PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 11350495-13 2000 These findings imply that angiotensin II receptor antagonists could lead to renal failure if used as antihypertensive agents in renovascular hypertension whereas this would be avoided with the use of clonidine-like analogues. Clonidine 200-209 angiotensinogen Rattus norvegicus 26-40 12185387-4 2002 Clonidine (20 nmol/ micro l) injected into the MSA reduced the ANGII-induced water intake (2.9 +/- 0.5 ml/120 min). Clonidine 0-9 angiotensinogen Rattus norvegicus 63-68 12185387-6 2002 Yohimbine + prazosin + clonidine injected into the MSA abolished the ANGII-induced water intake (0.2 +/- 0.1 and 0.2 +/- 0.1 ml/120 min, respectively). Clonidine 23-32 angiotensinogen Rattus norvegicus 69-74 12185387-9 2002 Clonidine injected into the MSA abolished the inhibitory effect of ANGII on urinary sodium. Clonidine 0-9 angiotensinogen Rattus norvegicus 67-72 12185387-11 2002 Yohimbine + clonidine attenuated the inhibitory effects of ANGII. Clonidine 12-21 angiotensinogen Rattus norvegicus 59-64 12185387-13 2002 Prazosin + clonidine attenuated the inhibitory effects of ANGII. Clonidine 11-20 angiotensinogen Rattus norvegicus 58-63 10974488-6 2000 The injection of ANGII into the LV increased the water intake, which was reduced by previous injection of clonidine (an alpha-2-adrenergic agonist) into the LH. Clonidine 106-115 angiotensinogen Rattus norvegicus 17-22 10974488-9 2000 Previous treatment with clonidine attenuated the action of ANGII in reducing the sodium, potassium and urinary volume, whereas previous treatment with yohimbine attenuated the effects of ANGII but with less intensity than that caused by clonidine. Clonidine 24-33 angiotensinogen Rattus norvegicus 59-64 10974488-11 2000 The injection of yohimbine and prazosin, which was done before the injection of clonidine, attenuated the effect of clonidine on the ANGII mechanism. Clonidine 80-89 angiotensinogen Rattus norvegicus 133-138 10974488-11 2000 The injection of yohimbine and prazosin, which was done before the injection of clonidine, attenuated the effect of clonidine on the ANGII mechanism. Clonidine 116-125 angiotensinogen Rattus norvegicus 133-138 10974488-12 2000 The results of this study led us to postulate that when alpha-2-adrenergic receptors are blocked, the clonidine may act on the imidazoline receptors to produce its effects on the ANGII mechanism. Clonidine 102-111 angiotensinogen Rattus norvegicus 179-184 9638593-3 1998 Based on the results we may conclude that clonidine associated with rilmenidine was able to block the hypertensive response to ANG II. Clonidine 42-51 angiotensinogen Rattus norvegicus 127-133 9638593-9 1998 The injection of yohimbine (80 nmol/microL) prior to clonidine blocked the effect of clonidine on the effect of ANG II (27 +/- 2 mmHg). Clonidine 85-94 angiotensinogen Rattus norvegicus 112-118 9334989-6 1997 In sham rats phenylephrine (80 nmol) into MnPO increased, whereas norepinephrine (80 nmol) and clonidine (40 nmol) reduced ANG II-induced water intake while sodium intake was reduced only by clonidine into MnPO. Clonidine 95-104 angiotensinogen Rattus norvegicus 123-129 9210098-8 1997 Previous injection of phenylephrine or norepinephrine into the MnPO of MH-lesioned rats induced a negative MAP, whereas pretreatment with clonidine or isoproterenol increased the MAP produced by ANG II injected into the MnPO of sham- or MH-lesioned rats. Clonidine 138-147 angiotensinogen Rattus norvegicus 195-201 2171000-3 1990 Previous ICV treatment with clonidine (20, 40, 80 and 120 nmol) abolished the pressor, tachycardic and dipsogenic effects of ICV AII. Clonidine 28-37 angiotensinogen Rattus norvegicus 129-132 7573486-4 1995 The increase in [Na+]i induced by 10(-9) M ANG II was attenuated by inhibiting the Na+/H+ antiporter with clonidine, whereas HOE-694, a specific blocker of the NHE-1 isoform of the Na+/H+ exchanger, had no effect. Clonidine 106-115 angiotensinogen Rattus norvegicus 43-49 7478230-3 1995 Clonidine (alpha 2 agonist) and yohimbine (alpha 2 antagonist) injected into LH previous to injection of ANGII into LV also abolished the inhibitory effect of ANGII. Clonidine 0-9 angiotensinogen Rattus norvegicus 105-110 7478230-3 1995 Clonidine (alpha 2 agonist) and yohimbine (alpha 2 antagonist) injected into LH previous to injection of ANGII into LV also abolished the inhibitory effect of ANGII. Clonidine 0-9 angiotensinogen Rattus norvegicus 159-164 7813592-6 1994 Cardiovascular analysis