PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 7401402-5 1980 In conclusion, clonidine selectively lowers DBH activity in the LC, while alpha-methyldopa appears to decrease the enzyme activity in the medullary NTS and A1 cell areas, suggesting different sites of action of both drugs. Clonidine 15-24 dopamine beta-hydroxylase Rattus norvegicus 44-47 7401402-1 1980 Repeated administrations of clonidine to spontaneously hypertensive rats (SHR) markedly lowered dopamine beta-hydroxylase (DBH) activity in the locus coeruleus (LC) and increased it in the spinal intermediolateral cell column (IML), while alpha-methyldopa tended to lower the enzyme activity in the medullary nucleus tractus solitarii (NTS) and A1 cell areas. Clonidine 28-37 dopamine beta-hydroxylase Rattus norvegicus 96-121 7401402-1 1980 Repeated administrations of clonidine to spontaneously hypertensive rats (SHR) markedly lowered dopamine beta-hydroxylase (DBH) activity in the locus coeruleus (LC) and increased it in the spinal intermediolateral cell column (IML), while alpha-methyldopa tended to lower the enzyme activity in the medullary nucleus tractus solitarii (NTS) and A1 cell areas. Clonidine 28-37 dopamine beta-hydroxylase Rattus norvegicus 123-126