PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 2856056-0 1988 Inhibition of serotonin-induced ACTH release in man by clonidine. Clonidine 55-64 proopiomelanocortin Homo sapiens 32-36 2856056-6 1988 The present study investigated the effect of clonidine on fenfluramine-induced ACTH release in six normal volunteers. Clonidine 45-54 proopiomelanocortin Homo sapiens 79-83 2856056-10 1988 The mean plasma ACTH and cortisol levels and the mean maximal changes in these levels were significantly lower during the clonidine + fenfluramine test than during fenfluramine alone. Clonidine 122-131 proopiomelanocortin Homo sapiens 16-20 2856056-13 1988 In conclusion, clonidine blocked the ACTH-releasing activity of fenfluramine in normal humans. Clonidine 15-24 proopiomelanocortin Homo sapiens 37-41 2856056-14 1988 This inhibition of active ACTH release may result from clonidine blockade of fenfluramine-induced activation of central NNA. Clonidine 55-64 proopiomelanocortin Homo sapiens 26-30 2856056-15 1988 Clonidine alone was no more effective than placebo in lowering plasma ACTH and cortisol. Clonidine 0-9 proopiomelanocortin Homo sapiens 70-74 2847928-1 1988 The role of alpha 2-adrenoceptor stimulation by clonidine on the secretion of beta-endorphin, ACTH, and cortisol in essential hypertension and obesity was studied in 45 subjects: 15 non-obese hypertensives, 10 obese hypertensives, 11 obese normotensives, and 9 healthy subjects. Clonidine 48-57 proopiomelanocortin Homo sapiens 78-92 2847928-3 1988 Clonidine lowered the blood pressure and blood ACTH and cortisol levels in all the subjects. Clonidine 0-9 proopiomelanocortin Homo sapiens 47-51 2847928-4 1988 A significant decrease in beta-endorphin after clonidine occurred in the healthy subjects. Clonidine 47-56 proopiomelanocortin Homo sapiens 26-40 2847928-6 1988 In about 50% of non-obese and obese hypertensives a significant increase in beta-endorphin secretion after clonidine was noted (responders). Clonidine 107-116 proopiomelanocortin Homo sapiens 76-90 2945042-0 1986 Clonidine normalizes low plasma beta-endorphin concentration and blood pressure in young men with mild essential hypertension. Clonidine 0-9 proopiomelanocortin Homo sapiens 32-46 2889310-5 1987 However, a marked increase in beta-endorphin was observed in obese patients after clonidine administration. Clonidine 82-91 proopiomelanocortin Homo sapiens 30-44 2455169-0 1987 Normalization of blood pressure and plasma concentrations of beta-endorphin and leucine-enkephalin in patients with primary hypertension after treatment with clonidine. Clonidine 158-167 proopiomelanocortin Homo sapiens 61-75 2455169-4 1987 After 14 days of treatment with clonidine, which decreases sympathetic activity via a central action, beta-endorphin, leucine-enkephalin, and noradrenaline concentrations did not differ between both groups. Clonidine 32-41 proopiomelanocortin Homo sapiens 102-116 2455169-6 1987 Besides via sympathetic inhibition, clonidine also may reduce the increased blood pressure further by normalizing central beta-endorphin release. Clonidine 36-45 proopiomelanocortin Homo sapiens 122-136 2455186-4 1987 A significant increase in GH and a significant decrease in ACTH and in cortisol was observed after clonidine injection in healthy women. Clonidine 99-108 proopiomelanocortin Homo sapiens 59-63 2455186-7 1987 In Cushing"s disease, ACTH significantly decreased in response to clonidine. Clonidine 66-75 proopiomelanocortin Homo sapiens 22-26 2455186-9 1987 Conclusions are as follows: (1) Clonidine may be useful in the treatment of hypertensive menopausal women; and (2) a diminution in ACTH, beta-endorphin, and cortisol release in response to clonidine was observed