PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
22015602-9	2011	In addition, hydrogen decreased malonaldehyde and nitrotyrosine content, inhibited myeloperoxidase and maintained superoxide dismutase activity in lung tissues and associated with a decrease in the expression of TNF-alpha, IL-1beta, IL-6 and total protein concentrations in the BALF.	Hydrogen	13-21	interleukin 6	Mus musculus	233-237	
24116148-6	2013	Compound 1h also reduced secretion of IL-6 and tumor necrosis factor-alpha by LPS-activated J774A.1 murine macrophage cells, primary mice peritoneal macrophages, and JAWSII murine bone marrow-derived dendritic cells and reduced NLRP3 inflammasome-mediated interleukin-1beta (IL-1beta) secretion by LPS + adenosine triphosphate-activated J774A.1 and JAWSII cells.	Hydrogen	9-11	interleukin 6	Mus musculus	38-74	
23742028-6	2013	Hydrogen has been reported to have the ability to inhibit levels of cytokines such as TNF, IL-6 in vivo.	Hydrogen	0-8	interleukin 6	Mus musculus	91-95	
24100894-8	2013	Pretreatment with 10 mumol/L BAY-117082 for 1h significantly inhibited P.e-LPS-induced translocation of NF-kappaB .The mRNA and proteins of IL-6 decreased significantly after pretreatment with 10 mumol/L BAY-117082 and the expression of IL-6 proteins was reduced from (774.983+-6.585) ng/L to (377.384+-14.620) ng/L (P<0.01).	Hydrogen	44-46	interleukin 6	Mus musculus	140-144	
24100894-8	2013	Pretreatment with 10 mumol/L BAY-117082 for 1h significantly inhibited P.e-LPS-induced translocation of NF-kappaB .The mRNA and proteins of IL-6 decreased significantly after pretreatment with 10 mumol/L BAY-117082 and the expression of IL-6 proteins was reduced from (774.983+-6.585) ng/L to (377.384+-14.620) ng/L (P<0.01).	Hydrogen	44-46	interleukin 6	Mus musculus	237-241	
22209213-5	2012	Moreover, ELISA assay revealed that the production of tumor necrosis factor-alpha and interleukin-6 were significantly suppressed by hydrogen in RAW264.7 macrophages, after stimulation with the isolated non-HDL from treated or untreated mice.	Hydrogen	133-141	interleukin 6	Mus musculus	86-99	
23503500-5	2013	In recent years, hydrogen was reported to have an ability to inhibit the levels of cytokines, such as tumor necrosis factor and interleukin-6 in vivo, and it also has a strong selective free radical-scavenging ability.	Hydrogen	17-25	interleukin 6	Mus musculus	128-141	
24008771-4	2013	Hydrogen-rich solution was reported to inhibit the levels of cytokines including INF-gamma, TNF-alpha and IL-6 in vivo in recent studies.	Hydrogen	0-8	interleukin 6	Mus musculus	106-110	
22716165-7	2012	Increased TNFalpha and IL-6 mRNA in the IRI livers was significantly attenuated by H2 S treatment, as was hepatic influx of Ly-6G positive granulocytes.	Hydrogen	83-85	interleukin 6	Mus musculus	23-27	
8307040-1	1994	Two synthetic peptides corresponding to the C-terminal 19 residues of human and murine interleukin-6, respectively, have been synthesized and their structures in solution investigated using high-resolution 1H-NMR spectroscopy.	Hydrogen	206-208	interleukin 6	Mus musculus	87-100	
7599173-1	1995	The effects of solvent, pH and temperature on the 1H-NMR spectra of recombinant murine interleukin-6 (IL-6) are described.	Hydrogen	50-52	interleukin 6	Mus musculus	87-100	
7599173-1	1995	The effects of solvent, pH and temperature on the 1H-NMR spectra of recombinant murine interleukin-6 (IL-6) are described.	Hydrogen	50-52	interleukin 6	Mus musculus	102-106	
