PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 29955703-13 2017 GEN and flavone antagonists of AhR may be useful for reactivation of BRCA1 and ERalpha via CpG demethylation in ERalpha-negative breast cancer cells harboring constitutively active AhR. flavone 8-15 estrogen receptor 1 Homo sapiens 79-86 29955703-13 2017 GEN and flavone antagonists of AhR may be useful for reactivation of BRCA1 and ERalpha via CpG demethylation in ERalpha-negative breast cancer cells harboring constitutively active AhR. flavone 8-15 estrogen receptor 1 Homo sapiens 112-119 22634477-5 2012 In MCF-7 breast carcinoma cells chalcone and flavone suppress ERalpha activity through stimulation of the stress-activated members of the mitogen-activated protein kinase (MAPK) family: c-Jun N-terminal kinase (JNK)1 and JNK2. flavone 45-52 estrogen receptor 1 Homo sapiens 62-69 17379515-0 2007 Synthesis, characterization, and estrogen receptor binding affinity of flavone-, indole-, and furan-estradiol conjugates. flavone 71-78 estrogen receptor 1 Homo sapiens 33-50 17379515-3 2007 In vitro competitive binding assays for the estrogen receptor (alpha-ER), using [(3)H]estradiol (RBA=100) as a competitor, revealed that a two-carbon alkyl linker combined with a flavone conjugate provided the highest binding affinity (RBA approximately 9), warranting further studies on their potential use as selective estrogen-receptor modulators (SERMs) for hormone-replacement therapies. flavone 179-186 estrogen receptor 1 Homo sapiens 44-61