in Cushing"s disease. Clonidine 189-198 proopiomelanocortin Homo sapiens 131-135 2455186-9 1987 Conclusions are as follows: (1) Clonidine may be useful in the treatment of hypertensive menopausal women; and (2) a diminution in ACTH, beta-endorphin, and cortisol release in response to clonidine was observed in Cushing"s disease. Clonidine 189-198 proopiomelanocortin Homo sapiens 137-151 2995746-0 1985 Central alpha-activation by clonidine reduces plasma level of beta-endorphin in patients with essential hypertension. Clonidine 28-37 proopiomelanocortin Homo sapiens 62-76 2951760-0 1987 Clonidine stimulation in anorexia nervosa: growth hormone, cortisol, and beta-endorphin responses. Clonidine 0-9 proopiomelanocortin Homo sapiens 73-87 2934351-0 1985 Comparison of the effect of insulin hypoglycemia and clonidine on secretion of growth hormone, cortisol and beta-endorphin in children and adolescents. Clonidine 53-62 proopiomelanocortin Homo sapiens 108-122 2934351-3 1985 Whereas hypoglycemia raised plasma beta-endorphin levels, clonidine slightly decreased beta-endorphin in six subjects and had no effect in four. Clonidine 58-67 proopiomelanocortin Homo sapiens 87-101 2995746-1 1985 Whether peripheral beta-endorphin contributes to the antihypertensive action of clonidine was examined by measuring plasma levels of beta-endorphin-like immunoreactivity (beta EpLI) after acute administration of clonidine in patients with essential hypertension. Clonidine 80-89 proopiomelanocortin Homo sapiens 19-33 2995746-2 1985 Administration of clonidine (0.225 mg) in one dose significantly lowered blood pressure, decreased heart rate and reduced the plasma level of beta EpLI and ACTH, while the placebo had no effect on blood pressure, heart rate or plasma level of beta EpLI suggesting that peripheral beta-endorphin does not play a major role in the antihypertensive action of acute clonidine administration. Clonidine 18-27 proopiomelanocortin Homo sapiens 280-294 2857510-4 1985 In the controls, clonidine induced release of beta-LPH and beta-EP after 30 min (from 8.9 +/- 1.0 to 19.1 +/- 4.6 fmol/ml, P less than 0.01 and from 8.1 +/- 0.6 to 17.9 +/- 4.6, P less than 0.01) and of ACTH after 60 min (from 12.1 +/- 1.8 to 18.1 +/- 1.8, P less than 0.05) while in addicts beta-EP but not beta-LPH showed a significant increase (from 8.5 +/- 0.7 to 19.8 +/- 4.2, P less than 0.05), 90 min after the injection. Clonidine 17-26 proopiomelanocortin Homo sapiens 46-54 2857510-4 1985 In the controls, clonidine induced release of beta-LPH and beta-EP after 30 min (from 8.9 +/- 1.0 to 19.1 +/- 4.6 fmol/ml, P less than 0.01 and from 8.1 +/- 0.6 to 17.9 +/- 4.6, P less than 0.01) and of ACTH after 60 min (from 12.1 +/- 1.8 to 18.1 +/- 1.8, P less than 0.05) while in addicts beta-EP but not beta-LPH showed a significant increase (from 8.5 +/- 0.7 to 19.8 +/- 4.2, P less than 0.05), 90 min after the injection. Clonidine 17-26 proopiomelanocortin Homo sapiens 59-66 2857510-4 1985 In the controls, clonidine induced release of beta-LPH and beta-EP after 30 min (from 8.9 +/- 1.0 to 19.1 +/- 4.6 fmol/ml, P less than 0.01 and from 8.1 +/- 0.6 to 17.9 +/- 4.6, P less than 0.01) and of ACTH after 60 min (from 12.1 +/- 1.8 to 18.1 +/- 1.8, P less than 0.05) while in addicts beta-EP but not beta-LPH showed a significant increase (from 8.5 +/- 0.7 to 19.8 +/- 4.2, P less than 0.05), 90 min after the injection. Clonidine 17-26 proopiomelanocortin Homo sapiens 203-207 2857510-4 1985 In the controls, clonidine induced release of beta-LPH and beta-EP after 30 min (from 8.9 +/- 1.0 to 19.1 +/- 4.6 fmol/ml, P less than 0.01 and from 8.1 +/- 0.6 to 17.9 +/- 4.6, P less than 0.01) and of ACTH after 60 min (from 12.1 +/- 1.8 