PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 14998683-8 2004 To circumvent problems of adduct instability, reactions of [(14)C]CHBrCl(2) with GSH catalyzed by recombinant rat GSTT1-1 were performed in the presence of calf thymus DNA or, alternatively, the model nucleophile deoxyguanosine. Deoxyguanosine 213-227 glutathione S-transferase theta 1 Rattus norvegicus 114-121 14998683-9 2004 Hydroxyapatite chromatography of [(14)C]-labeled DNA or HPLC chromatography of [(14)C]-labeled deoxyguanosine derivatives demonstrated the covalent binding of [(14)C]CHBrCl(2)-derived metabolites to DNA and deoxyguanosine in low yield (approximately 0.02% of [(14)C]CHBrCl(2) biotransformed by GSTT1-1 resulted in DNA adducts). Deoxyguanosine 95-109 glutathione S-transferase theta 1 Rattus norvegicus 294-301