PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
12087347-2	2002	Activation of the renin-angiotensin system by heart failure itself and by nitrate therapy may be one possible mechanism underlying nitrate tolerance.	Nitrates	74-81	renin	Homo sapiens	18-23	
12436367-8	2002	The connection between increased nitric oxide production and the haemodynamic sequelae of portal hypertension is also apparent in the significant correlation between plasma renin and serum nitrate levels.	Nitrates	189-196	renin	Homo sapiens	173-178	
12087347-2	2002	Activation of the renin-angiotensin system by heart failure itself and by nitrate therapy may be one possible mechanism underlying nitrate tolerance.	Nitrates	131-138	renin	Homo sapiens	18-23	
2111676-3	1990	The mechanism of tolerance to nitrates is multifactorial, related on the one hand to depletion of sulfhydryl groups in the body and on the other to activation of the sympathetic and renin-angiotensin systems.	Nitrates	30-38	renin	Homo sapiens	182-187	
10981158-5	2000	All classes of antihypertensive drugs reduce pulse pressure by means of lowering peripheral resistance, but certain drugs like nitrates, angiotensin converting enzyme inhibitors, and other drugs affecting the renin-angiotensin system have multiple actions that improve large artery stiffness and early wave reflection and are especially useful in treating ISH in the elderly.	Nitrates	127-135	renin	Homo sapiens	209-214	
8747803-13	1995	N-acetylcysteine inhibits angiotensin converting enzyme and counteracts nitrate-induced stimulation of the renin angiotensin system in vivo.	Nitrates	72-79	renin	Homo sapiens	107-112	
8225220-6	1993	High serum nitrite/nitrate levels were associated with high plasma renin activity, high aldosterone and antidiuretic hormone levels and low urinary excretion of sodium.	Nitrates	19-26	renin	Homo sapiens	67-72	
11641309-10	2001	Among the antihypertensive agents, nitrates, NO donors, and drugs that interfere with the renin-angiotensin-aldosterone system may offer useful tools to lower pulse pressure, in addition to mean blood pressure.	Nitrates	35-43	renin	Homo sapiens	90-95	
9475262-6	1998	Increases in renin activity amounted to 130% (p < 0.001), 117% (p < 0.001), and 112% (p < 0.001) with molsidomine, and to 14, 16%, and 0 (each NS) with the nitrate at the corresponding times.	Nitrates	165-172	renin	Homo sapiens	13-18