to 18.1 +/- 1.8, P less than 0.05) while in addicts beta-EP but not beta-LPH showed a significant increase (from 8.5 +/- 0.7 to 19.8 +/- 4.2, P less than 0.05), 90 min after the injection. Clonidine 17-26 proopiomelanocortin Homo sapiens 292-299 2857510-4 1985 In the controls, clonidine induced release of beta-LPH and beta-EP after 30 min (from 8.9 +/- 1.0 to 19.1 +/- 4.6 fmol/ml, P less than 0.01 and from 8.1 +/- 0.6 to 17.9 +/- 4.6, P less than 0.01) and of ACTH after 60 min (from 12.1 +/- 1.8 to 18.1 +/- 1.8, P less than 0.05) while in addicts beta-EP but not beta-LPH showed a significant increase (from 8.5 +/- 0.7 to 19.8 +/- 4.2, P less than 0.05), 90 min after the injection. Clonidine 17-26 proopiomelanocortin Homo sapiens 308-316 2857510-7 1985 Clonidine-induced release of plasma beta-EP may be of importance with regard to its therapeutic effects in detoxification. Clonidine 0-9 proopiomelanocortin Homo sapiens 36-43 3157294-0 1985 beta-Endorphin and essential hypertension: importance of the clonidine-naloxone interaction. Clonidine 61-70 proopiomelanocortin Homo sapiens 0-14 6089027-0 1984 Beta-endorphin contributes to the antihypertensive effect of clonidine in a subset of patients with essential hypertension. Clonidine 61-70 proopiomelanocortin Homo sapiens 0-14 3160633-0 1985 Beta-endorphin: a common factor in the antihypertensive action of clonidine-type imidazolines in spontaneously hypertensive rats. Clonidine 66-75 proopiomelanocortin Homo sapiens 0-14 2860247-3 1985 The longlasting signal generated by the covalent MSH-receptor complex was readily and reversibly abolished by adrenaline, noradrenaline, dopamine or clonidine or by the absence of calcium. Clonidine 149-158 proopiomelanocortin Homo sapiens 49-52 6097932-3 1984 The peak increments in levels of plasma growth hormone (GH) and beta-endorphin induced by clonidine did not differ between heroin addicts and normal control subjects. Clonidine 90-99 proopiomelanocortin Homo sapiens 64-78 6094329-0 1984 Effect of clonidine on ACTH and cortisol release induced by cigarette smoking in man. Clonidine 10-19 proopiomelanocortin Homo sapiens 23-27 6089027-3 1984 Clonidine increased plasma beta-endorphin concentration of the reacting patients by 17.53 +/- 1.68 pM/1 and in the non-reacting ones by 5.91 +/- 0.88 pM/1. Clonidine 0-9 proopiomelanocortin Homo sapiens 27-41 6089027-4 1984 Significant linear correlation was found between the clonidine-induced increase in plasma beta-endorphin level and the naloxone-induced change in mean blood pressure [r = 0.9572, n:24, p less than 0.001]. Clonidine 53-62 proopiomelanocortin Homo sapiens 90-104 6316231-0 1983 [The role of beta endorphin in the antihypertensive action of clonidine, associated with sympathetic tonus decrease, in essential hypertension]. Clonidine 62-71 proopiomelanocortin Homo sapiens 13-27 6314685-4 1983 Clonidine clearly reduced plasma ACTH, serum cortisol and renin activity. Clonidine 0-9 proopiomelanocortin Homo sapiens 33-37 6302442-0 1983 Decreased secretion of cortisol and ACTH after oral clonidine administration in normal adults. Clonidine 52-61 proopiomelanocortin Homo sapiens 36-40 6302442-3 1983 The effect of clonidine upon ACTH and cortisol levels is not as clear, and both stimulatory and inhibitory effects have been reported. Clonidine 14-23 proopiomelanocortin Homo sapiens 29-33 6300170-2 1983 Clonidine (300 micrograms daily) significantly increased plasma beta endorphin concentrations only in the hypertensive patients. Clonidine 0-9 proopiomelanocortin Homo sapiens 64-78 6300170-3 1983 The significant linear correlation between the increase in plasma beta endorphin concentration and the decrease in blood pressure (both systolic and