PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
8462454-1	1993	We have investigated the mechanisms by which insulin and insulin-like growth factor-I (IGF-I) regulate the synthesis of progesterone by swine ovary granulosa cells.	Progesterone	120-132	insulin	Sus scrofa	45-52	
8462454-2	1993	Analysis of the cell density dependence of the effects of insulin and IGF-I showed that the induction of progesterone synthesis by these growth factors is consistent with an autocrine or paracrine model of action, which involves the insulin- and IGF-I-stimulated release of a soluble factor(s) into the culture medium.	Progesterone	105-117	insulin	Sus scrofa	58-65	
8462454-2	1993	Analysis of the cell density dependence of the effects of insulin and IGF-I showed that the induction of progesterone synthesis by these growth factors is consistent with an autocrine or paracrine model of action, which involves the insulin- and IGF-I-stimulated release of a soluble factor(s) into the culture medium.	Progesterone	105-117	insulin	Sus scrofa	233-240	
8462454-6	1993	Pertussis toxin treatment, shown to inhibit the generation of inositol phosphoglycans in other systems, was found to inhibit the effects of insulin on progesterone synthesis in granulosa cells.	Progesterone	151-163	insulin	Sus scrofa	140-147	
8462454-7	1993	Finally, the stimulatory effects of insulin and IGF-I on progesterone synthesis by intact granulosa cells were markedly inhibited by the addition of antiinositol phosphoglycan antibodies to the culture medium.	Progesterone	57-69	insulin	Sus scrofa	36-43	
8462454-8	1993	Based on these observations, we propose that the release of inositol phosphoglycans into the extracellular medium plays an important role in the signaling mechanisms by which insulin and IGF-I regulate the synthesis of progesterone in swine ovary granulosa cells.	Progesterone	219-231	insulin	Sus scrofa	175-182	
1649742-6	1991	At the latter time, TNF alpha significantly suppressed insulin- and insulin- plus FSH-stimulated progesterone accumulation, with respective ID50 values of 0.08 +/- 0.008 and 0.06 +/- 0.014 nM, but did not affect basal progesterone accumulation or DNA content.	Progesterone	97-109	insulin	Sus scrofa	55-75	
1649742-14	1991	Granulosa cells are susceptible to the inhibitory actions of TNF alpha on FSH- and insulin-supported progesterone biosynthesis and cAMP accumulation.	Progesterone	101-113	insulin	Sus scrofa	83-90	
3516657-1	1986	Insulin synergistically amplified the stimulatory effect of low density lipoprotein (LDL) on progesterone biosynthesis by primary cultures of swine granulosa cells.	Progesterone	93-105	insulin	Sus scrofa	0-7	
3516657-3	1986	We conclude that insulin and LDL synergistically enhance progesterone biosynthesis by swine granulosa cells via specific mechanisms that depend upon 1,2,-cyclohexanedione-sensitive residues within LDL apoprotein.	Progesterone	57-69	insulin	Sus scrofa	17-24	
24790602-5	2014	The gonadotrophin/insulin-induced release of progesterone from granulosa and theca interna cells and the release of oestradiol and androstenedione from theca cells was also modified by adiponectin.	Progesterone	45-57	insulin	Sus scrofa	18-25	
3917908-1	1985	To characterize the nature of insulin action on ovarian cells, an in vitro system of swine granulosa cells was developed in which 3- to 50-fold stimulation of progesterone production was observed in response to insulin under serum-free or sparsely (1%) serum-supplemented conditions.	Progesterone	159-171	insulin	Sus scrofa	30-37	
3917908-1	1985	To characterize the nature of insulin action on ovarian cells, an in vitro system of swine granulosa cells was developed in which 3- to 50-fold stimulation of progesterone production was observed in response to insulin under serum-free or sparsely (1%) serum-supplemented conditions.	Progesterone	159-171	insulin	Sus scrofa	211-218	
3917908-4	1985	The mechanisms subserving insulin action were explored further by testing the capacity of insulin to 1) increase progesterone accumulation in response to exogenously provided pregnenolone, and 2) stimulate pregnenolone biosynthesis in the presence of trilostane, an inhibitor of pregnenolone metabolism.	Progesterone	113-125	insulin	Sus scrofa	26-33	