20031174-12	2011	In littermate mice, the peak expression levels of TNF-alpha and IL-6 in the liver was observed 1h after PH, which was consistent with data in previous reports.	Hydrogen	95-97	interleukin 6	Mus musculus	64-68	
20816729-8	2010	Expression of pro-inflammatory cytokines (IL-1beta, IL-6, and TNF-alpha) and chemokine (MIP-1alpha) in lung showed an increase from 1h to 24h after instillation and recovered thereafter.	Hydrogen	132-134	interleukin 6	Mus musculus	52-56	
31468277-8	2020	Enzyme-linked immunosorbent assay performed on day 7 revealed that hydrogen water reduced the level of the pro-inflammatory cytokine interleukin-6 and increased that of forkhead box P3 transcription factor, suggesting an enhancement of regulatory T cell activity.	Hydrogen	67-75	interleukin 6	Mus musculus	133-146	
33767697-8	2021	Hydrogen significantly improved the survival rate of mice, reduced pulmonary edema and hemorrhage, infiltration of neutrophils, and IL-6 secretion.	Hydrogen	0-8	interleukin 6	Mus musculus	132-136	
33874887-11	2021	RESULTS: The pancreatic pathological changes, plasma amylase and lipase activity, and the increase of plasma IL-1 and IL-6 levels in AP mice were significantly improved by the hydrogen-rich gases pretreatment, Meanwhile, the pancreatic GSH content increased and the pancreatic MDA content decreased.	Hydrogen	176-184	interleukin 6	Mus musculus	118-122	
32058932-13	2020	In both animal and cell research, hydrogen reduced TNF-alpha, IL-6 and HMGB1 levels and M1 polarization, but increased IL-10 and TGF-beta levels and M2 polarization.	Hydrogen	34-42	interleukin 6	Mus musculus	62-66	
34970349-12	2022	In addition the protein expression levels of RIP1 and RIP3 and the cytokines NF-kappaB, TNF-alpha, IL-1beta and IL-6 were downregulated compared with the TBI group, which demonstrated that hydrogen-rich saline-induced inhibition of necroptosis and neuroinflammation ameliorated neuronal death following TBI.	Hydrogen	189-197	interleukin 6	Mus musculus	112-116	
29921037-6	2018	Meanwhile, H2 inhibited the overexpression of MCP-1, E-selectin, P-selectin and ICAM-1 in oxidant-induced endothelia and reduced inflammatory cells infiltration and proinflammatory cytokines (TNF-alpha, IL-1, IL-6 and IL-8) production in the wound.	Hydrogen	11-13	interleukin 6	Mus musculus	209-213	
30370692-1	2019	Hydrogen sulfide (H2 S) has a significant effect on the regulation of interleukin-6 (IL-6) and signal transducer and activator of transcription 3 (STAT3) activities, while IL-6 directly regulates hepcidin expression via STAT3.	Hydrogen	18-20	interleukin 6	Mus musculus	70-83	
30370692-1	2019	Hydrogen sulfide (H2 S) has a significant effect on the regulation of interleukin-6 (IL-6) and signal transducer and activator of transcription 3 (STAT3) activities, while IL-6 directly regulates hepcidin expression via STAT3.	Hydrogen	18-20	interleukin 6	Mus musculus	85-89	
29166710-16	2017	(2) At PIH 24, the content of HMGB1 and IL-6 in serum and lung tissue of mice in hydrogen group was close to that in sham injury group (with P values above 0.05).	Hydrogen	81-89	interleukin 6	Mus musculus	40-44	
29166710-18	2017	The content of HMGB1 and IL-6 in serum and lung tissue of mice in burn+ hydrogen group was significantly lower than that in pure burn group (with P values below 0.001).	Hydrogen	72-80	interleukin 6	Mus musculus	25-29	
28852144-6	2017	ELISA analyses showed that inhalation of hydrogen-oxygen mixed gas blocked CMS-induced increase in the serum levels of corticosterone, adrenocorticotropic hormone, interleukin-6, and tumor necrosis factor-alpha in mice exposed to chronic mild stress.	Hydrogen	41-49	interleukin 6	Mus musculus	164-210