PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
8029274-3	1994	Potentiation of clonidine"s effect on growth hormone levels following short-term lithium treatment appears most likely due to increased serotonergic function as a consequence of enhanced 5-HT concentrations at postsynaptic 5-HT1C receptor sites.	Clonidine	16-25	5-hydroxytryptamine receptor 2C	Rattus norvegicus	223-229	
1356149-4	1992	In contrast, pretreatment with the non-selective 5-HT1/2 antagonist, metergoline, and the 5-HT1C/5-HT2-selective antagonist, mesulergine, reduced clonidine-induced increases in growth hormone levels 81 to 87% without affecting clonidine-induced decreases in locomotor activity.	Clonidine	146-155	5-hydroxytryptamine receptor 2C	Rattus norvegicus	90-96	
1356149-4	1992	In contrast, pretreatment with the non-selective 5-HT1/2 antagonist, metergoline, and the 5-HT1C/5-HT2-selective antagonist, mesulergine, reduced clonidine-induced increases in growth hormone levels 81 to 87% without affecting clonidine-induced decreases in locomotor activity.	Clonidine	227-236	5-hydroxytryptamine receptor 2C	Rattus norvegicus	90-96	
1356149-5	1992	Two other 5-HT1C/5-HT2 antagonists, ritanserin and mianserin, also attenuated (47%) clonidine-induced increases in growth hormone levels.	Clonidine	84-93	5-hydroxytryptamine receptor 2C	Rattus norvegicus	10-16	
1356149-9	1992	These findings suggest that clonidine stimulates growth hormone secretion by activation of alpha 2 adrenergic heteroreceptors present on 5-HT nerve terminals which, in turn, enhance 5-HT activity via stimulation of postsynaptic 5-HT1C receptors to promote growth hormone releasing factor.	Clonidine	28-37	5-hydroxytryptamine receptor 2C	Rattus norvegicus	228-234	
8145893-5	1994	These findings suggest that development of functional subsensitivity of either alpha 2-adrenergic heteroreceptors or 5-HT1C receptors mediating clonidine-induced growth hormone secretion following chronic treatment with glucocorticoids and 5-HT uptake inhibitors.	Clonidine	144-153	5-hydroxytryptamine receptor 2C	Rattus norvegicus	117-123