PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 22661476-10 2012 CONCLUSIONS: Caspase-3 and caspase-9 are important elements in regulating HCPT-induced apoptosis in HTFs. hydroxycamptothecinum 74-78 caspase 9 Homo sapiens 27-36 23761079-8 2013 The activity levels of caspase-3 and caspase-9 were significantly increased and were accompanied by cytosolic release of cyt c and decreased DeltaPsim in response to HCPT. hydroxycamptothecinum 166-170 caspase 9 Homo sapiens 37-46 21213403-4 2011 Our results showed that the sensitivity of a combined therapy using triptolide and HCPT was higher than that of triptolide or HCPT alone and that activation of caspase-9/caspase-3 and inhibition of nuclear factor-kappaB (NF-kappaB) signaling pathway may contribute to the synergistic cytotoxic effect of this combination therapy. hydroxycamptothecinum 83-87 caspase 9 Homo sapiens 160-169 21213403-4 2011 Our results showed that the sensitivity of a combined therapy using triptolide and HCPT was higher than that of triptolide or HCPT alone and that activation of caspase-9/caspase-3 and inhibition of nuclear factor-kappaB (NF-kappaB) signaling pathway may contribute to the synergistic cytotoxic effect of this combination therapy. hydroxycamptothecinum 126-130 caspase 9 Homo sapiens 160-169