PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
29852353-8	2018	Besides, H2 down-regulated the expression of NIBPL, SMC3, SMC5 and SMC6, and also reduced the expression of Cyclin D1, CDK4 and CDK6.	Hydrogen	9-11	cyclin dependent kinase 6	Homo sapiens	128-132	
31875784-7	2019	RESULTS: Abemaciclib showed the greatest tendency to bind CDK-6 via binding 16 residues in the binding site with hydrogen bonds and hydrophobic bonding.	Hydrogen	113-121	cyclin dependent kinase 6	Homo sapiens	58-63	
28168755-0	2017	Palbociclib can overcome mutations in cyclin dependent kinase 6 that break hydrogen bonds between the drug and the protein.	Hydrogen	75-83	cyclin dependent kinase 6	Homo sapiens	38-63	
22172011-6	2012	Besides the electrostatic interactions, especially through hydrogen bond formation, the van der Waals (vdW) interactions with the I19, V27, F98, H100, and L152 residues of CDK6 are also important factors in the binding efficiency of flavonoids against the CDK6/cycD complex.	Hydrogen	59-67	cyclin dependent kinase 6	Homo sapiens	172-176	
15689157-6	2005	Fisetin binds to the active form of CDK6, forming hydrogen bonds with the side chains of residues in the binding pocket that undergo large conformational changes during CDK activation by cyclin binding.	Hydrogen	50-58	cyclin dependent kinase 6	Homo sapiens	36-40	
18573309-9	2008	This is due to ten hydrogen bonds and eight salt bridges which exist between the native type and cdk6, whereas the mutant type makes only nine hydrogen bonds and five salt bridges with cdk6.	Hydrogen	19-27	cyclin dependent kinase 6	Homo sapiens	97-101