PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 15280552-5 2004 Analysis of the reproductive phenotypes of these mice has indicated that PR-A and PR-B mediate mostly distinct but partially overlapping reproductive responses to progesterone. Progesterone 163-175 progesterone receptor Mus musculus 82-86 11977981-6 2002 Lower induction of Ihh, Ptc, and Hoxa10 is seen in response to progesterone in the uteri of Pgr(-/-) mutant mice lacking progesterone nuclear steroid receptor. Progesterone 63-75 progesterone receptor Mus musculus 92-95 14667967-0 2003 Progesterone-dependent regulation of female reproductive activity by two distinct progesterone receptor isoforms. Progesterone 0-12 progesterone receptor Mus musculus 82-103 14667967-4 2003 More recently, selective ablation of the PR-A and PR-B proteins in mice had facilitated examination of the contribution of the individual PR isoforms to the pleiotropic reproductive activities of progesterone. Progesterone 196-208 progesterone receptor Mus musculus 50-54 14667967-5 2003 Analysis of the phenotypic consequences of these mutations on female reproductive function has provided proof of concept that the distinct transcriptional responses to PR-A and PR-B observed in cell-based transactivation assays are reflected in a distinct tissue-selective contribution of the individual isoforms to the reproductive activities of progesterone. Progesterone 347-359 progesterone receptor Mus musculus 177-181 14667968-3 2003 Towards this end, the progesterone receptor knockout (PRKO) mouse demonstrated that progesterone is essential for pregnancy-associated mammary gland ductal side-branching and alveologenesis and that these morphological changes are dependent on progesterone-induced mammary epithelial proliferation. Progesterone 84-96 progesterone receptor Mus musculus 22-43 12604642-3 2003 Previous studies have revealed that the cellular ratio of the PR isoforms is important for progesterone-responsive tissues and is under developmental control in different species. Progesterone 91-103 progesterone receptor Mus musculus 62-64 12444077-1 2002 In mice deficient in progesterone receptor (PR), follicles of ovulatory size develop but fail to ovulate, providing evidence for an essential role for progesterone and PR in ovulation in mice. Progesterone 21-33 progesterone receptor Mus musculus 44-46 12444077-1 2002 In mice deficient in progesterone receptor (PR), follicles of ovulatory size develop but fail to ovulate, providing evidence for an essential role for progesterone and PR in ovulation in mice. Progesterone 21-33 progesterone receptor Mus musculus 168-170 14982969-0 2004 Anticonvulsant activity of progesterone and neurosteroids in progesterone receptor knockout mice. Progesterone 27-39 progesterone receptor Mus musculus 61-82 14973372-8 2003 In ovariectomized mice supplemented with estradiol but lacking measurable progesterone, PR-B-expressing tumors grow to twice the size of PR-A-expressing ones. Progesterone 74-86 progesterone receptor Mus musculus 88-92 11518735-8 2001 Furthermore, reintroduction of PR into PRKO-derived VSMCs using adenoviral methods restored progesterone-mediated inhibition of proliferation to these cells. Progesterone 92-104 progesterone receptor Mus musculus 31-33 12017551-2 2002 Physiological effects of progesterone are mediated by interaction of the hormone with specific intracellular progesterone receptors (PRs) that are expressed as two protein isoforms, PR-A and PR-B. Progesterone 25-37 progesterone receptor Mus musculus 191-195 12017551-6 2002 First, analysis of the structural and functional relationships of each isoform using in vitro systems has generated compelling evidence to support the conclusion that PR-A and PR-B have different transcription activation properties when liganded to progesterone. Progesterone 249-261 progesterone receptor Mus musculus 176-180 12017551-8 2002 Selective ablation of PR-A and PR-B proteins in mice using these technologies has allowed us to address the spatiotemporal expression and contribution of the individual PR isoforms to the pleiotropic reproductive activities of progesterone. Progesterone 227-239 progesterone receptor Mus musculus 31-35 12017551-9 2002 Analysis of the phenotypic consequences of these mutations on female reproductive function has provided proof of concept that the distinct transcriptional responses to PR-A and PR-B observed in cell-based transactivation assays are, indeed, reflected in an ability of the individual isoforms to elicit distinct, physiological responses to progesterone. Progesterone 