounds	14-19	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	215-220	
33330868-6	2021	One Sentence Summary: Thiol-based drugs decrease binding of SARS-CoV-2 spike protein to its receptor and inhibit SARS-CoV-2 cell entry.	Sulfhydryl Compounds	22-27	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	71-76	
34558135-2	2021	The interaction between the SARS-CoV-2 spike protein and the human receptor angiotensin-converting enzyme 2, both of which contain several cysteine residues, is impacted by the disulfide-thiol balance in the host cell.	Sulfhydryl Compounds	187-192	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	39-44	
32656452-6	2020	In this study, the role of thiol-disulfide balance on the interactions between SARS-CoV/CoV-2 spike proteins and ACE2 was investigated using molecular dynamics simulations.	Sulfhydryl Compounds	27-32	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	94-99	
32656452-7	2020	The study revealed that the binding affinity was significantly impaired when all of the disulfide bonds of both ACE2 and SARS-CoV/CoV-2 spike proteins were reduced to thiol groups.	Sulfhydryl Compounds	167-172	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	136-141	
35123263-0	2022	The function of SARS-CoV-2 spike protein is impaired by disulfide-bond disruption with mutation at cysteine-488 and by thiol-reactive N-acetyl-cysteine and glutathione.	Sulfhydryl Compounds	119-124	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	27-32	
35123263-5	2022	Consistently, in vitro binding of RBD and ACE2, spike-mediated cell-cell fusion, and pseudotyped viral infection of VeroE6/TMPRSS2 cells were inhibited by the thiol-reactive compounds N-acetylcysteine (NAC) and a reduced form of glutathione (GSH).	Sulfhydryl Compounds	159-164	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	48-53