PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
8627569-8	1996	It is concluded that clonidine acts on alpha-1 adrenoceptors as a partial agonist, causing relaxation of the mesenteric artery precontracted with norepinephrine or contraction of preparations precontracted with endothelin.	Clonidine	21-30	adrenoceptor alpha 1D	Homo sapiens	39-46	
14656950-3	2004	However, clonidine has a low alpha2/alpha1 selectivity ratio.	Clonidine	9-18	adrenoceptor alpha 1D	Homo sapiens	29-42	
24129834-11	2014	At high serum concentrations, the pharmacodynamic effects of clonidine appear to cause significant peripheral alpha-1 adrenergic stimulation.	Clonidine	61-70	adrenoceptor alpha 1D	Homo sapiens	110-117	
1671406-6	1991	Methoxamine hydrochloride and clonidine (alpha-1- and 2-adrenergic agonists) did not induce an increase in [Ca++]i.	Clonidine	30-39	adrenoceptor alpha 1D	Homo sapiens	41-48	
7981483-7	1994	Elderly monkeys show deficits in performance of the delayed response task, which can be reversed directly by both the mixed alpha 1/alpha 2-agonist clonidine, the more specific alpha 2-agonist guanfacine and also, indirectly, by the alpha 2-antagonist yohimbine.	Clonidine	148-157	adrenoceptor alpha 1D	Homo sapiens	124-139	
8833417-1	1996	Abstract The mixed alpha(1)/alpha(2) adrenoceptor agonist clonidine has been shown by us previously to impair certain attentional and executive functions in healthy volunteers.	Clonidine	58-67	adrenoceptor alpha 1D	Homo sapiens	19-27	
8096770-2	1993	Clonidine, an alpha 2-adrenergic drug with a selectivity ratio of 200/1 for alpha 2/alpha 1 has been used in clinical practice for more than 20 years.	Clonidine	0-9	adrenoceptor alpha 1D	Homo sapiens	76-91	
2540318-4	1989	On application of norepinephrine, phenylephrine (alpha-1 adrenergic agonist) or clonidine (alpha-2 adrenergic agonist) the arteries contracted in a dose-dependent manner and, in terms of the mean EC50 values, the order of potencies was clonidine greater than norepinephrine greater than phenylephrine.	Clonidine	236-245	adrenoceptor alpha 1D	Homo sapiens	49-56	
2171846-1	1990	The alpha 1- and alpha 2-adrenergic venoconstriction in dorsal hand veins of normal subjects was determined by infusion of phenylephrine or clonidine.	Clonidine	140-149	adrenoceptor alpha 1D	Homo sapiens	4-24	
6301291-9	1983	These data indicate that phenylephrine and clonidine act by different mechanisms and, taken together with previous studies, suggest that alpha 1- and alpha 2-stimulation utilize different excitation-contraction coupling mechanisms.	Clonidine	43-52	adrenoceptor alpha 1D	Homo sapiens	137-157