PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
16734766-9	2006	However, treatment of the cells with progesterone, an inhibitor of NPC1-dependent endosomal cholesterol trafficking, not only markedly reduced the hypotonicity-provoked anion efflux, but also prevented its potentiation by cyclodextrin.	Progesterone	37-49	NPC intracellular cholesterol transporter 1	Homo sapiens	67-71	
10622400-1	1999	Progesterone inhibits intracellular transport of lysosomal cholesterol in cultured cells, and thus at least in part mimics the biochemical phenotype of Niemann-Pick type C disease (NPC) in human fibroblasts.	Progesterone	0-12	NPC intracellular cholesterol transporter 1	Homo sapiens	181-184	
10942596-6	2000	Treatment of proliferating granulosa cells with 30 microM progesterone, which induces a reversible phenocopy of the cholesterol trafficking defect of Niemann-Pick type C disease, increased NPC1 mRNA levels threefold.	Progesterone	58-70	NPC intracellular cholesterol transporter 1	Homo sapiens	189-193	
10942596-7	2000	The protein synthesis inhibitor, cycloheximide, also increased NPC1 mRNA levels, augmenting the progesterone-induced increase in NPC1 mRNA abundance.	Progesterone	96-108	NPC intracellular cholesterol transporter 1	Homo sapiens	63-67	
10942596-7	2000	The protein synthesis inhibitor, cycloheximide, also increased NPC1 mRNA levels, augmenting the progesterone-induced increase in NPC1 mRNA abundance.	Progesterone	96-108	NPC intracellular cholesterol transporter 1	Homo sapiens	129-133	
10942596-12	2000	All of the cysteine-rich loop mutants were localized to cholesterol-engorged lysosomes in a pattern mimicking the distribution of NPC1 in progesterone-treated cells.	Progesterone	138-150	NPC intracellular cholesterol transporter 1	Homo sapiens	130-134	
12622792-1	2003	The 3beta-(2-diethylaminoethoxy)-androstenone HCl (U18666A), progesterone and several cationic amphiphilic drugs have been shown to alter the trafficking of a number of intracellular membrane proteins including CD63/Lamp-3, insulin growth factor 2/mannose 6-phosphate receptor (IGF2/MPR), and the Niemann-Pick C1 gene product (NPC1) as well as ganglioside GM1.	Progesterone	61-73	NPC intracellular cholesterol transporter 1	Homo sapiens	327-331	
10662671-5	2000	Here, we report the removal of accumulated cholesterol by overexpression of the NPC-1 protein in NPC-1-deficient fibroblasts from patients with Niemann-Pick disease, and in normal fibroblasts upon release of a progesterone-induced block of cholesterol transport.	Progesterone	210-222	NPC intracellular cholesterol transporter 1	Homo sapiens	80-85	
10622400-6	1999	Progesterone also partially inhibited 25-hydroxycholesterol-induced cholesterol esterification, with similar dose-dependence in normal and NPC fibroblasts.	Progesterone	0-12	NPC intracellular cholesterol transporter 1	Homo sapiens	139-142	
9990080-8	1999	NPC1 levels in cultured fibroblasts were unchanged by incubation with low density lipoproteins or oxysterols but were increased 2- to 3-fold by the drugs progesterone and U-18666A, which block cholesterol transport out of lysosomes, and by the lysosomotropic agent NH4Cl.	Progesterone	154-166	NPC intracellular cholesterol transporter 1	Homo sapiens	0-4	
9533562-0	1998	Accumulation of cholesterol and GM2 ganglioside in cells cultured in the presence of progesterone: an implication for the basic defect in Niemann-Pick disease type C.	Progesterone	85-97	NPC intracellular cholesterol transporter 1	Homo sapiens	138-165