339-351 progesterone receptor Mus musculus 177-181 12017551-12 2002 These tissue-selective activities of PR-B are due to this isoform"s ability to regulate a subset of progesterone-responsive target genes in reproductive tissues rather than to differences in its spatiotemporal expression relative to the PR-A isoform. Progesterone 100-112 progesterone receptor Mus musculus 37-41 11313721-10 2001 Progesterone inhibited uterine epithelial apoptosis only in tissue recombinants prepared with PR-positive stroma. Progesterone 0-12 progesterone receptor Mus musculus 94-96 10976068-3 2000 By selective ablation of PR-A in mice, we show that the PR-B isoform modulates a subset of reproductive functions of progesterone by regulation of a subset of progesterone-responsive target genes. Progesterone 117-129 progesterone receptor Mus musculus 56-60 11133684-9 2001 This study suggests that up-regulation of PR in endometrial stroma is mediated through at least three mechanisms: 1) classical estrogen signaling through ERalpha, 2) estrogen signaling through ERbeta, and 3) as a result of mechanical stimulation plus progesterone, which induces stromal cells to differentiate into decidual cells. Progesterone 251-263 progesterone receptor Mus musculus 42-44 10976068-3 2000 By selective ablation of PR-A in mice, we show that the PR-B isoform modulates a subset of reproductive functions of progesterone by regulation of a subset of progesterone-responsive target genes. Progesterone 159-171 progesterone receptor Mus musculus 56-60 14973394-4 2000 Use of these mice in combination with mammary gland transplantation indicates that developmental regulation by progesterone appears to occur through a paracrine mechanism in which progesterone receptor (PR) positive cells represent a subset of non-proliferating epithelial cells that are capable of directing proliferation and/or differentiation of neighboring receptor negative cells. Progesterone 111-123 progesterone receptor Mus musculus 180-201 14973394-4 2000 Use of these mice in combination with mammary gland transplantation indicates that developmental regulation by progesterone appears to occur through a paracrine mechanism in which progesterone receptor (PR) positive cells represent a subset of non-proliferating epithelial cells that are capable of directing proliferation and/or differentiation of neighboring receptor negative cells. Progesterone 111-123 progesterone receptor Mus musculus 203-205 8603049-3 1996 In most tissues studied, the PR is induced by ovarian estrogen via the estrogen receptor (ER), thereby implying that many of the observed reproductive physiological responses attributed to PR could conceivably be due to the combined effects of progesterone and estrogen. Progesterone 244-256 progesterone receptor Mus musculus 29-31 9435255-5 1998 Because progesterone is a mitogenic hormone in mammary glands and PR is required for mammary development, these data provide direct evidence that in vivo a regulated expression of the two isoforms of PR is critical for appropriate cellular response to progesterone and that for mammary glands this may have major implications to carcinogenesis. Progesterone 8-20 progesterone receptor Mus musculus 200-202 8961281-8 1996 We conclude that multiple signal transduction pathways coexist in the neuroendocrine system for reproductive behavior, with PR acting as a transcriptional mediator for dopamine, as well as progesterone, to achieve integration of neural communication in the central nervous system. Progesterone 189-201 progesterone receptor Mus musculus 124-126 10727250-1 2000 The objective of this study was to determine whether uterine stromal and/or epithelial progesterone receptor (PR) is required for the antagonism by progesterone (P(4)) of estradiol-17beta (E(2)) action on expression of PR and lactoferrin in uterine epithelium. Progesterone 87-99 progesterone receptor Mus musculus 110-112 9560231-1 1998 Recently generated progesterone receptor (PR)-negative (PR-/-) mice provide an excellent model for dissecting the role of progesterone in the development of the mammary gland during puberty and pregnancy. Progesterone 19-31 progesterone receptor Mus musculus 42-44 9560231-1 1998 Recently generated progesterone receptor (PR)-negative (PR-/-) mice provide an excellent model for dissecting the role of progesterone in the development of the mammary gland during puberty and pregnancy. Progesterone 19-31 progesterone receptor Mus musculus 56-58 7557380-2 1995 The physiological effects of progesterone are mediated by the progesterone receptor (PR), a member of