PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 14600408-1 2003 We have investigated the serum levels of dehydroepiandrosterone (DHEA) and DHEA sulfate (DHEAS) in type II collagen (CII)-induced arthritis (CIA) DBA/1J mice, an experimental model of human rheumatoid arthritis (RA). Dehydroepiandrosterone 41-63 nuclear receptor coactivator 5 Mus musculus 99-145 15467215-1 2004 In our previous study, we have investigated the serum levels of dehydroepiandrosterone (DHEA) in type II collagen (CII)-induced arthritis (CIA) mice. Dehydroepiandrosterone 64-86 nuclear receptor coactivator 5 Mus musculus 139-142 15467215-1 2004 In our previous study, we have investigated the serum levels of dehydroepiandrosterone (DHEA) in type II collagen (CII)-induced arthritis (CIA) mice. Dehydroepiandrosterone 88-92 nuclear receptor coactivator 5 Mus musculus 139-142 15467215-4 2004 To examine the cause of the retention of DHEA during the development of arthritis in CIA mice in this study, 17alpha-hydroxylase/C17-20 lyase P450 (CYP17) mRNA expressions were measured by real time RT-PCR and the CYP17 enzyme activities were investigated in the liver and testis on days 6, 13, 28 and 48 after CII treatment in DBA/1J mice. Dehydroepiandrosterone 41-45 nuclear receptor coactivator 5 Mus musculus 85-88 14600408-7 2003 However, in CIA mice, DHEA levels on day 28 and 48 were not decreased from those on day 6. Dehydroepiandrosterone 22-26 nuclear receptor coactivator 5 Mus musculus 12-15 14600408-10 2003 The time point for the retention of DHEA in CIA mice, day 28 and day 48, coincided with the disease onset of CIA. Dehydroepiandrosterone 36-40 nuclear receptor coactivator 5 Mus musculus 44-47 14600408-10 2003 The time point for the retention of DHEA in CIA mice, day 28 and day 48, coincided with the disease onset of CIA. Dehydroepiandrosterone 36-40 nuclear receptor coactivator 5 Mus musculus 109-112 14600408-11 2003 In conclusion, endogenous DHEA may be produced as a result of physiological response for the protection against CIA. Dehydroepiandrosterone 26-30 nuclear receptor coactivator 5 Mus musculus 112-115