3917908-4	1985	The mechanisms subserving insulin action were explored further by testing the capacity of insulin to 1) increase progesterone accumulation in response to exogenously provided pregnenolone, and 2) stimulate pregnenolone biosynthesis in the presence of trilostane, an inhibitor of pregnenolone metabolism.	Progesterone	113-125	insulin	Sus scrofa	90-97	
3917908-5	1985	The effects of insulin were to increase the biosynthesis of progesterone from available pregnenolone and increase the production of pregnenolone from endogenous sterol substrate.	Progesterone	60-72	insulin	Sus scrofa	15-22	
3917908-9	1985	Moreover, our studies indicate that insulin exerts significant actions at several levels of progestin biosynthesis, including the production of pregnenolone, progesterone, and 20 alpha-dihydroprogesterone by granulosa cells.	Progesterone	158-170	insulin	Sus scrofa	36-43	
6370258-2	1984	Insulin-receptor antiserum but not control serum significantly (greater than 85%) attenuated insulin"s stimulation of progesterone biosynthesis.	Progesterone	118-130	insulin	Sus scrofa	0-7	
6370258-2	1984	Insulin-receptor antiserum but not control serum significantly (greater than 85%) attenuated insulin"s stimulation of progesterone biosynthesis.	Progesterone	118-130	insulin	Sus scrofa	93-100	
6193139-4	1983	Purified porcine insulin significantly augmented the biosynthesis and secretion of progesterone by cultured granulosa cells.	Progesterone	83-95	insulin	Sus scrofa	17-24	
6193139-6	1983	Under serum-restricted conditions, insulin also significantly amplified the capacity of estradiol and 8-bromo cyclic AMP to stimulate progesterone production.	Progesterone	134-146	insulin	Sus scrofa	35-42	
6193139-8	1983	The stimulation of progesterone production by insulin was attributable to increased biosynthesis of pregnenolone, rather than diminished catabolism of progesterone to its principal metabolite, 20alpha-hydroxypregn-4-en-3-one.	Progesterone	19-31	insulin	Sus scrofa	46-53	
6193139-9	1983	Insulin also enhanced progesterone production in the presence of a soluble sterol substrate, 5-cholesten-3beta,25-diol, which readily gains access to the mitochondrial cholesterol side-chain cleavage system.	Progesterone	22-34	insulin	Sus scrofa	0-7	
6193139-12	1983	Insulin"s augmentation of progesterone production reflected a selective action on progestin biosynthesis, since insulin significantly suppressed estrogen biosynthesis by granulosa cells.Thus, our investigations indicate that insulin acts on ovarian cells selectively to stimulate pregnenolone (but not estrogen) biosynthesis.	Progesterone	26-38	insulin	Sus scrofa	0-7	
6193139-12	1983	Insulin"s augmentation of progesterone production reflected a selective action on progestin biosynthesis, since insulin significantly suppressed estrogen biosynthesis by granulosa cells.Thus, our investigations indicate that insulin acts on ovarian cells selectively to stimulate pregnenolone (but not estrogen) biosynthesis.	Progesterone	26-38	insulin	Sus scrofa	225-232	
33189079-3	2021	Therefore, this study aimed to investigate the in vitro effect of chemerin on basal and luteinizing hormone/follicle-stimulating hormone- and/or insulin-induced secretion of progesterone (P4), androstenedione (A4), testosterone (T), estrone (E1) and estradiol (E2) by the porcine ovarian cells during the estrous cycle and early pregnancy.	Progesterone	174-186	insulin	Sus scrofa	145-152	
11133694-0	2001	Feed restriction and insulin treatment affect subsequent luteal function in the immediate postovulatory period in pigs: progesterone production in vitro and messenger ribonucleic acid expression for key steroidogenic enzymes.	Progesterone	120-132	insulin	Sus scrofa	21-28	
11133694-6	2001	Inherent differences in luteal function therefore appear to mediate latent effects of nutrition and insulin treatment on circulating progesterone concentrations in the critical postovulatory period in gilts.	Progesterone	133-145	insulin	Sus scrofa	100-107