the nuclear receptor superfamily of transcription factors. Progesterone 29-41 progesterone receptor Mus musculus 62-83 7557380-2 1995 The physiological effects of progesterone are mediated by the progesterone receptor (PR), a member of the nuclear receptor superfamily of transcription factors. Progesterone 29-41 progesterone receptor Mus musculus 85-87 7557380-3 1995 In most cases the PR is induced by estrogen, implying that many of the in vivo effects attributed to progesterone could also be the result of concomitantly administered estrogen. Progesterone 101-113 progesterone receptor Mus musculus 18-20 34502315-11 2021 Moreover, CD73 expression was increased when estrogen and progesterone were co-administered and was inhibited by the pretreatment of the progesterone receptor antagonist RU486. Progesterone 58-70 progesterone receptor Mus musculus 137-158 34379733-5 2021 Using transgenic mice lacking PGR exclusively in kisspeptin cells (termed KissPRKOs), we previously demonstrated that progesterone action specifically in kisspeptin cells is essential for ovulation and normal fertility. Progesterone 118-130 progesterone receptor Mus musculus 30-33 34379733-9 2021 We found that targeted upregulation of PGR in kisspeptin neurons exclusively in the AVPV is sufficient to restore proper E2-induced LH surges in KissPRKO females, suggesting that this specific kisspeptin population is a key target of the necessary progesterone action for the surge. Progesterone 248-260 progesterone receptor Mus musculus 39-42 35430461-5 2022 In addition, inhibiting IL-27 signaling with IL-27 neutralization antibody (anti-IL-27) suppressed the expression of decidualization-related molecules, receptors of estrogen (gene coded by ESR) and progesterone (PGR) induced by cAMP or estrogen plus progesterone. Progesterone 198-210 progesterone receptor Mus musculus 212-215 34344445-0 2021 Progesterone receptor antagonists reverse stem cell expansion and the paracrine effectors of progesterone action in the mouse mammary gland. Progesterone 93-105 progesterone receptor Mus musculus 0-21 34344445-18 2021 CONCLUSIONS: PR inhibition reverses known tumorigenic pathways in the mammary gland and suppresses a previously unknown effect of progesterone on RNA splicing events. Progesterone 130-142 progesterone receptor Mus musculus 13-15 35430461-5 2022 In addition, inhibiting IL-27 signaling with IL-27 neutralization antibody (anti-IL-27) suppressed the expression of decidualization-related molecules, receptors of estrogen (gene coded by ESR) and progesterone (PGR) induced by cAMP or estrogen plus progesterone. Progesterone 250-262 progesterone receptor Mus musculus 212-215 35498436-3 2022 Acting through the nuclear progesterone receptor (PGR), progesterone prepares the endometrium for implantation of the embryo. Progesterone 56-68 progesterone receptor Mus musculus 27-48 35468896-4 2022 Mechanistically, stimulation of PGR by progesterone activates the tyrosine kinase SRC, which phosphorylates the transcriptional factor IRF3 at Y107, leading to its activation and induction of antiviral genes. Progesterone 39-51 progesterone receptor Mus musculus 32-35 35498436-3 2022 Acting through the nuclear progesterone receptor (PGR), progesterone prepares the endometrium for implantation of the embryo. Progesterone 56-68 progesterone receptor Mus musculus 50-53 31809260-4 2020 With the aforementioned as historical backdrop, this review focusses on a selection of key advances in our understanding of the molecular mechanisms by which progesterone, through its nuclear receptor (the progesterone receptor), drives the development of endometrial receptivity, a transient uterine state that allows for embryo implantation and the establishment of pregnancy. Progesterone 158-170 progesterone receptor Mus musculus 206-227 35134138-8 2022 Interestingly, progesterone receptor knockout mice, which lack progesterone signaling, also have defects in post-pubertal uterine gland development. Progesterone 63-75 progesterone receptor Mus musculus 15-36 32915211-1 2020 The physiological functions of progesterone (P4) in female reproductive organs including the mammary glands are mediated via the progesterone receptor (PR), but not all P4 functions can be explained by PR-mediated signaling. Progesterone 31-43 progesterone receptor Mus musculus 129-150 32915211-1 2020 The physiological functions of progesterone (P4) in female reproductive organs including the mammary glands are mediated via the progesterone receptor (PR), but not all P4 functions can be explained by PR-mediated signaling. Progesterone 