PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 16109739-5 2006 On the other hand, knockdown of endogenous BRCA1 using small interfering RNA enhanced the progesterone-stimulated activity of the PR by about 4-fold. Progesterone 90-102 BRCA1 DNA repair associated Homo sapiens 43-48 16109739-9 2006 Thus, we showed that BRCA1 inhibits the expression of various endogenous progesterone-responsive genes and inhibits progesterone-stimulated proliferation of T47D cells. Progesterone 73-85 BRCA1 DNA repair associated Homo sapiens 21-26 15816544-9 2005 CONCLUSION: The down-regulation of BRCA1 in MCF7 cells incubated with 10(-4) M progesterone seems to be a consequence of cell cycle alterations rather than a direct effect of the hormone on BRCA1. Progesterone 79-91 BRCA1 DNA repair associated Homo sapiens 35-40 15816544-9 2005 CONCLUSION: The down-regulation of BRCA1 in MCF7 cells incubated with 10(-4) M progesterone seems to be a consequence of cell cycle alterations rather than a direct effect of the hormone on BRCA1. Progesterone 79-91 BRCA1 DNA repair associated Homo sapiens 190-195 35418083-4 2022 Here, we provide a review of the emerging preclinical and epidemiologic evidence implicating the dysregulation of progesterone-mediated receptor activator of nuclear factor kappaB (RANK) signaling in the pathogenesis of BRCA1-associated breast cancer. Progesterone 114-126 BRCA1 DNA repair associated Homo sapiens 220-225 14732925-11 2004 This is likely to lead to changes in progesterone signaling in hormone-dependent tissues, which may be a factor in the increased risk of cancer in these tissues in women with germ-line BRCA1 or BRCA2 mutations. Progesterone 37-49 BRCA1 DNA repair associated Homo sapiens 185-190 11443175-12 2001 In tissue culture medium from ovarian cells obtained from a patient with BRCA-gene mutation, concentration of progesterone in the tissue culture medium increased from 2.5 +/- 0.2 ng/mL for control to 5.4 +/- 0.3 ng/mL for cells incubated with insulin (P < 0.001). Progesterone 110-122 BRCA1 DNA repair associated Homo sapiens 73-77 21533369-9 1997 The absence of retinoic acid effect suggests that a specific progesterone-dependent pathway, could control BRCA1 expression. Progesterone 61-73 BRCA1 DNA repair associated Homo sapiens 107-112 11720902-5 2001 Using an in vivo protocol to artificially induce mammary gland development, we demonstrated by the real-time RT-PCR method that growth hormone in association with estrogen, progesterone and hydrocortisone induces an increase of BRCA1 mRNA expression in the ewe mammary gland. Progesterone 173-185 BRCA1 DNA repair associated Homo sapiens 228-233 35418083-7 2022 Progesterone-containing (but not estrogen-alone) hormone replacement therapy is associated with an increased risk of breast cancer in women with a BRCA1 mutation. Progesterone 0-12 BRCA1 DNA repair associated Homo sapiens 147-152 27246982-8 2016 Progesterone added to estradiol treatment increased the proliferation in a subset of BRCA1+/mut breast tissues. Progesterone 0-12 BRCA1 DNA repair associated Homo sapiens 85-90 30325501-4 2019 The effect of dose response and combination treatment with mifepristone and analogs of progesterone- or glucocorticoid-receptors were investigated on BRCA1-/2- MSC in vitro using a panel of markers for proliferation (ki67, BrdU, CDK2, p21CIP ), apoptosis (BAX, BCL2, CASPASE3), tumor suppression (TP53, PTEN) and cell survival (PI3KCA, MAPK3, mTOR). Progesterone 87-99 BRCA1 DNA repair associated Homo sapiens 150-155 30325501-8 2019 CONCLUSIONS: Our study showed an anti-proliferative effect on ovarian BRCA1-/2- MSC on in vitro combined treatment with mifepristone and progesterone. Progesterone 137-149 BRCA1 DNA repair associated Homo sapiens 70-75 31771627-0 2019 BRCA1 mutation influences progesterone response in human benign mammary organoids. Progesterone 26-38 BRCA1 DNA repair associated Homo sapiens 0-5 29101208-3 2018 Remarkably, mouse Brca1+/- and human BRCA1mut/+ progenitor cells are able to form colonies in vitro in the absence of progesterone, demonstrating a hormone-independent proliferative capacity. Progesterone 118-130 BRCA1 DNA repair associated Homo sapiens 37-47 27783278-5 2017 Emerging evidence suggests that BRCA1 mutation carriers have high circulating levels of progesterone which may play a role in their susceptibility to breast cancer. Progesterone 88-100 BRCA1 DNA repair associated Homo sapiens 32-37 24140203-10 2013 INTERPRETATION: Carriers of BRCA1/BRCA2 mutations are exposed to higher titres of oestradiol and progesterone-known risk-factors for breast cancer. Progesterone 97-109 BRCA1 DNA repair associated Homo sapiens 28-33 22931600-1 2012 OBJECTIVE: To study the effect of BRCA1 in regulating the proliferation and migration of breast cancer cells stimulated by progesterone. Progesterone 123-135 BRCA1 DNA repair associated Homo sapiens 34-39 22931600-6 2012 Compared to the scrambled siRNA, BRCA1 siRNA transfection prior to progesterone stimulation significantly increased the proliferation rates [(114.4-+3.05)% vs (125.3-+4.0)%, P<0.05] and migration rate (39.2% vs 69.08%) of MCF-7 cells. Progesterone 67-79 BRCA1 DNA repair associated Homo sapiens 33-38 22931600-7 2012 The progesterone antagonist RU468 could antagonize the effects of BRCA1 knockdown in enhancing progesterone-stimulated MCF-7 cell proliferation and migration. Progesterone 4-16 BRCA1 DNA repair associated Homo sapiens 66-71