PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 29852353-0 2018 Hydrogen gas inhibits lung cancer progression through targeting SMC3. Hydrogen 0-8 structural maintenance of chromosomes 3 Homo sapiens 64-68 29852353-8 2018 Besides, H2 down-regulated the expression of NIBPL, SMC3, SMC5 and SMC6, and also reduced the expression of Cyclin D1, CDK4 and CDK6. Hydrogen 9-11 structural maintenance of chromosomes 3 Homo sapiens 52-56 29852353-9 2018 H2 translocated the subcellular location of SMC3 during cell division and decreased its stability and increased its ubiquitination in both A549 and H1975 cells. Hydrogen 0-2 structural maintenance of chromosomes 3 Homo sapiens 44-48 29852353-10 2018 In addition, inhibition of the proliferation, migration and invasion and promotion of the apoptosis of A549 and H1975 cells induced by H2 were all abolished when overexpressed SMC3 in the presence of H2. Hydrogen 135-137 structural maintenance of chromosomes 3 Homo sapiens 176-180 29852353-10 2018 In addition, inhibition of the proliferation, migration and invasion and promotion of the apoptosis of A549 and H1975 cells induced by H2 were all abolished when overexpressed SMC3 in the presence of H2. Hydrogen 200-202 structural maintenance of chromosomes 3 Homo sapiens 176-180 29852353-13 2018 All data suggested that H2 inhibited lung cancer progression through down-regulating SMC3, a regulator for chromosome condensation, which provided a new method for the treatment of lung cancer. Hydrogen 24-26 structural maintenance of chromosomes 3 Homo sapiens 85-89