31-43 progesterone receptor Mus musculus 152-154 3398533-4 1988 In the case of the adult gland, the mitogenic effects of progesterone appear to be related to the presence of E-dependent progesterone receptors (PgR). Progesterone 57-69 progesterone receptor Mus musculus 146-149 34057651-9 2021 RESULTS: In T-47D-xenografted tumors, estrogen and progesterone treatment reduced PGR and KI67 mRNA expression, and reduced PR and Ki67 protein positivity, compared to estrogen treatment alone. Progesterone 51-63 progesterone receptor Mus musculus 82-85 33099617-2 2020 Uterine PGR responds to the heightened levels of ovarian progesterone (P4) after ovulation and regulates uterine gene transcription for successful embryo implantation. Progesterone 57-69 progesterone receptor Mus musculus 8-11 30328351-5 2018 Progesterone treatment could induce TMEM16A expression in endometrial stromal cells through progesterone receptor/c-Myc pathway, which is blocked by progesterone receptor antagonist or the inhibitor of c-Myc signaling pathway. Progesterone 0-12 progesterone receptor Mus musculus 92-113 32295179-3 2020 It is known that progesterone promotes the proliferation and differentiation of OPC in early postnatal life through the activation of the intracellular progesterone receptor (PR). Progesterone 17-29 progesterone receptor Mus musculus 152-173 32295179-3 2020 It is known that progesterone promotes the proliferation and differentiation of OPC in early postnatal life through the activation of the intracellular progesterone receptor (PR). Progesterone 17-29 progesterone receptor Mus musculus 175-177 32295179-5 2020 However, the role of progesterone in embryonic OPC differentiation as well as the specific PR isoform involved in progesterone actions in these cells is unknown. Progesterone 114-126 progesterone receptor Mus musculus 91-93 32295179-7 2020 We found that progesterone increases the proliferation, differentiation, and myelination potential of embryonic OPC through its PR by upregulating the expression of oligodendroglial genes such as neuron/glia antigen 2 (NG2), sex determining region Y-box9 (SOX9), myelin basic protein (MBP), 2",3"-cyclic-nucleotide 3"-phosphodiesterase (CNP1), and NK6 homeobox 1 (NKX 6.1). Progesterone 14-26 progesterone receptor Mus musculus 128-130 32295179-9 2020 The results suggest that progesterone contributes to the process of oligodendrogenesis during prenatal life through specific activation of PR-B. Progesterone 25-37 progesterone receptor Mus musculus 139-143 31647947-7 2019 In vitro, progesterone increased glucose uptake in primary cultured cortical neurons, this effect was blocked by the progesterone receptor membrane component 1 (PGRMC1)-specific blocker AG205 but not by the progesterone receptor (PR)-specific blocker RU486. Progesterone 10-22 progesterone receptor Mus musculus 117-138 31647947-7 2019 In vitro, progesterone increased glucose uptake in primary cultured cortical neurons, this effect was blocked by the progesterone receptor membrane component 1 (PGRMC1)-specific blocker AG205 but not by the progesterone receptor (PR)-specific blocker RU486. Progesterone 10-22 progesterone receptor Mus musculus 230-232 31091357-7 2019 Progesterone receptor antagonist (mifepristone) or knock-down DAF with specific siRNA, above the protective effects of progesterone, were significantly weakened. Progesterone 119-131 progesterone receptor Mus musculus 0-21 30328351-5 2018 Progesterone treatment could induce TMEM16A expression in endometrial stromal cells through progesterone receptor/c-Myc pathway, which is blocked by progesterone receptor antagonist or the inhibitor of c-Myc signaling pathway. Progesterone 0-12 progesterone receptor Mus musculus 149-170 29705365-4 2018 Progesterone receptor isoforms collectively mediate progesterone signaling via their distinct and common downstream target genes, which makes the stoichiometry of isoforms relevant in modifying the progesterone activity. Progesterone 52-64 progesterone receptor Mus musculus 0-21 29705365-4 2018 Progesterone receptor isoforms collectively mediate progesterone signaling via their distinct and common downstream target genes, which makes the stoichiometry of isoforms relevant in modifying the progesterone activity. Progesterone 198-210 progesterone receptor Mus musculus 0-21 27511308-9 2017 These results suggest that PR overexpression in endometrial stromal cells, likely due to high progesterone levels, triggers cyclin D3 and Hoxa-10 overexpression, which may be involved in the pathological mechanisms of the mouse uterine decidual