diastolic) in these patients may point to the role of this endogenous opioid in the antihypertensive action of clonidine. Clonidine 260-269 proopiomelanocortin Homo sapiens 66-80 10825337-0 2000 The effect of clonidine pretreatment on the perioperative proinflammatory cytokines, cortisol, and ACTH responses in patients undergoing total abdominal hysterectomy. Clonidine 14-23 proopiomelanocortin Homo sapiens 99-103 10949540-0 2000 Effect of clonidine on plasma ACTH, cortisol and melatonin in children. Clonidine 10-19 proopiomelanocortin Homo sapiens 30-34 10949540-9 2000 The results show a significant decrease in plasma ACTH, cortisol and melatonin 30 min after clonidine administration (P < 0.001), reaching lowest values at 90 min after the drug was administered. Clonidine 92-101 proopiomelanocortin Homo sapiens 50-54 10825337-1 2000 UNLABELLED: We investigated the hypothesis that oral clonidine premedication would decrease the release of proinflammatory cytokines interleukin (IL)-6, IL-1beta, and tumor necrosis factor-alpha, and stress hormones cortisol and adrenocorticotropic hormone (ACTH), in patients who underwent total abdominal hysterectomy. Clonidine 53-62 proopiomelanocortin Homo sapiens 229-256 10825337-1 2000 UNLABELLED: We investigated the hypothesis that oral clonidine premedication would decrease the release of proinflammatory cytokines interleukin (IL)-6, IL-1beta, and tumor necrosis factor-alpha, and stress hormones cortisol and adrenocorticotropic hormone (ACTH), in patients who underwent total abdominal hysterectomy. Clonidine 53-62 proopiomelanocortin Homo sapiens 258-262 10825337-6 2000 In the comparison study between the control group and the clonidine group, there was a significant decrease in IL-6 level 3 h after the start of surgery and IL-1beta at preinduction time in the clonidine group, whereas there were no changes in tumor necrosis factor-alpha, cortisol, and ACTH levels. Clonidine 58-67 proopiomelanocortin Homo sapiens 287-291 10825337-6 2000 In the comparison study between the control group and the clonidine group, there was a significant decrease in IL-6 level 3 h after the start of surgery and IL-1beta at preinduction time in the clonidine group, whereas there were no changes in tumor necrosis factor-alpha, cortisol, and ACTH levels. Clonidine 194-203 proopiomelanocortin Homo sapiens 287-291 9335081-7 1997 After CCK-4, in the clonidine condition the pituitary release of adrenocorticotropin (ACTH) and prolactin was seemingly enhanced compared to placebo. Clonidine 20-29 proopiomelanocortin Homo sapiens 86-90 9810488-0 1998 Modifications in the distribution of met-enkephalin in the cat spinal cord after administration of clonidine. Clonidine 99-108 proopiomelanocortin Homo sapiens 37-51 9810488-4 1998 However, after intravenous or intrathecal administration of clonidine a decrease in fibers containing met-enkephalin was observed in layers I and II (high or moderate density), the dorso-lateral funiculus, and the reticular formation (moderate or low density), and in layers IV and V (low or very low density). Clonidine 60-69 proopiomelanocortin Homo sapiens 102-116 9810488-6 1998 Our results suggest that clonidine induces the release of metenkephalin in the spinal cord. Clonidine 25-34 proopiomelanocortin Homo sapiens 58-71 9690117-0 1998 Modifications in the distribution of met-enkephalin in the pons of the cat, following the intravenous administration of clonidine: an immunocytochemical experimental study. Clonidine 120-129 proopiomelanocortin Homo sapiens 37-51 9690117-1 1998 The distribution of met-enkephalin in the cat and its modifications following the stimulation by intravenous clonidine, was studied with indirect immunocytochemical