PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
30791611-3	2019	The aim of this study was to determine whether metabolic reprogramming associated with IDH mutant gliomas leads to additional 1H MRS-detectable differences between IDH1 and IDH2 mutations, and to identify metabolites correlated with 2-HG.	Hydrogen	126-128	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	87-90	
33668509-5	2021	In this study we used high resolution 1H magnetic resonance spectroscopy (1H-MRS) to identify early noninvasive MR (Magnetic Resonance)-detectable metabolic biomarkers of response to mutant IDH inhibition.	Hydrogen	38-40	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	190-193	
33668509-5	2021	In this study we used high resolution 1H magnetic resonance spectroscopy (1H-MRS) to identify early noninvasive MR (Magnetic Resonance)-detectable metabolic biomarkers of response to mutant IDH inhibition.	Hydrogen	74-76	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	190-193	
33212941-0	2020	Non-Invasive Prediction of IDH Mutation in Patients with Glioma WHO II/III/IV Based on F-18-FET PET-Guided In Vivo 1H-Magnetic Resonance Spectroscopy and Machine Learning.	Hydrogen	115-117	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	27-30	
33212941-5	2020	Therefore, we explored the use of machine learning for the non-invasive, inexpensive and fast diagnosis of IDH status in standard 1H-magnetic resonance spectroscopy (1H-MRS).	Hydrogen	130-132	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	107-110	
33212941-5	2020	Therefore, we explored the use of machine learning for the non-invasive, inexpensive and fast diagnosis of IDH status in standard 1H-magnetic resonance spectroscopy (1H-MRS).	Hydrogen	166-168	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	107-110	
30791611-3	2019	The aim of this study was to determine whether metabolic reprogramming associated with IDH mutant gliomas leads to additional 1H MRS-detectable differences between IDH1 and IDH2 mutations, and to identify metabolites correlated with 2-HG.	Hydrogen	126-128	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	164-168	
27587950-1	2016	The diagnostic and prognostic potential of an onco-metabolite, 2-hydroxyglutarate (2HG) as a proton magnetic resonance spectroscopy (1H-MRS) detectable biomarker of the isocitrate dehydrogenase (IDH)-mutated (IDH-MT) gliomas has drawn attention of neuroradiologists recently.	Hydrogen	133-135	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	169-193	
22040412-8	2011	IDH1 changes of binding free energy (DeltaE) suggested that the A132Arg residue from chain A contributes three hydrogen bonds to the ICT alpha-carboxyl and beta-carboxyl groups, while the other nine residues involved in ICT binding form only one or two hydrogen bonds.	Hydrogen	111-119	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	0-4	
22040412-8	2011	IDH1 changes of binding free energy (DeltaE) suggested that the A132Arg residue from chain A contributes three hydrogen bonds to the ICT alpha-carboxyl and beta-carboxyl groups, while the other nine residues involved in ICT binding form only one or two hydrogen bonds.	Hydrogen	253-261	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	0-4	
34557149-1	2021	The onco-metabolite 2-hydroxyglutarate (2HG), a biomarker of IDH-mutant gliomas, can be detected with 1H MR spectroscopy (1H-MRS).	Hydrogen	102-104	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	61-64	
34557149-1	2021	The onco-metabolite 2-hydroxyglutarate (2HG), a biomarker of IDH-mutant gliomas, can be detected with 1H MR spectroscopy (1H-MRS).	Hydrogen	122-124	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	61-64	
35002404-7	2022	Screening of 5000+ compounds filtered two efficacious compounds (Artocarpetin and 5-Galloylquinic acid) capable of establishing hydrogen bond connections with both IDH variants.	Hydrogen	128-136	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	164-167