reaction. Progesterone 94-106 progesterone receptor Mus musculus 27-29 29902902-9 2018 Western blot analysis showed that Yunkang oral liquid and progesterone can significantly increase the expressions of PRLR, PR in the uterine decidua of RSA mice, and the expression of ER in Yunkang group was higher than that in progesterone group. Progesterone 58-70 progesterone receptor Mus musculus 117-119 28911214-6 2017 Wild-type and progesterone receptor (PR) knockout mice were treated with progesterone, and their uteri were assessed for levels of GREB1 expression. Progesterone 14-26 progesterone receptor Mus musculus 37-39 28701790-5 2017 Here, we identify a molecular mechanism by which progesterone promotes neurite outgrowth through mPRbeta (Paqr8) activation. Progesterone 49-61 progesterone receptor Mus musculus 97-104 27500900-5 2016 Using co-immunoprecipitation assays, we observed the constitutive activation of nuclear factor kappa-b (NF-kappaB) p65 and its interaction with the progesterone receptor (PGR); moreover, transcriptional activity of the PGR was also repressed by NF-kappaB activity in primary mouse and human decidual stromal cells that mimic progesterone maintenance. Progesterone 148-160 progesterone receptor Mus musculus 171-174 27786501-8 2016 Our results show that both facilitation and sequential inhibition of lordosis induced by progesterone require the presence of the progesterone receptor. Progesterone 89-101 progesterone receptor Mus musculus 130-151 27500900-5 2016 Using co-immunoprecipitation assays, we observed the constitutive activation of nuclear factor kappa-b (NF-kappaB) p65 and its interaction with the progesterone receptor (PGR); moreover, transcriptional activity of the PGR was also repressed by NF-kappaB activity in primary mouse and human decidual stromal cells that mimic progesterone maintenance. Progesterone 148-160 progesterone receptor Mus musculus 219-222 24916968-2 2014 Progesterone receptor (PGR) is a transcription factor highly expressed in oviductal cells, while its activating ligand, progesterone, surges to peak levels as ovulation approaches. Progesterone 120-132 progesterone receptor Mus musculus 0-21 27007157-3 2016 We found that epithelial PR was required for induction of apoptosis and suppression of cell proliferation by progesterone (P4) in the cervical and vaginal epithelium. Progesterone 109-121 progesterone receptor Mus musculus 25-27 26804062-1 2016 The steroid hormone progesterone (P), acting via the progesterone receptor (PR) isoforms, PR-A and PR-B, exerts a profound influence on uterine functions during early gestation. Progesterone 20-32 progesterone receptor Mus musculus 53-74 26804062-1 2016 The steroid hormone progesterone (P), acting via the progesterone receptor (PR) isoforms, PR-A and PR-B, exerts a profound influence on uterine functions during early gestation. Progesterone 20-32 progesterone receptor Mus musculus 76-78 26804062-1 2016 The steroid hormone progesterone (P), acting via the progesterone receptor (PR) isoforms, PR-A and PR-B, exerts a profound influence on uterine functions during early gestation. Progesterone 20-32 progesterone receptor Mus musculus 99-103 26275946-10 2015 Finally, by in silico analysis, we identified that mPRalpha, mPRbeta and mPRgamma promoters contain several progesterone and estrogen response elements. Progesterone 108-120 progesterone receptor Mus musculus 61-68 26369614-3 2015 We also demonstrated the role of the progesterone receptor (PR) in inhibiting inflammation and reactive gliosis, and in enhancing the survival of oligodendrocyte progenitors cells (OPC) in injured PR knockout (PRKO) mice receiving progesterone. Progesterone 37-49 progesterone receptor Mus musculus 60-62 26369614-8 2015 Our results support a role of PR in: (a) the anti-inflammatory effects of progesterone; (b) the modulation of astrocyte and microglial responses and (c) the prevention of OPC apoptosis, a mechanism that would enhance the commitment of progenitors to the remyelination pathway in the injured spinal cord. Progesterone 74-86 progesterone receptor Mus musculus 30-32 24916968-2 2014 Progesterone receptor (PGR) is a transcription factor highly expressed in oviductal cells, while its activating ligand, progesterone, surges to peak levels as ovulation approaches. Progesterone 120-132 progesterone receptor Mus musculus 23-26 22155565-1 2012 The ovarian steroid progesterone, acting through the progesterone receptor (PR), coordinates endometrial epithelial-stromal cell communication, which is critical for its development and function. Progesterone 20-32 