PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
14499442-7	2003	Peri-neural clonidine reduced the increase in tissue content of the proinflammatory cytokines IL-1beta and particularly TNFalpha in sciatic nerve, DRG and spinal cord while increasing concentrations of the anti-inflammatory cytokine TGF-beta1.	Clonidine	12-21	tumor necrosis factor	Rattus norvegicus	120-128	
28666582-8	2017	Clonidine decreased HMGB1 and TNF-alpha expression following LCHS/CS (22%* and 58%*, respectively.)	Clonidine	0-9	tumor necrosis factor	Rattus norvegicus	30-39	
16192389-10	2005	Clonidine reduced the number of macrophages and lymphocytes as well as their expression of tumor necrosis factor alpha.	Clonidine	0-9	tumor necrosis factor	Rattus norvegicus	91-118	
29452086-14	2018	Moreover, clonidine reduced renal tumor necrosis factor-alpha (inflammatory marker) and caspase-3 (apoptotic marker) levels, while increased renal prostaglandine E2 and interleukin-10 levels (anti-inflammatory markers).	Clonidine	10-19	tumor necrosis factor	Rattus norvegicus	34-61	
14499442-8	2003	Clonidine"s effects on behavior and TNFalpha content were blocked by BRL44408.	Clonidine	0-9	tumor necrosis factor	Rattus norvegicus	36-44	
11476962-7	2001	The results indicate that both NE and clonidine increased TNF-alpha release by approximately 4-7-fold in the isolated cultured Kupffer cells.	Clonidine	38-47	tumor necrosis factor	Rattus norvegicus	58-67	
10808050-5	2000	Administration to rats of an alpha(2)-adrenergic receptor agonist (clonidine) decreases levels of TNF in homogenates of rat locus coeruleus and hippocampus within 7.5 min.	Clonidine	67-76	tumor necrosis factor	Rattus norvegicus	98-101	
8862135-6	1996	Furthermore, constitutive TNF alpha, demonstrated to be present in several brain areas, was significantly decreased following administration of the alpha 2-adrenergic agonist clonidine (0.6 mg/kg, i.p., twice daily) to rats for either 1 or 14 days, without a change in TNF alpha mRNA accumulation.	Clonidine	175-184	tumor necrosis factor	Rattus norvegicus	26-35	
8862135-6	1996	Furthermore, constitutive TNF alpha, demonstrated to be present in several brain areas, was significantly decreased following administration of the alpha 2-adrenergic agonist clonidine (0.6 mg/kg, i.p., twice daily) to rats for either 1 or 14 days, without a change in TNF alpha mRNA accumulation.	Clonidine	175-184	tumor necrosis factor	Rattus norvegicus	269-278	
8862135-7	1996	We next investigated whether the presynaptic sensitivity to TNF alpha was changed after clonidine administration to rats.	Clonidine	88-97	tumor necrosis factor	Rattus norvegicus	60-69	
8862135-8	1996	TNF alpha enhanced, rather than inhibited, [3H]-NE release after 1 day of clonidine administration, while a suppressed sensitivity to TNF alpha was observed in the hippocampus after 14 days of clonidine administration.	Clonidine	74-83	tumor necrosis factor	Rattus norvegicus	0-9	
8862135-8	1996	TNF alpha enhanced, rather than inhibited, [3H]-NE release after 1 day of clonidine administration, while a suppressed sensitivity to TNF alpha was observed in the hippocampus after 14 days of clonidine administration.	Clonidine	193-202	tumor necrosis factor	Rattus norvegicus	134-143	
8862135-9	1996	In addition, in the presence of idazoxan, TNF alpha potentiation of [3H]-NE release after 1 day clonidine administration was reversed to a decreased inhibition as compared to control slices exposed to idazoxan.	Clonidine	96-105	tumor necrosis factor	Rattus norvegicus	42-51	
8862135-10	1996	Therefore, the temporary reversal in the presynaptic TNF alpha response after 1 day of clonidine administration illustrates a mechanism of action for its persistent antihypertensive effect, its transient sedative and antihyperpathic effects, and its acute ability to promote antidepressants.	Clonidine	87-96	tumor necrosis factor	Rattus norvegicus	53-62	
8862135-0	1996	Changes in noradrenergic sensitivity to tumor necrosis factor-alpha in brains of rats administered clonidine.	Clonidine	99-108	tumor necrosis factor	Rattus norvegicus	40-67