PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 15869954-6 2005 Using real-time PCR we found that progesterone treatment significantly suppressed the injury-induced upregulation of interleukin (IL)-1beta, transforming growth factor (TGF)beta2, and nitric oxide synthase (NOS)-2 mRNAs in the ipsilateral hemisphere while having no effect on tumor necrosis factor (TNF)-alpha mRNA expression. Progesterone 34-46 nitric oxide synthase 2, inducible Mus musculus 184-213 15857396-0 2005 Modulatory effects of progesterone on inducible nitric oxide synthase expression in vivo and in vitro. Progesterone 22-34 nitric oxide synthase 2, inducible Mus musculus 38-69 15857396-2 2005 Previous studies investigating the therapeutic potential of female sex steroids in stroke and trauma suggest that NO from this source is harmful, since oestradiol and progesterone decreased the level of iNOS expression in vitro and improved neurological outcome. Progesterone 167-179 nitric oxide synthase 2, inducible Mus musculus 203-207 15857396-4 2005 We observed a significant reduction in stroke-induced iNOS transcript in progesterone-treated mice and in cultured macrophages. Progesterone 73-85 nitric oxide synthase 2, inducible Mus musculus 54-58 15857396-7 2005 Astrocytes transiently transfected with iNOS promoter/CAT reporter gene constructs containing the PRE displayed a significant increase in induction of CAT expression after progesterone treatment, and this was diminished in cells transfected with a construct containing a disrupted PRE. Progesterone 172-184 nitric oxide synthase 2, inducible Mus musculus 40-44 15857396-8 2005 These observations suggest the involvement of iNOS in the neuroprotective effects of progesterone. Progesterone 85-97 nitric oxide synthase 2, inducible Mus musculus 46-50 10963849-0 2000 Onapristone (ZK299) blocks the suppressive effect of progesterone, but not that of dexamethasone, on inducible nitric oxide synthase gene expression and nitric oxide production in murine macrophages. Progesterone 53-65 nitric oxide synthase 2, inducible Mus musculus 101-132 10963849-1 2000 Suppressive effects of progesterone on inducible nitric oxide synthase (iNOS) protein expression and nitric oxide (NO) production in murine peritoneal macrophages in response to bacterial lipopolysaccharide (LPS) and the inhibition of the suppressive activity of progesterone by onapristone (ZK299), a synthetic progesterone inhibitor, were studied. Progesterone 23-35 nitric oxide synthase 2, inducible Mus musculus 39-70 10963849-1 2000 Suppressive effects of progesterone on inducible nitric oxide synthase (iNOS) protein expression and nitric oxide (NO) production in murine peritoneal macrophages in response to bacterial lipopolysaccharide (LPS) and the inhibition of the suppressive activity of progesterone by onapristone (ZK299), a synthetic progesterone inhibitor, were studied. Progesterone 23-35 nitric oxide synthase 2, inducible Mus musculus 72-76 10891568-1 2000 Progesterone inhibits the transcription of inducible nitric oxide (NO) synthase (iNOS) in murine macrophages. Progesterone 0-12 nitric oxide synthase 2, inducible Mus musculus 81-85 10944423-6 2000 The iNOS was induced by estrogen and the induction was intensified when progesterone was given along with estrogen. Progesterone 72-84 nitric oxide synthase 2, inducible Mus musculus 4-8 9421794-6 1997 In uterine mast cells, iNOS and TNF-alpha are promoted by E2 whereas preliminary studies in macrophages suggest that transcription and translation of the two genes are unaffected by E2 but are inhibited by progesterone. Progesterone 206-218 nitric oxide synthase 2, inducible Mus musculus 23-27 9421794-7 1997 Uterine NK cell production of iNOS and TNF-alpha is strongly related to cell differentiation, which is initiated and sustained by progesterone. Progesterone 130-142 nitric oxide synthase 2, inducible Mus musculus 30-34 8604025-0 1996 Progesterone inhibits inducible nitric oxide synthase gene expression and nitric oxide production in murine macrophages. Progesterone 0-12 nitric oxide synthase 2, inducible Mus musculus 22-53 8604025-1 1996 The purpose of this study was to determine whether the female hormones estradiol-l7 beta (E2) and progesterone (P4) influence inducible nitric oxide synthase (iNOS) and the production of nitric oxide (NO) by interferon-gamma(IFN-gamma)-and lipopolysaccharide (LPS)-activated mouse macrophages. Progesterone 98-110 nitric oxide synthase 2, inducible Mus musculus 126-157 8604025-1 1996 The purpose of this study was to determine whether the female hormones estradiol-l7 beta (E2) and progesterone (P4) influence inducible nitric oxide synthase (iNOS) and the production of nitric oxide (NO) by interferon-gamma(IFN-gamma)-and lipopolysaccharide (LPS)-activated mouse macrophages. Progesterone 98-110 nitric oxide synthase 2, inducible Mus musculus 159-163 34699875-8 2021 M1 marks such as tumor necrosis factor alpha (TNF-alpha), inducible NOS(iNOS), interleukin-6 (IL-6), and Fc receptor (CD16 and CD32) significantly downregulated by progesterone treatment whether at 3 days or 7 days after ONC. Progesterone 164-176 nitric oxide synthase 2, inducible Mus musculus 58-71 34699875-8 2021 M1 marks such as tumor necrosis factor alpha (TNF-alpha), inducible NOS(iNOS), interleukin-6 (IL-6), and Fc receptor (CD16 and CD32) significantly downregulated by progesterone treatment whether at 3 days or 7 days after ONC. Progesterone 164-176 nitric oxide synthase 2, inducible Mus musculus 72-76 27965141-7 2017 Real time polymerase chain reaction assay indicated that administration of PG after SCI down-regulated the expression of pro-inflammatory cytokines MCP-1, NOS2, and IL-1beta (P < 0.05). Progesterone 75-77 nitric oxide synthase 2, inducible Mus musculus 155-159