progesterone receptor Mus musculus 53-74 23744837-1 2013 Progesterone, an agonist for the progesterone receptor (PR), can be an efficacious and well-tolerated treatment in endometrial cancer. Progesterone 0-12 progesterone receptor Mus musculus 33-54 23744837-1 2013 Progesterone, an agonist for the progesterone receptor (PR), can be an efficacious and well-tolerated treatment in endometrial cancer. Progesterone 0-12 progesterone receptor Mus musculus 56-58 23744837-6 2013 Stromal deletion of PR as a single genetic change in these tumors induced progesterone resistance indicating that paracrine signaling through the stroma is essential for the progesterone therapeutic effects. Progesterone 74-86 progesterone receptor Mus musculus 20-22 23744837-6 2013 Stromal deletion of PR as a single genetic change in these tumors induced progesterone resistance indicating that paracrine signaling through the stroma is essential for the progesterone therapeutic effects. Progesterone 174-186 progesterone receptor Mus musculus 20-22 23744837-9 2013 Add-back of stromal PR expressed from a constitutively active promoter sensitized these tumors to progesterone therapy. Progesterone 98-110 progesterone receptor Mus musculus 20-22 23744837-11 2013 Our findings suggest that epigenetic derepression of stromal PR could be a potential therapeutic target for sensitizing hormone-refractory endometrial tumors to progesterone therapy. Progesterone 161-173 progesterone receptor Mus musculus 61-63 23810007-1 2013 Progesterone receptor (PR) belongs to the superfamily of steroid receptors and mediates the action of progesterone in its target tissues. Progesterone 102-114 progesterone receptor Mus musculus 0-21 23810007-1 2013 Progesterone receptor (PR) belongs to the superfamily of steroid receptors and mediates the action of progesterone in its target tissues. Progesterone 102-114 progesterone receptor Mus musculus 23-25 22993382-2 2012 Previously, we showed that the transcription factor Kruppel-like factor (KLF) 9 is a progesterone receptor (PGR) coactivator in the uterus and that mice null for Klf9 exhibit subfertility and reduced progesterone sensitivity. Progesterone 85-97 progesterone receptor Mus musculus 108-111 22638070-5 2012 Sequence analysis revealed that approximately 73% of these binding sites contain a progesterone response element or a half-site motif recognized by the PR. Progesterone 83-95 progesterone receptor Mus musculus 152-154 23827354-5 2013 Immunoblotting assays indicated that either PR agonist progesterone (P4) or PR-B over-expression promoted the PIC-induced reinforces of extracellular-signal-regulated kinase 1/2 phosphorylation (p-Erk) and protein 53 (p53), and the attenuations of protein kinase B phosphorylation (p-AKT) and tumor necrosis factor receptor-associated factor 2 (TRAF2). Progesterone 55-67 progesterone receptor Mus musculus 44-46 24065879-1 2013 It is clear from studies using progesterone receptor (PGR) mutant mice that not all of the actions of progesterone (P4) are mediated by this receptor. Progesterone 31-43 progesterone receptor Mus musculus 54-57 23531596-9 2013 The expression of stromal PR was decreased during decidualization and preimplantation period in Stat3(d/d) mice, and PR target genes were significantly down-regulated after progesterone induction. Progesterone 173-185 progesterone receptor Mus musculus 117-119 23702927-3 2013 Early progesterone receptor (PR) antagonists, however, were dismissed because of severe side effects, but awareness is now increasing that progesterone is an important hormone in breast cancer. Progesterone 6-18 progesterone receptor Mus musculus 29-31 22155565-1 2012 The ovarian steroid progesterone, acting through the progesterone receptor (PR), coordinates endometrial epithelial-stromal cell communication, which is critical for its development and function. Progesterone 20-32 progesterone receptor Mus musculus 76-78 20410205-2 2010 We previously showed that mice null for the progesterone receptor (PGR)-interacting protein Kruppel-like factor (KLF) 9 are subfertile and exhibit reduced uterine progesterone sensitivity. Progesterone 44-56 progesterone receptor Mus musculus 67-70 21901819-4 2011 When 100 nM progesterone was added during differentiation, we found higher proportions of MN, compared to the control condition; coincubation of progesterone with the progesterone receptor (PR) antagonist RU-486 caused a decrease in the number of MN to a percentage even lower than controls. Progesterone 12-24 progesterone receptor Mus musculus 167-188 21901819-4 2011 When 100 nM progesterone