techniques. Clonidine 109-118 proopiomelanocortin Homo sapiens 20-34 9571601-7 1998 The clonidine test induced a significant increase of plasma beta-EP levels in women after receiving DHEA supplementation but not before; conversely, plasma GM levels increased both before and after treatment. Clonidine 4-13 proopiomelanocortin Homo sapiens 60-67 9571601-8 1998 CONCLUSIONS: The present study indicates that short-term DHEA supplementation in postmenopausal women is able to restore the impaired response of pituitary beta-EP to clonidine, an alpha 2 presinaptic agonist. Clonidine 167-176 proopiomelanocortin Homo sapiens 156-163 8586472-5 1995 After 150 min and 14 days of treatment with clonidine, plasma levels of beta-endorphin, leucine-enkephalin increased significantly (< 0.01) and correlated negatively with the decrease of the mean artery pressure (r = -0.340 and r = -0.436 at 150 min, r = -0.369 and r = -0.441 on the 14th day, respectively, P < 0.01). Clonidine 44-53 proopiomelanocortin Homo sapiens 72-86 8243225-7 1993 These data suggest that beta-EP and LEK may be involved in pathogenesis of hypertension and in hypotensive action of clonidine. Clonidine 117-126 proopiomelanocortin Homo sapiens 24-31 7969853-1 1994 Growth hormone (GH) and beta-endorphin (beta-EP) responses to clonidine stimulation were examined in 18 male heroin addicts, 9 with and 9 without previous histories of attention deficit disorder with hyperactivity (ADD-H) and conduct disorder (CD). Clonidine 62-71 proopiomelanocortin Homo sapiens 24-38 7969853-1 1994 Growth hormone (GH) and beta-endorphin (beta-EP) responses to clonidine stimulation were examined in 18 male heroin addicts, 9 with and 9 without previous histories of attention deficit disorder with hyperactivity (ADD-H) and conduct disorder (CD). Clonidine 62-71 proopiomelanocortin Homo sapiens 40-47 7831997-3 1994 The GH and beta-endorphin responses to clonidine were blunted in group A subjects compared with controls and normal in group B. Clonidine 39-48 proopiomelanocortin Homo sapiens 11-25 1763654-1 1991 The central alpha-2-adrenergic receptor agonist, clonidine (300 micrograms daily) significantly increased the plasma beta-endorphin-like immunoreactivity (beta ELI) in 12 patients with mild to moderate essential hypertension in a randomized, crossover study. Clonidine 49-58 proopiomelanocortin Homo sapiens 117-131 8231651-0 1993 Clonidine lowers alpha-MSH-like immunoreactivity in human plasma. Clonidine 0-9 proopiomelanocortin Homo sapiens 17-26 8231651-1 1993 In a group of seven healthy subjects, the effects of acute intravenous administration of clonidine, a selective alpha 2 receptor stimulator, on plasma alpha-MSH-LI concentrations were measured. Clonidine 89-98 proopiomelanocortin Homo sapiens 151-160 8231651-2 1993 In comparison with saline, clonidine (0.075 mg) significantly reduced alpha-MSH-LI concentrations, with a maximum fall between 30 and 60 min., followed by a return to basal concentrations at 120 min. Clonidine 27-36 proopiomelanocortin Homo sapiens 70-79 2129311-4 1990 The response of beta-endorphin to clonidine in the AN patients was increased, whereas the response of beta-endorphin to naloxone was decreased. Clonidine 34-43 proopiomelanocortin Homo sapiens 16-30 2140250-0 1990 Effects of intramuscular clonidine on hemodynamic and plasma beta-endorphin responses to gynecologic laparoscopy. Clonidine 25-34 proopiomelanocortin Homo sapiens 61-75 2140250-10 1990 The blunting effect of clonidine on hemodynamics and plasma beta endorphin may reflect a deeper level of anesthesia in those women receiving clonidine as preanesthetic medication or can be explained by an interaction of clonidine with endogenous opiates. Clonidine 