PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
27806917-0	2016	Clonidine preconditioning alleviated focal cerebral ischemic insult in rats via up-regulating p-NMDAR1 and down-regulating NMDAR2A / p-NMDAR2B.	Clonidine	0-9	glutamate ionotropic receptor NMDA type subunit 1	Rattus norvegicus	96-102	
27806917-8	2016	Remarkably, clonidine treatment led to significant down-regulation of p-NMDAR2B and NMDAR2A in addition to enhancement of the expression level of p-NMDAR1 in cortex.	Clonidine	12-21	glutamate ionotropic receptor NMDA type subunit 1	Rattus norvegicus	148-154	
27806917-9	2016	This is the first report illustrating the neuroprotective role of clonidine may be mediated through modulation of the expression levels of p-NMDAR2B, NMDAR2A and p-NMDAR1 during cerebral ischemia.	Clonidine	66-75	glutamate ionotropic receptor NMDA type subunit 1	Rattus norvegicus	164-170	
18633054-0	2008	Intrathecal clonidine suppresses phosphorylation of the N-methyl-D-aspartate receptor NR1 subunit in spinal dorsal horn neurons of rats with neuropathic pain.	Clonidine	12-21	glutamate ionotropic receptor NMDA type subunit 1	Rattus norvegicus	86-89	
20007733-1	2010	BACKGROUND: A previous study from our laboratories showed that a significant reduction in spinal N-methyl-D-aspartate (NMDA) receptor NR1 subunit phosphorylation (pNR1) is associated with the antiallodynic effect produced by intrathecal (IT) injection of the alpha-2 adrenoceptor agonist, clonidine, in neuropathic rats.	Clonidine	289-298	glutamate ionotropic receptor NMDA type subunit 1	Rattus norvegicus	134-137	
20007733-10	2010	Furthermore, these findings suggest that the modulation of spinal NR1 phosphorylation is linked to the effect of IT clonidine on postsynaptic neuronal activity.	Clonidine	116-125	glutamate ionotropic receptor NMDA type subunit 1	Rattus norvegicus	66-69	
18633054-9	2008	In addition, IT injection of the alpha-2 adrenoceptor antagonist, idazoxan (40 microg/rat) 10 min before clonidine injection completely reversed clonidine"s antihyperalgesic and antiallodynic effects, as well as clonidine"s suppressive effect on CCI-induced NR1 phosphorylation in the spinal cord dorsal horn.	Clonidine	145-154	glutamate ionotropic receptor NMDA type subunit 1	Rattus norvegicus	258-261	
18633054-9	2008	In addition, IT injection of the alpha-2 adrenoceptor antagonist, idazoxan (40 microg/rat) 10 min before clonidine injection completely reversed clonidine"s antihyperalgesic and antiallodynic effects, as well as clonidine"s suppressive effect on CCI-induced NR1 phosphorylation in the spinal cord dorsal horn.	Clonidine	145-154	glutamate ionotropic receptor NMDA type subunit 1	Rattus norvegicus	258-261