PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
9790931-6	1998	This increased viability of the transfected cells was blocked by CA074, a specific inhibitor of cathepsin B, while pepstatin A suppressed the action of CA074.	N-(3-propylcarbamoyloxirane-2-carbonyl)-isoleucyl-proline	65-70	cathepsin B	Rattus norvegicus	96-107	
10336074-3	1999	In a culture of PC12 cells treated with acetyl-DEVD-cho, where caspase-3-like proteinases are not activated, CA074, a specific inhibitor of cathepsin B induced active death of the cells.	N-(3-propylcarbamoyloxirane-2-carbonyl)-isoleucyl-proline	109-114	cathepsin B	Rattus norvegicus	140-151	
10336074-4	1999	Cathepsin B antisense oligonucleotides showed a similar effect to CA074 on the induction of active cell death.	N-(3-propylcarbamoyloxirane-2-carbonyl)-isoleucyl-proline	66-71	cathepsin B	Rattus norvegicus	0-11	
9540855-8	1997	The cathepsin B inhibitor CA-074 prevented neither the caerulein-induced formation of TAP nor the (CBZ-Arg)2-Rho 110-cleaving activity.	N-(3-propylcarbamoyloxirane-2-carbonyl)-isoleucyl-proline	26-32	cathepsin B	Rattus norvegicus	4-15	
1715285-2	1991	Administration of compound CA-074 or pepstatinasialofetuin to rats caused only a slight shift of the lysosomal density and no increase in sequestered enzymes in the autolysosomal fraction, although cathepsin B or D activity in the liver was markedly inhibited.	N-(3-propylcarbamoyloxirane-2-carbonyl)-isoleucyl-proline	27-33	cathepsin B	Rattus norvegicus	198-209	
31973644-9	2020	Addition of CA-074, a cathepsin B specific, inhibitor confirmed that protease activity was due to active matCatB in rat brain tissues and CSF at all time points.	N-(3-propylcarbamoyloxirane-2-carbonyl)-isoleucyl-proline	12-18	cathepsin B	Rattus norvegicus	22-33	
26562519-2	2016	In this hypothesis, the release of cathepsin-B due to a change of lysosomal membrane permeabilization (LMP) or rupture is critical, and this can be prevented by its inhibitors CA074 and CA074-me.	N-(3-propylcarbamoyloxirane-2-carbonyl)-isoleucyl-proline	176-181	cathepsin B	Rattus norvegicus	35-46	
18638529-8	2008	The coadministration of CA074, an irreversible CB inhibitor, with MeHg significantly reduced the severity of pyknotic changes of the granule cells.	N-(3-propylcarbamoyloxirane-2-carbonyl)-isoleucyl-proline	24-29	cathepsin B	Rattus norvegicus	47-49	
12421595-10	2003	Pepstatin A and CA074 Me inhibited cathepsin B and cathepsin D activities, respectively, in the presence and absence of Ac-DMQD-CHO.	N-(3-propylcarbamoyloxirane-2-carbonyl)-isoleucyl-proline	16-21	cathepsin B	Rattus norvegicus	35-46	
1382984-6	1992	Under the marked inhibition of general lysosomal cysteine-proteinase activity by E-64-c or marked selective inhibition of cathepsin-B activity by CA-074 in vitro, degradation of FITC-labeled asialofetuin by disrupted lysosomes was analyzed on the basis of measurement of FITC-labeled degradation products by Sephadex G-25 column chromatography.	N-(3-propylcarbamoyloxirane-2-carbonyl)-isoleucyl-proline	146-152	cathepsin B	Rattus norvegicus	122-133