demonstrated that a threshold dose of angiotensin II (0.05 pmol) counteracted the vasodepressor effect produced by an ED50 dose of l-adrenaline, l-noradrenaline or clonidine coinjected in the nucleus tractus solitarii. Clonidine 188-197 angiotensinogen Rattus norvegicus 62-76 8206615-0 1994 Clonidine reverses the slowly developing hypertension produced by low doses of angiotensin II. Clonidine 0-9 angiotensinogen Rattus norvegicus 79-93 8206615-11 1994 The antihypertensive response to clonidine after 6 hours on days 2, 7, and 12 of the Ang II infusion in these rats was -18 +/- 8, -16 +/- 5, and -23 +/- 9 mm Hg, respectively. Clonidine 33-42 angiotensinogen Rattus norvegicus 85-91 2171000-6 1990 The results show that the periventricular alpha 1-adrenoceptors are involved only in the cardiovascular responses produced by central AII, whereas clonidine acting through alpha 2-adrenergic and/or imidazole receptors can modulate all actions of AII. Clonidine 147-156 angiotensinogen Rattus norvegicus 246-249 6326953-1 1984 Administration of either isoproterenol (25 micrograms/kg, s.c.) or angiotensin II (200 micrograms/kg, s.c.) induces drinking in rats within 0.5-1 h. This drinking was inhibited by prior administration of the presynaptic alpha-adrenergic agonist clonidine (12 micrograms/kg, i.p.). Clonidine 245-254 angiotensinogen Rattus norvegicus 67-81 4070024-7 1985 Since both the presynaptic alpha adrenoceptor agonist, clonidine, and the opioid antagonist, naloxone, modulate the pressor and dipsogenic responses to AII, their effects on AII-induced hypothermia were tested. Clonidine 55-64 angiotensinogen Rattus norvegicus 152-155 4070024-7 1985 Since both the presynaptic alpha adrenoceptor agonist, clonidine, and the opioid antagonist, naloxone, modulate the pressor and dipsogenic responses to AII, their effects on AII-induced hypothermia were tested. Clonidine 55-64 angiotensinogen Rattus norvegicus 174-177 6326953-2 1984 Urine output was enhanced by clonidine in the angiotensin II-, but not the isoproterenol-treated group. Clonidine 29-38 angiotensinogen Rattus norvegicus 46-60 6326953-5 1984 This dose of clonidine also enhanced the urine output after angiotensin II. Clonidine 13-22 angiotensinogen Rattus norvegicus 60-74 6326953-7 1984 administration of angiotensin II, at 4 but not 20 ng/kg was inhibited by peripheral administration of clonidine (12 micrograms/kg, i.p.). Clonidine 102-111 angiotensinogen Rattus norvegicus 18-32 6329483-3 1984 Studies reported here establish a dose-inhibition relationship between the dose of clonidine administered (2 to 32 micrograms/kg) intracerebroventricularly (IVT) and inhibition of the drinking response to peripherally administered angiotensin II (200 micrograms/kg. Clonidine 83-92 angiotensinogen Rattus norvegicus 231-245 6329483-6 1984 Yohimbine (300 micrograms/kg, SC) reversed the antidipsogenic effect of centrally administered clonidine (32 micrograms/kg, IVT) on angiotensin II-induced (200 micrograms/kg, SC) water intake. Clonidine 95-104 angiotensinogen Rattus norvegicus 132-146 6486775-4 1984 The effect of simultaneous administration of naloxone and clonidine at these submaximal doses was an additive attenuation of both angiotensin II- and isoproterenol-induced water intakes. Clonidine 58-67 angiotensinogen Rattus norvegicus 130-144 7326582-0 1981 Antidipsogenic effect of clonidine on angiotensin II-, hypertonic saline-, pilocarpine- and dehydration-induced water intakes. Clonidine 25-34 angiotensinogen Rattus norvegicus 38-52 6824960-5 1983 In view of the fact that clonidine, an alpha 2-adrenoreceptor agonist, has been shown to inhibit water intake induced by both isoproterenol and angiotensin II, the results suggest that the alpha 2-adrenoreceptor may play a role in modulating water intake induced by these two dipsogenic agents. Clonidine 25-34 angiotensinogen Rattus norvegicus 144-158 1192571-8 1975 The data presented in this paper are consistent with the conclusion that clonidine acts at some site in the sympathetic nervous system of sodium-depleted rats to inhibit renal nerve activity with a resultant suppression of renin secretion and a reduction of the angiotensin II-maintained arterial blood pressure. Clonidine 73-82 angiotensinogen Rattus norvegicus 262-276 4330157-0 1971 [The action of ST 155 (2,2,6-dichlorophenylamino-2-imidazoline hydrochloride) on the hypertensive crisis induced in the rat by administration of angiotensin II]. Clonidine 23-76 angiotensinogen Rattus norvegicus 145-159