PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 30819233-7 2019 In gene expression analysis, CCND1-amplified luminal A tumours showed increased proliferation (P < 0.001) and decreased progesterone (P = 0.002) levels along with a large overlap in differentially expressed genes when comparing luminal A and B-amplified vs. non-amplified tumours. Progesterone 123-135 cyclin D1 Homo sapiens 29-34 12941814-12 2003 In addition, activation of a common tumor-derived AR allele by 17 beta-estradiol and progesterone was inhibited through ectopic expression of cyclin D1. Progesterone 85-97 cyclin D1 Homo sapiens 142-151 33728745-5 2021 Here, we investigated the effects of o,p"-DDT, p,p"-DDT, and endosulfan and of hormones estradiol, testosterone, and progesterone on the expression of estrogen, progesterone, and androgen receptors (ER, PR, and AR) and of their target genes (KLF4, VEGFA, CCND1, PRLR, CDKN1A, and BCL6) in MCF-7 and MDA-MB-231 cells. Progesterone 117-129 cyclin D1 Homo sapiens 255-260 25791399-5 2015 RESULTS: CCND1, c-Fos and c-Jun mRNA levels were all significantly increased by treatment with progesterone in QGP-1 cells with PRB expression compared with PRA-transfected cells (p = 0.02, p = 0.007 and p = 0.001, respectively). Progesterone 95-107 cyclin D1 Homo sapiens 9-14 25791399-8 2015 CONCLUSION: The results of the present study demonstrate that PRA could play an inhibitory role in the cell proliferation of PNETs, possibly by inhibiting PRB-mediated signals in the presence of progesterone, which could result in decreased CCND1 expression. Progesterone 195-207 cyclin D1 Homo sapiens 241-246 17138644-5 2007 Progestin induction of the cyclin D1 gene, which lacks a progesterone response element, was dependent on PR activation of the Src/MAPK pathway, whereas induction of the Sgk (serum and glucocorticoid regulated kinase) gene that contains a functional progesterone response element was unaffected by mutations that interfere with PR activation of Src. Progesterone 57-69 cyclin D1 Homo sapiens 27-36 15845746-0 2005 Progesterone inhibits the estrogen-induced phosphoinositide 3-kinase-->AKT-->GSK-3beta-->cyclin D1-->pRB pathway to block uterine epithelial cell proliferation. Progesterone 0-12 cyclin D1 Homo sapiens 98-107