PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 22968712-2 2013 A competitive binding assay using CHO membranes showed that GM (IC(50) = 0.034 muM) more strongly inhibited the binding of the radioligand [(3)H] LSD to 5-HT(7) receptor than the other alkaloids, suggesting that GM is bound to 5-HT(7) receptor. geissoschizine methylether 60-62 latexin Homo sapiens 79-82 22968712-2 2013 A competitive binding assay using CHO membranes showed that GM (IC(50) = 0.034 muM) more strongly inhibited the binding of the radioligand [(3)H] LSD to 5-HT(7) receptor than the other alkaloids, suggesting that GM is bound to 5-HT(7) receptor. geissoschizine methylether 212-214 latexin Homo sapiens 79-82 22968712-3 2013 Agonistic/antagonistic effects of GM (1-50 muM) on the receptor were evaluated by measuring intracellular cAMP levels in HEK239 cells. geissoschizine methylether 34-36 latexin Homo sapiens 43-46 22968712-4 2013 GM (IC(50) = 6.0 muM) inhibited 5-HT-induced cAMP production in a concentration-dependent manner, as well as the specific 5-HT(7) receptor antagonist SB-269970 (0.1-1 muM). geissoschizine methylether 0-2 latexin Homo sapiens 17-20 22968712-4 2013 GM (IC(50) = 6.0 muM) inhibited 5-HT-induced cAMP production in a concentration-dependent manner, as well as the specific 5-HT(7) receptor antagonist SB-269970 (0.1-1 muM). geissoschizine methylether 0-2 latexin Homo sapiens 167-170