PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
21324347-2	2011	In order to evaluate whether the inhibitory action of clonidine (an alpha2-adrenergic/imidazoline receptor agonist) on induced sodium intake is mediated by the beta-endorphinergic system, we used a beta-endorphin deficient mouse line.	Clonidine	54-63	pro-opiomelanocortin-alpha	Mus musculus	160-174	
21324347-5	2011	The results indicate that clonidine administration during the first stage of the test exerts an equivalent inhibition on sodium intake regardless of the genotype; however, in the final stage of the test, a reversal of the inhibitory response on induced sodium appetite becomes evident in the mice lacking beta-endorphin.	Clonidine	26-35	pro-opiomelanocortin-alpha	Mus musculus	305-319	
7684446-5	1993	The N-acetyl derivative of beta-endorphin-(1-31) (1 pmol) increased the antinociceptive response of DAMGO, D-Ala2-D-Leu5-enkephalin and clonidine, but not of morphine, in SP-pretreated mice.	Clonidine	136-145	pro-opiomelanocortin-alpha	Mus musculus	27-41	
1447947-8	1992	It is concluded that opioids and clonidine promote analgesia after binding to receptors functionally coupled to Gi/G(o) proteins, moreover, the activity of morphine, beta-endorphin and clonidine in this test seems to be counteracted by a process involving activation of Gs alpha transducer proteins.	Clonidine	33-42	pro-opiomelanocortin-alpha	Mus musculus	166-180