was added during differentiation, we found higher proportions of MN, compared to the control condition; coincubation of progesterone with the progesterone receptor (PR) antagonist RU-486 caused a decrease in the number of MN to a percentage even lower than controls. Progesterone 12-24 progesterone receptor Mus musculus 190-192 21187471-10 2010 The hypothesis that the cancer cells have the capacity to direct local progesterone production is supported by demonstrating the benefit of a progesterone receptor antagonist in tumors restricted to males. Progesterone 71-83 progesterone receptor Mus musculus 142-163 21901819-13 2011 Our findings indicate that progesterone and 17beta-estradiol induce a higher proportion of MN derived from mouse ES cells through intracellular PR and ER, respectively. Progesterone 27-39 progesterone receptor Mus musculus 144-146 20844199-5 2010 Stimulation of the PR (with progesterone and norgestrel) by pretreatment of DCs was found to sustain IFN regulatory factor-3 phosphorylation following TLR3 ligation, but not TLR4 ligation. Progesterone 28-40 progesterone receptor Mus musculus 19-21 20713718-1 2010 Immunophilin FK506-binding protein 52 (FKBP52) is a cochaperone that binds to the progesterone receptor (PR) to optimize progesterone (P(4))-PR signaling. Progesterone 82-94 progesterone receptor Mus musculus 105-107 20713718-1 2010 Immunophilin FK506-binding protein 52 (FKBP52) is a cochaperone that binds to the progesterone receptor (PR) to optimize progesterone (P(4))-PR signaling. Progesterone 82-94 progesterone receptor Mus musculus 141-143 19841944-5 2009 In the ovariectomized mouse uterus, the expression of Adam12 is upregulated after progesterone treatment, which is primarily mediated by nuclear progesterone receptor. Progesterone 82-94 progesterone receptor Mus musculus 145-166 20029965-5 2010 Therefore, this conditional mouse model for PR ablation represents an invaluable resource with which to further define in a developmental and/or reproductive stage-specific manner the individual and integrative roles of distinct PR populations resident in multiple progesterone-responsive target sites. Progesterone 265-277 progesterone receptor Mus musculus 229-231 18625316-0 2008 Synthesis and biological effect of halogen substituted phenyl acetic acid derivatives of progesterone as potent progesterone receptor antagonists. Progesterone 89-101 progesterone receptor Mus musculus 112-133 19325006-6 2009 Furthermore, using both a pharmacological inhibitor of the progesterone receptor (PR) and PR knockout mice, we determined that the effects of progesterone were mediated by the classical PR. Progesterone 59-71 progesterone receptor Mus musculus 82-84 18687774-9 2008 In sum, the progesterone-responsive transcriptome described herein not only reinforces the importance of progesterone in mammary epithelial expansion but also represents an invaluable information resource with which to identify novel signaling paradigms for mammary PR action. Progesterone 12-24 progesterone receptor Mus musculus 266-268 18692819-11 2009 In the ovariectomized mouse uterus, Gstm2 expression was strongly up-regulated by progesterone via progesterone receptor. Progesterone 82-94 progesterone receptor Mus musculus 99-120 19403993-3 2009 Pregnenolone is then metabolized to progesterone, an activator of progesterone receptor, and further metabolized to produce allopregnanolone and 3alpha,21-dihydroxy-5alpha-pregnan-20-one (3alpha,5alpha-THDOC), positive allosteric modulators and activators of the GABA(A) receptor. Progesterone 36-48 progesterone receptor Mus musculus 66-87 18253697-9 2009 Progesterone suppressed MC3T3-E1 cells apoptosis induced by serum deprivation, and this effect was blocked by a PR antagonist RU486. Progesterone 0-12 progesterone receptor Mus musculus 112-114 18239353-12 2008 In conclusion, LIF, which has a crucial role in E2 action for initiation of implantation, caused transient induction of Pgr mRNA and subsequent upregulation of Ihh mRNA, which mediates progesterone-Pgr actions for successful implantation. Progesterone 185-197 progesterone receptor Mus musculus 198-201 18174919-2 2007 A selective gene-knockout approach applied to the mouse, which abrogates gene function only in cell types that express PR, recently disclosed steroid receptor coactivator 2 (SRC-2, also known as TIF-2 or GRIP-1) to be an indispensable coregulator for uterine and mammary gland responses that require progesterone. Progesterone 300-312 progesterone receptor Mus musculus 119-121 18197783-1 2008 Progesterone acting through two