23-32 proopiomelanocortin Homo sapiens 60-74 2160341-0 1990 Naloxone-induced ACTH release in man is inhibited by clonidine. Clonidine 53-62 proopiomelanocortin Homo sapiens 17-21 2160341-3 1990 We used the alpha 2-adrenergic agonist, clonidine, as a central nervous system inhibitor of ACTH release to see if it would alter naloxone-induced ACTH secretion in normal human volunteers. Clonidine 40-49 proopiomelanocortin Homo sapiens 92-96 2160341-3 1990 We used the alpha 2-adrenergic agonist, clonidine, as a central nervous system inhibitor of ACTH release to see if it would alter naloxone-induced ACTH secretion in normal human volunteers. Clonidine 40-49 proopiomelanocortin Homo sapiens 147-151 2160341-5 1990 There was a significant blunting of the mean peak level of ACTH and the mean peak change of ACTH from basal as well as the area under the ACTH-time curve when clonidine was given prior to naloxone. Clonidine 159-168 proopiomelanocortin Homo sapiens 59-63 2160341-5 1990 There was a significant blunting of the mean peak level of ACTH and the mean peak change of ACTH from basal as well as the area under the ACTH-time curve when clonidine was given prior to naloxone. Clonidine 159-168 proopiomelanocortin Homo sapiens 92-96 2160341-5 1990 There was a significant blunting of the mean peak level of ACTH and the mean peak change of ACTH from basal as well as the area under the ACTH-time curve when clonidine was given prior to naloxone. Clonidine 159-168 proopiomelanocortin Homo sapiens 92-96 2160341-7 1990 We conclude that clonidine, by blocking central noradrenergic pathways, which stimulate corticotropin-releasing hormone secretion, inhibits naloxone-induced ACTH secretion. Clonidine 17-26 proopiomelanocortin Homo sapiens 157-161 2554358-2 1989 In order to elucidate the relationship between noradrenergic and opioidergic functions, the plasma beta-endorphin (beta-EP) response to clonidine and the cortisol response to dexamethasone were evaluated together in 25 patients suffering from migraine without aura, and with chronic tension headache (MTH). Clonidine 136-145 proopiomelanocortin Homo sapiens 99-113 2552488-8 1989 In MM patients beta-EP and GH plasma levels were stimulated by clonidine only in the early luteal phase, whereas they remained unchanged when they were stimulated in the premenstrual period. Clonidine 63-72 proopiomelanocortin Homo sapiens 15-22 2554358-3 1989 Baseline beta-EP plasma levels and beta-EP response to clonidine were significantly lower in MTH subjects than in controls, suggesting a postsynaptic hypothalamo-pituitary impairment. Clonidine 55-64 proopiomelanocortin Homo sapiens 35-42 2554358-2 1989 In order to elucidate the relationship between noradrenergic and opioidergic functions, the plasma beta-endorphin (beta-EP) response to clonidine and the cortisol response to dexamethasone were evaluated together in 25 patients suffering from migraine without aura, and with chronic tension headache (MTH). Clonidine 136-145 proopiomelanocortin Homo sapiens 115-122 2554358-5 1989 An inverse correlation was found between pain severity and beta-EP secretion induced by clonidine (delta max), and no relationship was found between beta-EP and mood. Clonidine 88-97 proopiomelanocortin Homo sapiens 59-66 3241222-4 1988 Treatment with clonidine for 14 days normalized low beta-endorphin, high plasma noradrenaline and high blood pressure in essential hypertensives at rest, but had no effect in controls. Clonidine 15-24 proopiomelanocortin Homo sapiens 52-66 3241222-5 1988 After bicycle exercise clonidine induced a threefold greater increase in beta-endorphin in controls than in essential hypertensives. Clonidine 23-32 proopiomelanocortin Homo sapiens 73-87