PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 15271731-2 2004 We investigated the hypothesis that epidural clonidine premedication and postoperative patient-controlled epidural analgesia (PCEA) including clonidine would decrease the release of proinflammatory (interleukin (IL)-6, IL-1beta, IL-8, and tumor necrosis factor (TNF)-alpha) and antiinflammatory (IL-1 receptor antagonist (RA)) cytokines in patients who underwent elective colorectal surgery and that they would provide better postoperative analgesia. Clonidine 45-54 interleukin 1 receptor antagonist Homo sapiens 296-320 15271731-2 2004 We investigated the hypothesis that epidural clonidine premedication and postoperative patient-controlled epidural analgesia (PCEA) including clonidine would decrease the release of proinflammatory (interleukin (IL)-6, IL-1beta, IL-8, and tumor necrosis factor (TNF)-alpha) and antiinflammatory (IL-1 receptor antagonist (RA)) cytokines in patients who underwent elective colorectal surgery and that they would provide better postoperative analgesia. Clonidine 142-151 interleukin 1 receptor antagonist Homo sapiens 296-320 15271731-6 2004 For patients in the clonidine group, production of IL-1RA, IL-6, and IL-8 was significantly less increased at the end of the surgical procedure and at 12 and 24 h after surgery. Clonidine 20-29 interleukin 1 receptor antagonist Homo sapiens 51-57