PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
22014003-4	2012	Among the 62 hits of a screen of ~15 000 thiol-containing fragments, a naphthyl-thiazole-containing molecule was identified that selectively inhibited and labeled the allosteric cysteine in the p10 subunit of caspase-5, but caused very little inhibition or labeling of caspase-1.	Sulfhydryl Compounds	41-46	caspase 1	Homo sapiens	269-278	
16682620-2	2006	Highly specific thiol-containing inhibitors of the human inflammatory caspase-1 were identified by using disulfide trapping, a method for site-directed small-molecule discovery.	Sulfhydryl Compounds	16-21	caspase 1	Homo sapiens	70-79	
17314138-5	2007	These were mainly due to the peculiar Tellur(IV)-thiol chemistry of the compound, which enabled the compound to interact with cysteine residues on both inflammatory and apoptotic caspases, resulting in their inactivation.	Sulfhydryl Compounds	49-54	caspase 1	Homo sapiens	179-187	
16984172-4	2006	This new approach resulted in potent, reversible, competitive inhibitors of caspase-1 (IC50 < 10 nM), with significant advantages over aldehydes such as high stability in vitro to thiols (10 mM dithiothreitol (pH 7.2), 20 mM glutathione (pH 7.2, 9, 11)) and aqueous media, as well as some highly desirable druglike features.	Sulfhydryl Compounds	183-189	caspase 1	Homo sapiens	76-85	
9437520-10	1997	In conclusion, our study shows that caspases are quite sensitive to thiol oxidation and that DSF is a very potent oxidant of caspase protein thiol(s), being 700-fold more potent than glutathione disulfide.	Sulfhydryl Compounds	68-73	caspase 1	Homo sapiens	36-44	
12527914-0	2003	Thiol alkylation inhibits the mitogenic effects of platelet-derived growth factor and renders it proapoptotic via activation of STATs and p53 and induction of expression of caspase1 and p21(waf1/cip1).	Sulfhydryl Compounds	0-5	caspase 1	Homo sapiens	173-181	
12527914-7	2003	The inhibition of AP-1 and activation of STATs, particularly STAT1, by thiol alkylation correlated with increased production of active caspase 1 and apoptosis in VSMC.	Sulfhydryl Compounds	71-76	caspase 1	Homo sapiens	135-144	
9437520-10	1997	In conclusion, our study shows that caspases are quite sensitive to thiol oxidation and that DSF is a very potent oxidant of caspase protein thiol(s), being 700-fold more potent than glutathione disulfide.	Sulfhydryl Compounds	68-73	caspase 1	Homo sapiens	36-43