isoforms of the progesterone receptor (PR), PRA and PRB, regulates proliferation and differentiation in the normal mammary gland in mouse, rat, and human. Progesterone 0-12 progesterone receptor Mus musculus 48-69 18197783-1 2008 Progesterone acting through two isoforms of the progesterone receptor (PR), PRA and PRB, regulates proliferation and differentiation in the normal mammary gland in mouse, rat, and human. Progesterone 0-12 progesterone receptor Mus musculus 71-73 18197783-1 2008 Progesterone acting through two isoforms of the progesterone receptor (PR), PRA and PRB, regulates proliferation and differentiation in the normal mammary gland in mouse, rat, and human. Progesterone 0-12 progesterone receptor Mus musculus 84-87 17317767-1 2007 In normal mouse mammary gland, the mitogenic action of progesterone (P) is mediated by two P receptor (PR) isoforms, PRA and PRB. Progesterone 55-67 progesterone receptor Mus musculus 125-128 17941046-4 2007 Crossed with the TZA reporter, which carries the TetO-LacZ responder transgene, the PR(+/rtTA)/TZA and PR(rtTA/rtTA)/TZA bigenics exhibit doxycycline-induced beta-galactosidase activity specifically in progesterone responsive target tissues such as the mammary gland, uterus, ovary, and pituitary gland. Progesterone 202-214 progesterone receptor Mus musculus 84-86 17941046-4 2007 Crossed with the TZA reporter, which carries the TetO-LacZ responder transgene, the PR(+/rtTA)/TZA and PR(rtTA/rtTA)/TZA bigenics exhibit doxycycline-induced beta-galactosidase activity specifically in progesterone responsive target tissues such as the mammary gland, uterus, ovary, and pituitary gland. Progesterone 202-214 progesterone receptor Mus musculus 103-105 18543434-7 2007 Finally, two distinct isoforms of PRs (PR-A and PR-B) are coexpressed in the mammary gland and display extensively overlapping but partially distinct gene regulatory properties in relaying the progesterone signal. Progesterone 193-205 progesterone receptor Mus musculus 48-52 16973758-11 2007 These results define a negative cross talk between PR and Stat5a/GR that may contribute to the physiological role of progesterone to repress lactogenic hormone induction of the beta-casein gene in the mammary gland during pregnancy. Progesterone 117-129 progesterone receptor Mus musculus 51-53 17003284-6 2006 Exposure of E(2)-treated pituitary cells to 200 nM progesterone for 6 h decreased both PR-A and PR-B levels in rat cells, but had no effect on PR isoform expression in mouse cells even when exposure was extended to 12 h. The low level of PR expression found in LbetaT2 gonadotropes was unaffected by E(2), alone or with progesterone. Progesterone 51-63 progesterone receptor Mus musculus 96-98 16799639-10 2006 Furthermore, we observed that inhibition of caveolin-1 expression abrogated PR capacity to induced luciferase activity from a progesterone response element-driven reporter plasmid. Progesterone 126-138 progesterone receptor Mus musculus 76-78 16135805-7 2005 In contrast, SRC-1 was involved in the down-regulation of PR target gene expression in the luminal and glandular epithelial compartments of the uterus after chronic progesterone treatment. Progesterone 165-177 progesterone receptor Mus musculus 58-60 16899559-7 2006 The rank order of the potencies of several progestins in activating MAPK via mPRalpha and mPRbeta was the same (17,20beta-DHP>progesterone >4-pregnen-17,20beta,21-triol-3-one). Progesterone 129-141 progesterone receptor Mus musculus 90-97 16728408-4 2006 A small interfering RNA knockdown of type I GnRH receptor levels reduced PR activation by GnRHs, while progesterone-dependent PR activation was unaffected. Progesterone 103-115 progesterone receptor Mus musculus 126-128 16141356-3 2006 In the mammary gland, PR activity in the luminal epithelium of both wild-type and SRC-1(-/-) mice was induced by estrogen + progesterone treatment. Progesterone 124-136 progesterone receptor Mus musculus 22-24 16141356-5 2006 In the uterus, PR activity in the stroma compartment of both wild-type and SRC-3(-/-) mice was induced by estrogen + progesterone treatment. Progesterone 117-129 progesterone receptor Mus musculus 15-17 15845616-1 2005 Progesterone (P4) acting through its cognate receptor, the progesterone receptor (PR), plays an important role in uterine physiology. Progesterone 0-12 progesterone receptor Mus musculus 59-80 15845616-1 2005 Progesterone (P4) acting through its cognate receptor, the progesterone receptor (PR), plays an important role in uterine physiology. Progesterone 0-12 progesterone receptor Mus musculus 82-84